Dr. Escano obtained his Doctor of Veterinary Medicine degree from the University of the Philippines and passed his licensure examinations both in the Philippines and here in the United States. He joined the laboratory of Dr. Pedro Jose in 2003 and tasked to perform micro-surgeries in rodent models of hypertension. Through the years, he has honed his skills and learned new in vivo techniques in pursuit of understanding the genetic underpinnings of essential hypertension and salt sensitivity. Dr. Escano assisted in the conceptualization and validation of a newly developed targeted gene silencing technique that works through the infusion of siRNA via osmotic minipump into the kidney or GI tract of the mouse. He has published more than 15 papers in refereed journals.
As a practicing veterinarian and (large and small animal) surgeon adept at performing complicated surgical procedures, Dr Escano is keenly interested in how dietary salt impacts an individual’s well-being and how individuals differ in the manner by which they handle salt. He is involved in several research projects that endeavor to unravel the genetic basis of salt sensitivity and describe the multiple layers of regulatory mechanisms involved in renal and gastro-intestinal handling of sodium and other electrolytes.
1996-2002: Doctor of Veterinary Medicine, University of the Philippines
Selected Journal Articles
Armando I, Wang X, Villar VA, Jones JE, Asico LD, Escano C, and Jose PA. Reactive Oxygen Species-dependent Hypertension in Dopamine D2 receptor-deficient Mice. Hypertension. 2007 Mar;49(3):672-8.
Li H, Armando I, Yu P, Escano C, Mueller SC, Asico L, Pascua A, Lu Q, Wang X, Villar VA, Jones JE, Wang Z, Periasamy A, Lau YS, Soares-da-Silva P, Creswell K, Guillemette G, Sibley DR, Eisner G, Felder RA, Jose PA. Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells. J Clin Invest. 2008 Jun 2;118(6):2180-2189.
Escano CS Jr, Keever LB, Gutweiler AA, Andresen BT. Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation. J Pharmacol Exp Ther. 2008 Jan;324(1):34-42
Xu Q, Wells CC, Garman JH, Asico L, Escano CS, Maric C. Imbalance in sex hormone levels exacerbates diabetic renal disease. Hypertension. 2008 Apr;51(4):1218-24.
Escano CS, Armando I, Wang X, Asico LD, Pascua A, Yang Y, Wang Z, Lau YS, Jose PA. Renal dopaminergic defect in C57Bl/6J mice. Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1660-9.
Wang X, Luo Y, Escano CS, Yang Z, Asico L, Li H, Jones JE, Armando I, Lu Q, Sibley DR, Eisner GM, Jose PA. Upregulation of renal sodium transporters in D5 dopamine receptor-deficient mice. Hypertension. 2010 Jun;55(6):1431-7
Asico L, Zhang X, Jiang J, Cabrera D, Escano CS, Sibley DR, Wang X, Yang Y, Mannon R, Jones JE, Armando I, Jose PA. Lack of renal dopamine D5 receptors promotes hypertension. J Am Soc Nephrol. 2011 Jan;22(1):82-9.
Li Z, Xie WB, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY. Response gene to complement 32 is essential for fibroblast activation in renal fibrosis. J Biol Chem. 2011 Dec 2;286(48):41323-30.
Zhang Y, Cuevas S, Asico LD, Escano C, Yang Y, Pascua AM, Wang X, Jones JE, Grandy D, Eisner G, Jose PA, Armando I. Deficient dopamine D2 receptor function causes renal inflammation independently of high blood pressure. PLoS One. 2012;7(6):e38745.
Villar VA, Jones JE, Armando I, Asico LD, Escano CS Jr, Lee H, Wang X, Yang Y, Pascua-Crusan AM, Palmes-Saloma CP, Felder RA, Jose PA. Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. J Biol Chem. 2012 Nov 14 (doi: 10.1074/jbc.M112.428458).
Tuchman S, Asico LD, Escano C, Bobb DA, Ray PE. Development of an animal model of nephrocalcinosis via selective dietary sodium and chloride depletion. Pediatr Res. 2012 Nov 22. doi: 10.1038/pr.2012.172
Note: Escano C, Escano CS, and Escano CS Jr. refer to the same person.