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Henry H Holcomb
 

Henry H Holcomb M.D.

Academic Title: Adjunct Professor
Primary Appointment: Psychiatry
hholcomb@mprc.umaryland.edu
Location: MPRC, 55 Wade Avenue, Catonsville MD 21228
Phone: (410) 402-6817
Phone: (301) 785-4799
Fax: (410) 402-6077

Personal History:

EDUCATION/TRAINING

Rice University, Houston, TX, B.A. Biology, 1972

University of Texas School of Medicine, San Antonio, TX, M.D. 1977

Positions and Employment

1977-1978 Internship, University of Chicago Hospitals and Clinics, Internal Medicine

1978-1979 Research Fellowship, Illinois State Psychiatric Institute and University of Chicago Department of Psychiatry, with Dr. H. Y. Meltzer

1979-1981 Residency, Yale University School of Medicine, Department of Psychiatry, New Haven, Connecticut

1982-1985 Clinical Associate, Clinical Brain Imaging Section, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland

1985-2000 Assistant Professor, The Johns Hopkins University, School of Medicine, Department of Radiology, Division of Nuclear Medicine 2000-Present Adjunct Assistant Professor, Johns Hopkins University, Department of Psychiatry

1985-1995 Assistant Research Professor, Maryland Psychiatric Research Center, Baltimore, Maryland

1996-2009: Associate Professor, Maryland Psychiatric Research Center, Baltimore, Maryland

2009 - present: Professor, Maryland Psychiatric Research Center, Baltimore, Maryland

Honors

1967 National Merit Commendation

1971-1972 President of Lovett College, Rice University

1972 Watson Fellowship Nomination, Rice University Philosophy Department

Research Interests:

Neural plasticity associated with perceptual learning, motor learning, transcranial magnetic stimulation, and physical trauma.

Clinical Speciality:

Psychiatry and psychopharmacology

Lab Techniques and Equipment:

1) Positron Emission Tomography (PET) applied to cerebral blood flow;

2) Magnetic Resonance Imaging (MRI) applied to cognition and perception;

3) Transcranial Magnetic Stimulation (TMS) applied to MRI navigational targeting


Publications:

Holcomb HH, Links J, Smith C, Wong D: Positron emission tomography: Measuring the metabolic and neurochemical properties of the living human nervous system. In: Brain Imaging: Applications in Psychiatry, N. Andreasen, ed., American Psychiatric Press, Inc., Washington, D.C., pp: 235-370, 1989.
 
Loats HL, Holcomb HH: Image Analysis. In: Innovations in Diagnostic Radiology, J.H. Anderson, ed., Springer - Verlag, New York, pp 23-45, 1989. 
 
Holcomb HH, Cascella NG, Medoff DR, Gastineau EA, Loats HL, Thaker GK, Conley RR, Dannals RF, Wagner HN, Tamminga CA. PET-FDG Test-Retest Reliability During a Visual Discrimination Task Schizophrenia.  J Computer Assisted Tomography 17(5):704-709, 1993. 
 
Holcomb HH, Ritzl EK, Medoff DR, Nevitt J, Gordon B, Tamminga CA. Tone discrimination performance in schizophrenic patients and normal volunteers: the impact of stimulus presentation levels and frequency differences. Psychiatry Research 57:75-82, 1995.
 
Lahti AC, Holcomb HH, Medoff DR, Tamminga CA. Ketamine activates psychosis and alters limbic blood flow in schizophrenia. NeuroReport 6:869-872, 1995.
 
Holcomb HH. Mental Illness, Patterns of Neuronal Activity. In: Principles of Nuclear medicine, Second Edition, Henry N. Wagner and Zsolt Szabo (Eds.), W.B. Saunders Company, Orlando, Florida, 1995.
 
