Research InterestsMy current research focuses on: 1) Human herpesvirus 8 (HHV-8) and its role in human diseases, especially Kaposi sarcoma (KS) and diffuse body cavity lymphoma (BCL). KS and BCL are common in HIV-1 infected people, especially gay men. KS is also seen in an endemic form in Africa, sporadically among elderly men of Mediterranean extraction, and among transplant patients. HHV-8 is highly prevalent in all four settings, but its role in pathogenesis and its prevalence in the normal population are not clear. A major objective of my laboratory is to characterize the activities of viral regulatory genes and determine whether they play a role in the pathogenesis of KS. 2) Chemokines and HIV-1. Chemokines are small cytokine-like proteins. Some of their receptors serve as coreceptors for HIV-1 infection, and HIV-1 is inhibited by naturally expressed chemokines. We are studying how expression of chemokine genes is regulated to understand how host defenses can deal with HIV-1 more effectively.
Karasev, A.V., Foulke, S., Wellens,C., Rich, A., Shon, K.J., Zwierzynski, I., Hone, D., Koprowski, H., and Reitz,M. (2005). Plant based HIV-1 vaccine candidate: Tat protein produced in spinach. Vaccine 23, 1875-1880.
Guo,H.G., Pati,S., Sadowska,M., Charurat,M., and Reitz,M. (2004). Tumorigenesis by human herpesvirus 8 vGPCR is accelerated by human immunodeficiency virus type 1 Tat. J. Virol. 78, 9336-9342.
Reid,W., Abdelwahab,S., Sadowska,M., Huso,D., Neal,A., Ahearn,A., Bryant,J., Gallo,R.C., Lewis,G.K., and Reitz,M. (2004). HIV-1 transgenic rats develop T cell abnormalities. Virology 321, 111-119.
Guo,H.-G., Sadowska,M., Reid,W., Tschachler,E., Hayward,G.S., and Reitz,M.S. (2003). Kaposi's sarcoma-like tumors in a human herpesvirus 8 ORF74 transgenic mouse. J Virol 77, 2631-2639.
Pal,R., Taylor,B.A., Foulke,J.S., Woodward,R., Merges,M., Praschunis,R., Gibson,A., and Reitz,M. (2003). Characterization of a simian-human immunodeficiency virus encoding the envelope gene from the CCR5-tropic HIV-1 Ba-L. JAIDS 33, 300-307.
Pati,S., Foulke,J.S., Jr., Barabitskaya,O., Kim,J., Nair,B.C., Hone,D., Smart,J., Feldman,R.A., and Reitz,M. (2003). Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat. J Virol 77, 5759-5773.
Smith,S.M., Pentlicky,S., Klase,Z., Singh,M., Neuveut,C., Lu,C.Y., Reitz,M.S., Jr., Yarchoan,R., Marx,P.A., and Jeang,K.T. (2003). An in vivo replication-important function in the second coding exon of Tat is constrained against mutation despite cytotoxic T lymphocyte selection. J. Biol. Chem. 278, 44816-44825.
Agwale,S.M., Shata,M.T., Reitz,M.S., Jr., Kalyanaraman,V.S., Gallo,R.C., Popovic,M., and Hone,D.M. (2002). A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice. Proc. Natl. Acad. Sci. U. S. A. 99, 10037-10041.
S.M.Agwale, C.Zeh, K.E.Robbins, L.Odama, A.Saekhou, A.Edubio, M.Njoku, N.Sani-Gwarzo, M.S.Gboun, F.Gao, M.Reitz, D.Hone, D.Pieniazek, C.Wambebe, and M.L.Kalish, Molecular surveillance of HIV-1 field strains in Nigeria in preparation for vaccine trials(1), Vaccine 20:2131 (2002).
S.Pati, C.B.Pelser, J.Dufraine, J.L.Bryant, M.S.Reitz, Jr., and F.F.Weichold, Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma, Blood 99:3771 (2002).
S.M.Agwale, K.E.Robbins, L.Odama, A.Saekhou, C.Zeh, A.Edubio, O.M.Njoku, N.Sani-Gwarzo, M.F.Gboun, F.Gao, M.Reitz, D.Hone, T.M.Folks, D.Pieniazek, C.Wambebe, and M.L.Kalish, Development of an env gp41-Based Heteroduplex Mobility Assay for Rapid Human Immunodeficiency Virus Type 1 Subtyping, J Clin Microbiol 39:2110 (2001).
J.Bodor, L.Feigenbaum, J.Bodorova, C.Bare, M.S.Reitz, Jr., and R.E.Gress, Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER), J Leukoc.Biol 69:1053 (2001).
E.D.Miller, K.M.Duus, M.Townsend, Y.Yi, R.Collman, M.Reitz, and L.Su, Human immunodeficiency virus type 1 IIIB selected for replication in vivo exhibits increased envelope glycoproteins in virions without alteration in coreceptor usage: separation of in vivo replication from macrophage tropism, J. Virol. 75:8498 (2001).
S.Pati, M.Cavrois, H.G.Guo, J.S.Foulke, Jr., J.Kim, R.A.Feldman, and M.Reitz, Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis, J.Virol. 75:8660 (2001).
W.Reid, M.Sadowska, F.Denaro, S.Rao, J.Foulke, Jr., N.Hayes, O.Jones, D.Doodnauth, H.Davis, A.Sill, P.O'Driscoll, D.Huso, T.Fouts, G.Lewis, M.Hill, R.Kamin-Lewis, C.Wei, P.Ray, R.C.Gallo, M.Reitz, and J.Bryant, An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction, Proc Natl Acad Sci U.S.A 98:9271 (2001).
M.T.Shata, M.S.Reitz, Jr., A.L.DeVico, G.K.Lewis, and D.M.Hone, Mucosal and systemic HIV-1 Env-specific CD8(+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector, Vaccine 20:623 (2001).
T.R.Fouts, R.Tuskan, K.Godfrey, M.Reitz, D.Hone, G.K.Lewis, and A.L.DeVico, Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex [In Process Citation], J.Virol. 74:11427 (2000).
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