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Enrico  Bucci
 

Enrico Bucci M.D., Ph.D., M.D.

Academic Title: Professor Emeritus
Primary Appointment: Biochemistry and Molecular Biology
ebucci@umaryland.edu
Location: 108NG RM 239
Phone: (410) 706-6380
Fax: (410) 706-8297

Research Interests:

We studied the structure function relationships in hemoglobin. The research is multifaceted and involves all the technologies of protein isolation, purification, peptide analyses and amino acid sequences. This in turn includes measurements of binding of oxygen, carbon monoxyde, cyanide and other ligands to hemoglobin and myoglobin. It also include measurements of molecular weight, molecular radius, optical characteristics (CD, absorption), fluorescence emission. One of the ultimate goals is to transform hemoglobin into a cell-free oxygen carrier to be used in transfusional fluids. A new field of study has been opened using fluorescence with time resolution in the picosecond range, namely the interactions of heme with the respective protein in hemoglobin and myoglobin.

Publications:

Bucci, E., Razynska, A., Kwansa, H., Matheson-Urbaitis, B., O’Hearne, M., Ulatowski, J.A., and Koehler, R.C. Production and characteristics of an infusible oxygen-carrying fluid based on hemoglobin intramolecularly cross-linked with sebacic acid. J. Lab. Clin. Med.  128:146-153, 1996.