Academic Title:
Professor
Primary Appointment:
Neurobiology
Administrative Title:
Chair of the Department of Neurobiology
Location:
HSF-I, 280G
Phone (Primary):
(410) 706-8912
Education and Training
- 1985: Ben Gurion University, Israel - B. Med. Sci., Medical Sciences
- 1988: Ben Gurion University, Israel - Ph.D., Neurobiology
- 1988-1991: The Rockefeller University, New York - Postdoc, Neurophysiology
Biosketch
Dr. Keller has been studying sensory processing for over 30 years, starting with his predoctoral work in neuroanatomy with Edward L. White, continuing with his postdoctoral training in neurophysiology with Hiroshi Asanuma at The Rockefeller, and in his own laboratory.
For the past decade his work has been focused on brain circuits involved in addiction, chronic pain and affective disorders. He is particularly interested in the role of descending pain modulatory pathways, and in reward pathways—involving thalamus, prefrontal cortex, parabrachial nucleus, periaqueductal gray and related structures—in the affective components of pain, and in drug addiction.
Work in Dr. Keller's lab, The Laboratory of Sensory Perception, takes advantage of multidisciplinary approaches, including in vitro and in vivo electrophysiology, optogenetics, calcium and voltage-sensitive dye imaging, extracellular recordings of units, field potential and EEG from awake and anesthetized preparations, neuroanatomical tract tracing and immunocytochemical techniques, and related analytical approaches.
Dr. Keller has a demonstrated record of productive collaboration with mathematicians, physicists, and computational neuroscientists to study neuronal networks.
Research/Clinical Keywords
sensory perception, chronic pain, descending pain modulation, drug abuse
Highlighted Publications
Alipio, JB, Haga, C, Fox, ME, Arakawa, K, Balaji, R, Cramer, N, Lobo, MK, Keller, A (2021) Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior. J Neurosci, doi: 10.1523 / JNEUROSCI.2470-20.2020
Uddin, O, Anderson, M, Smith, J, Masri, R, Keller, A (2021) Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection. Neurobiology of Pain, 9:100060.
Uddin, O, Jenne, C, Fox, ME, Arakawa, K, Keller, A, Cramer, N (2021) Divergent profiles of fentanyl withdrawal and associated pain in mice and rats. Pharmacol Biochem Behav, 200:173077.
Cramer, N, Silva-Cardoso, G, Masri, R, Keller, A (2021) Control of synaptic transmission and neuronal excitability in the parabrachial nucleus. Neurobiology of Pain, 9:100057.
Alipio, JB, Brockett, AT, Fox, ME, Tennyson, SS, deBettencourt, CA, El-Metwally, D, Francis, NA, Kanold, PO, Lobo, MK, Roesch, MR, Keller, A (2020) Enduring consequences of perinatal fentanyl exposure in mice. Addict Biol, e12895.
Raver, C, Uddin, O, Ji, Y, Li, Y, Cramer, N, Jenne, C, Morales, M, Masri, R, Keller, A (2020) An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain. J Neurosci, 40:3424-3442. PMC7178908
Lab Techniques and Equipment
Work in Dr. Keller's laboratory takes advantage of multidisciplinary approaches, including:
- in vitro and in vivo electrophysiology
- optogenetics, calcium and voltage-sensitive dye imaging
- extracellular recordings of units
- field potential and EEG from awake and anesthetized preparations
- neuroanatomical tract tracing and immunocytochemical techniques
- related analytical approaches
Dr. Keller has a demonstrated record of productive collaboration with mathematicians, physicists, and computational neuroscientists to study neuronal networks.