Dr. Maiseyeu conducted postdoctoral research in cardiovascular nano- and biomedicine at Ohio State's Dorothy M. Davis Heart and Lung Research Institute (DHLRI) and served as an American Heart Association postdoctoral fellow at DHLRI. Before joining the University of Maryland School of Medicine faculty in 2013, Dr Maiseyeu was a Research Assistant Professor in the department of Internal Medicine at Ohio State University.
Dr. Maiseyeu and his research team are developing new nanoparticle agents that selectively accumulate in atherosclerosis allowing for cardiovascular disease imaging and therapy. In addition to imaging and drug delivery projects, our laboratory investigates lipoproteins and their function, particularly in response to various environmental and physiological stressors. Key themes of current research include:
Lab Techniques and Equipment:
Because my laboratory’s research focus is cardiovascular imaging, my team and I employ various diagnostic methods to detect cardiovascular disease and its biomarkers. We frequently use high-field magnetic resonance imaging, intravital confocal microscopy and whole-body fluorescence imaging. We conduct experiments, such as pharmacokinetic analysis and atherosclerosis biomarker identification and quantification. We also develop methods for isolation and purification via fast protein liquid chromatography (FPLC), ultracentrifugation, and flow-cytometric cell analysis. In our pharmacokinetic studies, HDL function investigations, and synthetic and natural nanoparticle work we use liquid chromatography-mass spectrometry (LCMS) in order to detect lipid biomarkers, small molecules, and peptides.
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