Holcomb HH, Caudill PJ, Zhao Z, Medoff D, Ravert HT, Dannals RF, Tamminga CA. rCBF in cingulate, frontal and parietal cortices is highly correlated with accurate decision response time during tone recognition. Soc. Neurosci. Abstr., vol. 21, part 3, p. 1988, 1995.
 
Holcomb HH, Cascella NG, Thaker GK, Medoff DR, Dannals RF, Tamminga CA. Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol. Am.J Psychiat. 153:41-49, 1996.
 
Holcomb HH, Gordon B, Loats HL, Gastineau E, Zhao Z, Medoff D, Dannals RF, Woods R, Tamminga CA. Brain metabolism patterns are sensitive to attentional effort associated with a tone recognition task. Biol. Psychiatry 39:1013-1022, 1996.
 
Shadmehr R, Holcomb HH. Neural Correlates of Motor Memory Consolidation. Science. 277: 821-825, 1997.
 
Shadmehr R, Holcomb HH. Role of the ventral prefrontal cortex in the inhibitory control of motor memories: A positron emission tomography study. Experimental Brain Research 26:235-251, 1999.
 
Holcomb HH, Medoff DR, Caudill PJ, Zhao Z, Lahti AC, Dannals RF, and Tamminga CA. Cerebral blood flow relationships associated with a difficult tone recognition task in trained normal volunteers. Cerebral Cortex. 8: 534-542, 1998.
 
Holcomb HH, Lahti AC, Medoff DR, Weiler M, Dannals RF, Tamminga CA. Brain activation patterns in schizophrenic and comparison volunteers during a matched-performance auditory recognition task. American Journal of Psychiatry, 157(10):1634-45, 2000.
 
Holcomb HH, Lahti AC, Medoff DR, Weiler M, Tamminga CA. Sequential regional cerebral blood flow brain scans using PET with H215O demonstrate ketamine actions in CNS dynamically. Neuropsychopharmacology, 25:165-172, 2001.
 
Nezafat R, Shadmehr R, Holcomb HH. Long-term adaptation to dynamics of reaching movements: A PET study. Experimental Brain Research, 140:66-76, 2001.
 
Lahti AC, Holcomb HH, Medoff DR, Weiler MA, Tamminga CA, Carpenter WT. Altered regional blood flow patterns in schizophrenia with primary negative symptoms during an effortful auditory recognition task. American Journal of Psychiatry, 158:1797-1808, 2001.
 
Medoff DR, Holcomb HH, Lahti AC, Tamminga CA. Probing the Human Hippocampus Using rCBF: Contrasts in Schizophrenia. Hippocampus 14:543-550, 2001.
 
Holcomb HH, Medoff DR, Lahti AC, Tamminga CA. Perceptual skill and brain physiology in subgroups of persons with schizophrenia. Dialogues in Clinical Neurosciences, 3:294-295, 2001.
 
Lahti AC, Holcomb HH, Weiler MA, Medoff DR, Tamminga CA. Functional effects of antipsychotic drugs: comparing clozapine with haloperidol. Biological Psychiatry, 53:601-608, 2003
 
Holcomb HH, Parwani A, McMahon R, Lahti AC, Medoff DR, Tamminga CA. Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminations. Psychiatry Research, 127 (3):207-216, 2004.
 
Holcomb HH. Practice, Learning, and the Likelihood of Making an Error: How Task Experience Shapes Physiological Response in Patients with Schizophrenia. Psychopharmacology, 174:136-142, 2004.
 
Holcomb HH, Rowland LM, Tagamets MA. Cognitive Dysfunction in Schizophrenia: Glutamatergic Hypoactivity and Dopaminergic Failure. Drug Discovery Today: Disease Mechanisms, www.drugdiscoverytoday.com   vol 1, issue 4: 435-439, 2005.
 
Holcomb HH, Lahti AC, Medoff DR, Cullen T, Tamminga CA. Effects of non-competitive NMDA receptor blockade on anterior cingulate cerebral blood flow in volunteers with schizophrenia. Neuropsychopharmacology. Neuropsychopharmacology, 30:2275-2282, 2005.
 
