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Sandra  Jurado Sanchez
 

Sandra Jurado Sanchez Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Pharmacology
sjurado@som.umaryland.edu
Location: BRB, 5-040
Phone: 410-706-5816

Personal History:

My scientific interests have always revolved around the search for mechanisms underlying neuroplasticity and the bidirectional modulation of synaptic transmission. I received my PhD from the Complutense University of Madrid under the mentorship of Dr. Magdalena Torres. My PhD Thesis employed molecular and cell biology assays to elucidate how NMDA receptors (NMDARs) activity regulates protein and mRNA levels of molecules involved in retrograde signaling in cerebellar granule cells. For my postdoctoral training, I joined the laboratory of Dr. Jose A. Esteban at University of Michigan where I acquired a solid training in synaptic electrophysiology and neuronal imaging. Then, I joined Dr. Robert C. Malenka’s laboratory at Stanford University where I devised a number of projects to study molecular mechanisms that regulate AMPA receptors (AMPARs) trafficking during NMDAR-dependent long-term plasticity. This research led to the description of the role of AKAP-150 on the expression of NMDAR-dependent long-term depression (LTD) and the characterization of a postsynaptic SNARE machinery involved in AMPARs insertion during long-term potentiation (LTP).

Research Interests:

My fundamental interest lies in dissecting the molecular apparatus that underlies information processing and storage in the brain. In particular our research seeks to elucidate the molecular mechanisms underlying dendritic exocytosis and retrograde signaling. To achieve these goals, I will use a multidisciplinary approach including molecular and genetic manipulations, electrophysiological recordings and imaging techniques.

Lab Techniques and Equipment:

We primarily use electrophysiological recording techniques to examine synaptic transmission and plasticity in a variety of different in vitro preparations including acute brain slices and primary neurons in culture. Viral mediated simultaneous expression of shRNAs and cDNAs are used to study the role of neuronal proteins in synaptic plasticity. Fluorescence imaging techniques are also used to examine the intracellular trafficking of synaptic proteins and neurotransmitter exocytosis.

In addition, the Jurado lab will also focus on the development of novel optogenetic tools to regulate neuronal signaling and function.

Our lab is interested in recruiting talented scientists at all levels. Please contact sjurado@som.umaryland.edu.


Publications:

Jurado S, Goswami D, Zhang Y Südhof TC, Malenka RC. LTP requires unique postsynaptic SNARE fusion machinery. Neuron 2013 77(3):542-58.

Jurado S, Knafo S. Microscale AMPAR Reorganization and Dynamics of the Postsynaptic Density. J Neurosci. 2012 23(32): 7103-5.

Jurado S, Biou V, Malenka RC. A calcineurin/AKAP complex is required for NMDA receptor dependent-LTD. Nat. Neurosci. 2010 13(9):1053-5.

Jurado S, Benoist M, Lario A, Petrok CM, Esteban JA. PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J. 2010 29(16):2827-40.

Jurado S, Rodríguez-Pascual F, Sánchez-Prieto J, Reimunde FM, Lamas S, Torres M. NMDA induces post-transcriptional regulation of alpha2-guanylyl-cyclase-subunit expression in cerebellar granule cells. J Cell Sci. 2006 15(119):1622-31.

Jurado S, Sánchez-Prieto J, Torres M. Expression of cGMP-dependent protein kinases (I   and II) and neuronal nitric oxide synthase in the developing rat cerebellum. Brain Res. Bull. 2005. 65(2):111-15.

Jurado S, Sánchez-Prieto J, Torres M. Elements of the nitric oxide/cGMP pathway expressed in cerebellar granule cells: biochemical and functional characterization. Neurochemistry International. 2004 45(6):833-43.

Jurado S, Sánchez-Prieto J, Torres M. Differential expression of NO sensitive guanylyl cyclase subunits during the development of rat cerebellar granule cells: regulation via NMDA receptors. J Cell Sci. 2003 116:3165-75


Links of Interest:

Jurado Lab