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Elena N Klyushnenkova Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Surgery
eklyushnenkova@smail.umaryland.edu
Location: MSTF 400A
Phone: (410) 706-0755
Fax: (410) 706-0311
Lab: (410) 706-1810

Personal History:

Positions and Employment

1985 - 1988: Junior Scientist, Laboratory of Cellular Immunology, Institute of Biotechnology, Moscow, Russia

1988 - 1993: Scientist, Laboratory of Immunochemistry and Hybridoma Technology, Institute of Molecular Diagnostics and Therapy, Moscow, Russia

1993 -1995: Research Fellow, Department of Cellular Immunology, Alton Ocshner Medical Foundation, New Orleans, LA

1995 -1997: Research Fellow, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD

1997 - 1999: Research Scientist, Department of Cellular Immunology, OSIRIS Therapeutics Inc, Baltimore, MD

1999 - 2001: Research Fellow, Division of Urology, University of Maryland School of Medicine, Baltimore, MD

2001 - 2002: Senior Research Associate, SAIC, Frederick, MD

2002 - 2005: Research Investigator, VAMHCS, Research & Development, Baltimore, MD

2003 - 2005: Adjunct Assistant Professor, UMB, School of Medicine, Department of Surgery, Baltimore, MD

2004 - present: Associate Member, Program in Oncology, Hormone Responsive Cancers, University of Maryland Greenebaum Cancer Center, Baltimore, MD

2005 - present: Assistant Professor, UMB, School of Medicine, Department of Surgery, Baltimore, MD

2005 - present: Research Investigator (without compensation, WOC), VAMHCS, Research & Development, Baltimore, MD

2006 - present: Member, Program in Oncology, Tumor Immunology and Immunotherapy, University of Maryland Greenebaum Cancer Center, Baltimore, MD

Honors and Awards

1993: International Cancer Technology Transfer (ICRETT) Fellowship Award

2001: The American Foundation for Urologic Disease and the American Urological Association Research Scholar Program Award

Research Interests:

Tumor immunology, autoimmunity, prostate cancer, cancer vaccines, regulation of immune response, immunological monitoring

Publications:

Kabanov A. V., Ovcharenko A. V., Melik-Nubarov N. S., Bannikov A. I., Lisok T. P., Klyushnenkova E. N., Cherchenko N. G., Alakhov V. Yu., Levashov A. V., Kiselev V. I. et al. 1990. Effective inhibition of viral reproduction by hydrophobized antiviral antibodies. Biomedical Science 1(1), 63-67. PMID: 2130920

Klyushnenkova E. N., and Malaytsev, V.V. 1992. [The production and characteristics of an interleukin-6-dependent hybridoma]. Biull. Eksp. Biol. Med. 8:179-181 (Russian). PMID: 1467486

Klyushnenkova E. N.,Lutskaia T. D., Golenkov, A. K., and Malaitsev, V. V. 1993. [Production of interleukin-1 and interleukin-6 in a culture of mononuclear cells of peripheral blood and bone marrow in multiple myeloma]. Biull. Eksp. Biol. Med. 5:555-558 (Russian). PMID: 8043836

Kim, H.-S., X. Zhang, E. N. Klyushnenkova, and Y. S. Choi. 1995. Stimulation of germinal center B lymphocyte proliferation by FDC-like cell line, HK. J. Immunol. 155:1101-1109. PMID: 7543513

Klyushnenkova, E. N., L. Li, R. J. Armitage, and Y. S. Choi. 1996. CD48 provides an accessory signal for CD40-mediated activation of human B cells. Cell. Immunol. 174: 90-98. PMID: 8929458

Batrakova E. V., Dorodnych T. Y., Klinskii E. Y., Klyushnenkova E. N., Shemchukova O. B., Goncharova O. N., Arjakov S. A., Alakhov V. Y., Kabanov A. V. 1996. Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity. Br. J. Cancer 74(10):1545-1552. PMID: 8932333

