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Ying  Zou
 

Ying Zou M.D., Ph.D.

Academic Title: Associate Professor
Primary Appointment: Pathology
Additional Title(s): Director, Clinical Cytogenetics Lab
yzou@som.umaryland.edu
Location: BRB, 8051
Phone: 410-706-1282
Fax: 410-706-6068
Lab: 410-706-4063

Personal History:

Education

  • M.D. Peking University / Peking Union Medical College, 1995
  • Ph.D. University of Texas Southwest Medical Center, 2004

Post Graduate Training

  • Fellow, Dept. Human Genetics, Medical Center of Virginia \ Virginia Commonwealth University, Richmond, VA
  • Fellow, Dept. Laboratory Medicine, Mayo Clinic, Rochester, MN
  • Fellow, Human Genetics, Boston University, Boston, MA

Research Interests:

Our laboratory offers cytogenetic and molecular diagnosis for both constitutional and acquired chromosome abnormalities.

Our research has focused on the detection and characterization of subtle chromosome abnormalities in hematological malignancies as well as roles of telomere biology in cancer development and formation.

Clinical Speciality:

  • American Board of Medical Genetics certified Clinical Cytogeneticist
  • American Board of Medical Genetics certified Clinical Molecular Geneticist

Publications:

Peer-reviewed Journal Articles (selected from in a total of 50):

Zou Y., Lu BM., Lang JH. Comparison of four methods for the generation of immunoreactive fragments of a Monoclonal antibody (mAb) OC859 reactive with human ovarian epithelial cancer antigen. J. Chinese Med. Sci. (in English) 10:78-98, 1995.

Wang P., Zhou RH., Zou Y., Jackson-Cook C., Povirk L. Highly conservative reciprocal translocations formed by apparent joining of exchanged DNA double-strand break ends. Proc. Natl. Acad. Sci. (USA) 94:12018-12023, 1997.

Zhou R., Wang P., Zou Y., Jackson-Cook C., Povirk L. A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by Topoisomer-ase II amsacrine-treated Chinese hamster ovary cells. Cancer Res. 57:4699-4702, 1997.

Baur J., Zou Y., Shay J., Wright W. Telomere position effect in human cells. Science 292: 2075 â?"2077, 2001.

Ford L., Zou Y., Shay J., Wright W. Telomerase can inhibit the recombination-based pathway of recombination-based pathway of telomere maintenance in human cells. J. Biol. Chem.276:32198-32203, 2001.

Zou Y., Yi X., Wright W., Shay J., Human telomerase can immortalize Indian muntjac cells. Exp. Cell Res. 281:63-76, 2002.

Wang P., Lee JW., Yu Y., Turner K., Zou Y., Jackson-Cook CK., Povirk LF. Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostation: conservative non-homologous reciprocal exchanges in an otherwise stable genome. Nuclei Acids Res. 30:2639-2646, 2002.

Ramirez R., Herbert B., Vaughan M., Zou Y., Wright W., Shay J. Bypass of telomere-dependent replicative senescence (M1) upon over-expression of CDK4 in normal human epithelial cells. Oncogene 22:433-444, 2003.

Jackson-Cook C., Zou Y., Turner K., Ware J. A novel tumorigenic human prostate epithelial cell Line (M2205): molecular cytogenetic characterization demonstrates c-myc amplification and jumping translocations. Cancer Genet. Cytogenet. 141:56-64, 2003.

Bechter O., Zou Y., Shay J., Wright W. Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency. EMBO Rep. 4:1138-1143, 2003.

Zou Y., Wright W., Shay J., Cornforth M. Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes. Proc. Nat. Acad. Sci. (USA) 101:12928-12933, 2004.

Zou Y., Sfeir A., Gryaznov S., Shay J., Wright W. Does a sentinel or a subset of short telomeres determine replicative senescence? Mol. Biol. Cell. 15: 3709-3718, 2004.

Bechter O., Zou Y., Wright W., Shay J. Telomeric recombination in mismatch repair deficient human colon cancer cells following telomerase inhibition. Cancer Res. 64: 3444-3451, 2004.

