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David K Klassen

David K Klassen M.D.

Academic Title: Professor
Primary Appointment: Medicine
Location: UMMC, Room N3W143F
Phone: (410) 328-5720
Fax: (410) 328-5685

Personal History:

Dr. Klassen is a Professor in the division of Nephrology. He received his medical degree from the Ohio State University and his Internal Medicine and Nephrology training at the Johns Hopkins Hospital. He has been a faculty member at the University of Maryland School of Medicine since 1986. He is a member of numerous professional societies and has served as the Chairman of the Medical Advisory Board of the National Kidney Foundation – Maryland. He is on the Board of Directors of the United Network for Organ Sharing (UNOS) and has served on the the UNOS Kidney committee and the Membership and Professional Standards Committee. He is the Medical Director of the Kidney and Pancreas Transplant Programs at the University of Maryland Hospital.

Research Interests:

Dr Klassen’s research interests are in kidney and pancreas transplantation including approaches to immunosuppression, the diagnosis and treatment of rejection, mechanisms of action of immunosuppressive drugs, and complications of chronic immunosuppression. Additionally he is interested in composite tissue allograft transplantation.

Clinical Speciality:

Dr. Klassen’s clinical interests focus on kidney transplantation, pancreas transplantation, and combined kidney/pancreas transplantation. This includes the diagnosis and management of acute problems related to transplantation as well as long-term management of transplant recipients. He also has interests in composite tissue allograft transplantation and general Nephrology including diagnosis and management of early renal disease prior to dialysis and management of hypertension.


Recent Publications

Munivenkatappa R, Haririan A, Papadimitriou JC, Drachenberg CB, Garcia Lopez C, Dinits-Pensy M, Klassen DK. Tubular epithelial cell and podocyte apoptosis with de novo sirolimus based immunosuppression in renal allograft recipients with DGF. Histo Histopath 2010; 25:189-196.

Nogueira JM, Weir MR, Jacobs S, Breault D, Klassen D, Evans DA, Bartlett ST, Cooper M. A study of renal outcomes in obese living kidney donors. Transplantation 2010; 90:993-9.

Haririan A, Nogueira JM, Zandi-Nejad K, Aiyer R, HurleyH, Cooper M, Klassen DK, Weir MR. The independent association between serum uric acid and graft outcomes after kidney transplantation. Transplantation 2010; 89:573-579.

Papadimitriou JC, Drachenberg CB, Munivenkatappa R, Ramos E, Sailey C, Klassen DK, Haririan A. Glomerular inflammationin renal allograft biopsies after the first year: cell types and relationship with antibody-mediated rejection and graft outcome. Transplantation 2010; 90:1478-1485.

Haririan A, Metireddy M, Cangro C, Nogueira JM, Rasetto F, Cooper M, Klassen DK, Weir MR. Association of serum uric acid with graft survival after kidney transplantation: time-varying analysis. Am J Transplant 2011; 9:1943-1950.

Drachenberg CB, Torrealba JR, Nankivell BJ, Rangel EB, Bajema IM, Kim DU, Arend L, Bracamonte ER, Bromberg JS, Bruijn JA, Cantarovich D, Chapman JR, Farris AB, Gaber L, Goldberg JC, Haririan A, Honsova E, Iskander SS, Klassen DK, Kraus E, Lower F, Odorico J, Olsen JL, Mittalhenkle A, Munivenkatappa R, Paraskevas S, Papadimitriou JC, Randhawa P, Reinholt FP, Renaudin K, Revelo P, Ruiz P, Samaniego MD, Shapro R, Stratta RJ, Sutherland DE, Troxell ML, Voska L, Seshan SV, Racusen LC, Bartlett ST. Guidelines for the diagnosis of antibody-mediated rejection in pancreas allografts – updated Banff grading schema. Am J Transplant 2011; 9:1792-1802.

Jones H, Talwar M, Nogueira JM, Ugarte R, Cangro C, Rasheed H, Klassen DK, Weir MR, Haririan A. Anemia after kidney transplantation; its prevalence, risk factors, and independent association with graft and patient survival: a time-varying analysis. Transplantation 2012 Feb 28.

Journal Articles (Refereed)

Klassen DK, Sagone AL Jr. Evidence for both oxygen and non-oxygen dependent mechanisms of antibody sensitized target cell lysis by human monocytes. Blood 1980;56;985-992.

