- 1978: B.A., Central High School of Philadelphia
1982: B.A., University of Pennsylvania
- 1986: M.D., University of Pennsylvania
Post Graduate Education & Training
- 1986-1989: Internal Medicine Residen, University of Pittsburgh Presbyterian University Hospital
- 1989-1993: Cardiology Fellow, Medical Center Hospital and University of Vermont
- Internal Medicine - 1991
- Cardiovascular Medicine -1993; re-certified 2004
- 1993-2011: Case Western Reserve University
- 2011-present: University of Maryland School of Medicine
Regulation of Gene Expression and:
- Vascular smooth muscle adaptations to altered blood flow with a focus on myosin phosphatase (MP). The working model is that alterantive splicing of MP under the control of Transformer proteins sets the sensitivity of VSM to signals that regulate blood flow, e.g. NO/cGMP.
- Tissue hypoxia and heart morphogenesis. We have identified tissue oxygen gradients in the developing heart and proposed that these:
- are required for apoptosis-dependent remodeling and patterning of the cardiac outlet structures
- pre-dispose to congenital heart defects.
Lab Techniques and Equipment:
- Mouse models: conditional gene knock-out, creation of new knock-out models. Surgical models: arterial ligations, hypoxic stress Molecular biology: PCR, real-time PCR, Western blot, IHC, plasmid cloning, sub-cloning and mutagenesis, RNA-protein binding assays, arrays, IP etc.
- Bioinformatic analyses
- Physiology: vessel contractility in wire myograph; ECHO for cardiac structure and blood flow
Grants & Contracts:
- 2/10-1/14: Steven A Fisher, Smooth muscle myosin phosphatase subunit isoforms, NIH/NHLBI R01 HL66171
- 7/10-6/14: P.I. Steven A Fisher, Tissue hypoxia in cardiac morphogenesis, NIH/NHLBI R01 HL65314
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