Zou Y., Van Dyke DL., Chhabra HS., Uphoff TS., Keefe JG., Lega MA., Feely MA., Thorland EC., Jalal SM. A case of mosaic ring 20 with no detectable deletion by FISH analysis: literature review and the etiology of the seizure disorder. Am. J. Med. Genet. 140A:1696-1706, 2006

Zou Y., McGrann PS., Uphoff TS., Van Dyke DL. A case of mosaic ring supernumerary marker chromosome 15 with two copies of the segment 15p11.1-q14 region. Am. J. Med. Genet. 140A:1663-1668, 2006

Van Dyke DL., Ebrahim SA., Al Saadi AA., Powell SA., Zenger-Hain JL., Micale MA., Wiktor AE., Zou Y. The impact of maternal serum screening programs for Down syndrome in southeast Michigan, 1988-2003. Prenat Diagn. 27(6):583-584, 2007.

Zou Y., Fink S., Stockero K., Paternoster S., Smoley S., Tun H., Reeder CB., Tefferi A., Dewald GW. Efficacy of conventional cytogenetics and FISH for EGR1 to detect deletion 5q in hematological disorders and to assess response to treatment with Lenalidomide. Leukemia Res. 31:1193-1197, 2007.

Zhao Y, Sfeir AJ, Zou Y., Buseman CM, Chow TT, Shay JW, Wright WE. Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell, 138:463-475, 2009.

Zou Y., Misri S., Shay J., Pandita T., Wright W. Altered states of telomere deprotection and the two-stage mechanism of replicative aging. Mol. Cell Biol. 29:2390-2397, 2009.

Lee J., Yang S., Zou Y., Joseph L. The first case of erythroid/B-cell biphenotypic acute leukemia. Leukemia. 23:1920-1923, 2009.

Sheridan M, Kato T, Haldeman-Englert C, Jalali G, Milunsky J, Zou Y., Klaes R, Gimelli G, Gemmill R, Drabkin H, Hacker1 A, Brown J, Tomkins D, Shaikh1 T, Kurahashi H, Zackai1 E, Emanuel1 B. A palindrome-mediated recurrent translocation with 3:1 meiotic non-disjunction: The t(8;22)(q24.13;q11.21). Am J Hum Genet. 87:209-218, 2010.

Huang XL*, Zou Y.*, Maher T, Newton S., Milunsky J. A new de novo balanced translocation breakpoint truncating the autism susceptibility candidate 2 (AUTS2) gene in a patient with autism. Am. J. Med. Genet. 152A:2115-2119. *Co-first authors, 2010

Martin J, Saleki R, Christensen T, Liu W, Schappert J, Zou Y. Familial 25.3 Mb inverted duplication of bands q32.1 to q35.1 on chromosome 4 with psychomoter retardation. Am. J. Med. Genet 158A:2624-2628, 2012.

Zou Y., Ouahchi K, Lu Y, Liu W, Christensen T, Schappert J, Saleki R. Jumping translocations of 3q21 in an acute monocytic leukemia (M5) patient reveal mechanisms of multistage telomere shortening in pathogenesis of AML. Leukemia Res. 36:e31-33, 2012

Hodge JC, Mitchell E, Pillalamarri V, Toler T, Bartel F, Kearney H, Zou YS, et al. Highly penetrant psychopathology and diagnostic overlap with multiple syndromes resulting from MBD5 disruption. Mol. Pshchiatry 2013 Apr 16. doi: 10.1038/mp.2013.42. [Epub ahead of print]

Ghayee HK, Bhagwandin VJ, Stastny V, Click A, Ding LH, Mizrachi D, Zou YS, Chari R, Lam WL, Bachoo RM, Smith AL, Story MD, Sidhu S, Robinson BG, Nwariaku FE, Gazdar AF, Auchus RJ, Shay JW. Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor. PLoS One 2013 Jun 13. 8(6):e65624. doi: 10.1371 [Epub ahead of print]