Golenkov A. K., Lutskaia T. D., Klyushnenkova E. N., Tishenina R. S., Valiulina L. S., Novikov V. E., Mitina T.A. 1996. [The extratumor mechanisms of osteolysis in multiple myeloma and the means for their correction]. Ter Arkh. 68(7):58-61. (Russian). PMID: 8928074

Klyushnenkova, E. N., and P. Vanguri. 1997. Ia expression and antigen presentation by glia: strain and cell type-specific differences among rat astrocytes and microglia. J. Neuroimmunol. 79:190-201. PMID: 9394792

Biragyn A., M. Surenhu, D. Yang, P. A. Ruffini, B. A. Haines, E. Klyushnenkova, J. J. Oppenheim, and L. W. Kwak. 2001. Factors of innate immunity that target immature, but not mature dendritic cells induce antitumor immunity when genetically fused with non-immunogenic tumor antigens. J. Immunol. 167:6644-6653. PMID: 11714836

Biragyn, A., P. A. Ruffini, C. A. Leifer, E. Klyushnenkova, A. Shakhov, O. Chertov, A. K. Shirakawa, J. M. Farber, D. M. Segal, J. J. Oppenheim, and L. W. Kwak. 2002. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 298:1025-1029. PMID: 12411706

Klyushnenkova, E., Ponniah, S., Rodriguez, A, Kodak, J, Mann, D. L., Langerman, A, Nishimura, M., and Alexander, R. B. 2004. CD4 and CD8 T lymphocytes recognition of prostate specific antigen in granulomatous prostatitis. J. Immunotherapy 27(2):136-146 (corresponding author). PMID: 14770085

Alexander, R. B., D. L. Mann, A.A. Borkowski, M. Fernandez-Vina, E. N. Klyushnenkova, J. Kodak, K. J. Propert, and M. Kincaid. 2004. Granulomatous prostatitis linked to HLA-DRB1*1501. J. Urology 17(6/1): 2326-2329. PMID: 15126814

Klyushnenkova, E., J. D. Mosca, V. Shustova, M. K. Majumdar, K. J. Beggs, D. W. Simonetti, R. J. Deans, and K. R. McIntosh. 2005. T Cell Responses to Allogeneic Human Mesenchymal Stem Cells: Immunogenicity, Tolerance, and Suppression. J. Biomed. Sci. 12(1): 47-57. PMID: 15864738

Klyushnenkova, E. N, J. Link, W. T. Oberle, J. Kodak, C. Rich , A. A. Vandenbark and R. B. Alexander. Identification of HLA-DRB1*1501-restricted T cell epitopes from Prostate Specific Antigen. 2005. Clin. Cancer Res. 11(8): 2853-2861 (corresponding author). PMID: 15837732

Kodak, J. A., D. L. Mann, E. N. Klyushnenkova, and R.B. Alexander. 2006. Activation of innate immunity by prostate specific antigen (PSA). Prostate 66:1592-1599. PMID: 16683268

Klyushnenkova, E. N., Kouiavskaia, D. V., Kodak, J. A., Vandenbark, A. A., and Alexander, R. B. 2007. Identification of HLA-DRB1*1501-restricted T-cell epitopes from human Prostatic Acid Phosphatase. Prostate 67:1019-1028 (corresponding author). PMID: 17455230

Klyushnenkova E. N., D. V. Kouiavskaia, C. A. Berard, and R. B. Alexander. 2009. Cutting Edge: Permissive MHC class II allele changes the pattern of anti-tumor immune response resulting in failure of tumor rejection. J. Immunology, 182(3):1242-1246 (corresponding author). PMID: 19155468 (NIHMS82060).

Kouiavskaia D.V., S. Southwood, C. A. Berard, E. N. Klyushnenkova and R. B. Alexander. 2009. T cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome. J. Urology, 182(5):2483-2489 (NIHMS102397).