Lahti AC, Holcomb HH, Weiler MA, Medoff Dr, Frey KN, Hardin M, Tamminga CA. Clozapine but not haloperidol re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology, 29 (1): 171-8, 2004.
 
Lahti AC, Weiler MA, Medoff DR, Tamminga CA, Holcomb HH. Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia. Psychiatry Research, Neuroimaging, 139:19-30.
 
Tamminga CA, Holcomb HH. Phenotype of schizophrenia, a review and formulation. Mol Psychiatry, 10 (1):27-39, 2005.
 
Hong LE, Tagamets M, Avila M, Wonodi I, Holcomb H, Thaker G. Specific motion processing pathway deficit during eye tracking in schizophrenia: a performance-matched functional magnetic resonance imaging study. Biological Psychiatry, 57:726-732, 2005.
 
Shepard PD, Holcomb HH, Gold J. Having and not having, the role of the habenula in error signal generation. Schizophrenia Bulletin, 32(3): 417-421, 2006.
 
Holcomb HH, Rowland LM. How Schizophrenia and Depression Disrupt Reward Circuitry. Current Treatment Options In Neurology, 9:357-362 2007.

 
Rowland LM, Shadmehr R, Kravitz D, Holcomb HH. Sequential neural changes during motor learning in schizophrenia. Psychiatry Research, Neuroimaging, 163:1-12, 2008.

Holcomb HH, Rowland LM, Tagamets MA. Cognitive dysfunction in schizophrenia: glutamatergic hypoactivity and dopaminergic failure. Drug Discovery Today: Disease Mechanisms 1(4): 435-439, 2004.

Tamminga CA, Holcomb HH. Phenotype of schizophrenia: a review and formulation. Mol Psychiatry 10 (1): 27-39, 2005.

Holcomb HH, Lahti AC, Medoff DR, Cullen T, Tamminga CA. Effects of non competitive NMDA receptor blockade on anterior cingulate cerebral blood flow in volunteers with schizophrenia. Neuropsychopharmacology 30 (12): 2275-2282, 2005.

Lahti AC, Weiler MA, Holcomb HH, Tamminga CA, Carpenter WT, McMahon R. Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia. Neuropsychopharmacology 31(1): 221-230, 2006.

Shepard PD, Holcomb HH, Gold JM. The presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes. Schizophrenia Bulletin, 32 (3): 417-421, 2006.

Holcomb HH, Rowland LM. How Schizophrenia and Depression Disrupt Reward Circuitry. Current Treatment Options In Neurology, 9:357-362 2007.

Rowland LM, Shadmehr R, Kravitz D, Holcomb HH. Sequential neural changes during motor learning in schizophrenia. Psychiatry Research: Neuroimaging, 163: 1-12, 2008.

Rowland LM, Spieker EA, Holcomb HH. A review of diffusion tensor imaging in schizophrenia, Clinical Schizophrenia & Related Psychoses, 2009.

Lahti AC, Weiler MA, Holcomb HH, Tamminga CA, Cropsey KL. Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia. Neuropsychopharmacology, 34(13):2675-90, 2009. PMID: 19675535

Rowland LM, Beason-Held L, Tamminga CA, Holcomb HH. The interactive effects of ketamine and nicotine on human cerebral blood flow. Psychopharmacology, 208 (4): 575-584, 2010. PMID: 20066400

Holcomb HH, Murray GK. Successful learning in schizophrenia, functional neuroimaging studies and theoretical considerations. Schizophrenia Bulletin 36 (3):463-4, 2010. PMID: 20403923

Rowland LM, Griego JA, Spieker EA, Cortes CR, Holcomb HH. Neural changes associated with relational learning in schizophrenia. Schizophrenia Bulletin 36 (3):496-503, 2010. PMID: 20418447