After completing his fellowship in cardiology, Dr. Fisher enjoyed a productive career at Case Western Reserve University in Cleveland, Ohio, before joining the University of Maryland School of Medicine faculty in 2011.
Dr. Fisher’s research interests revolve around the regulation of gene expression in relation to (a) vascular smooth muscle adaptations to altered blood flow and (b) tissue hypoxia and heart morphogenesis. Blood flow investigations focus on the regulated expression of myosin phosphatase (MP) and related contractile proteins in various models of disease in setting the sensitivity of vascular smooth muscle to signals that regulate blood flow, such as nitric oxide, reactive oxygen species, and the sympathetic nervous system. In the area of tissue hypoxia and heart morphogenesis, his research group has identified tissue oxygen gradients in the developing heart and proposed that they are required for apoptosis-dependent remodeling and patterning of the cardiac outlet structures. In addition, they may also predispose individuals to congenital heart defects.
Dr. Fisher’s laboratory work uses various techniques and equipment, including knock-out animal models; surgical models such as arterial ligations and hypoxic stress; and molecular biology techniques such as polymerase chain reaction (PCR), real-time PCR, Western blot, immunohistochemistry (IHC), plasmid cloning, subcloning and mutagenesis, RNA-protein binding assays, arrays, and immunoprecipitation. Physiology studies are conducted using vessel contractility in wire myograph and echocardiography for cardiac structure and blood flow. Bioinformatic analyses are used to assess study results.
Dr. Fisher is board certified in Internal Medicine and Cardiovascular Medicine.
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