Sagone AL Jr., Klassen DK, Decker MA, Clark L, Metz EN. Characteristics of the metabolic response of human monocytes to red cell sensitized with anti-D alloantibodies. J Lab Clin Med 1981;98:382-395.

Klassen DK, Conkling PR, Sagone AL Jr. Activation of monocyte and granulocyte antibody-dependent cytotoxicity by phorbol myristate acetate. Infect Immun 1982;35:818-825.

Conkling PR, Klassen DK, Sagone AL Jr. Comparison of anti-body dependent cytotoxicity mediated by human polymorphonucle¬ar cells, monocytes, and alveolar macrophages. Blood 1982;60¬:1290.

Dang CV, Schlott WD, Watson AJS, Gimenez L, Klassen DK. Horseshoe kidney and renovascular hypertension responsive to percutaneous transluminal angioplasty. Annals Int Med 1985;102:70.

Gimenez LF, Watson AJ, Burrow CR, Olson JL, Klassen DK, Cooke CR. De novo diabetic nephropathy with functional impairment in a renal allograft. Am J Nephro 1986;6:378.

Watson AJ, Gimenez LF, Klassen DK, Stout RL, Whelton A. Calcium channel blockade in experimental amino glycoside nephrotoxicity. J Clin Pharm 1987;27:625-627.

Klassen DK, Stout RL, Spilman PS, Whelton A. Sulindac kinetics and effects on renal function and prostaglandin excretion in renal insuffi¬ciency. J Clin Pharm 1989;29:1037-1042.

Klassen DK, Solez K, Burdick JF. Effects of cyclosporin on human renal allograft renin and prostaglandin production.  Transplantation 1989, 47:1072-5

Weir MR, Klassen DK, Hoover N, Douglas FL. Preliminary observations of the acute effects of selective serum thrombox¬ane inhibition and angioten¬sin converting enzyme inhibition on blood pressure and renal hemodynamics in hypertensive humans.  J Clin Pharm 1989;29:1108-1116.

Whelton A, Stout RL, Spilman PS, Klassen DK. Renal effects of ibuprofen, piroxicam and sulindac in patients with asymptomat¬ic renal failure. Annals Int Med 1990;112:568-576.

Weir MR, Klassen DK, Shen SY, Sullivan D, Buddemeyer EU, Handwerger BS. Acute effects of intravenous cyclosp¬orine on blood pressure, renal hemodynam¬ics, and urine prostaglandin production of healthy humans. Transplantation 1990;49:41-47.

Klassen DK, Spivak JL. Hepatitis-Related Hepatic Erythropoietin Production. Amer J of Med 1990;89:684-686.
Weir MR, Klassen DK, Hall PS, Schubert C, Voss T, Stromatt S, Brown J. Minimization of indomethacin-induced reduction in renal function by misoprostol. J Clin Pharm 1991;31:729-735.

Weir MR, Klassen DK, Burdick JF. A pilot study to assess the ability of an orally available selective thromboxane synthase inhibitor to improve renal function in cyclosporine-treated renal transplant recipients1. J Am Soc Nephro 1992;2:1285-1290.

Klassen DK, Weir MR, Buddemeyer EU. Simultaneous measurements of glomerular filtration rate by two radioisoto¬pic methods and creatinine clearance in patients without renal impairment. J Am Soc Nephro 1992;3:108-112.

Burnett HW, Friedman R, Perell F, Weir MR, Klassen DK. The impact of chronic corticosteroid administration on intraocular pressure in renal transplant recipients. J Clin Tran 1992;6:¬199-201.

 Hise MK, Corteza Q, Klassen DK, Sadler JH. Influence of circulating insulin-like growth factor-I (IGF-I) versus intrarenal IGF-I on proximal nephron receptor density in rats. Clin Sci 1992;83:233-239.

Klassen DK, Goodfriend TL, Young DY, Peterson CA. Assessment of blood pressure during treatment with naproxen or ibuprofen in hypertensive patients treated with hydrochlorothiazide. J. Clin. Pharm.  1993,33:971-978.

Klassen DK, Jane LH, Young DY, Peterson CA. Assessment of Blood Pressure During Naproxen Therapy in Hypertensive Patients Treated with Nicardipine. Am J Hyperten. 1995;8:146-153

Klassen DK, Hoehn-Saric EW, Weir MR, Papadimitriou JC, Drachenberg CB, Johnson L, Schweitzer EJ, Bartlett ST.  Isolated Pancreas Rejection in Combined kidney Pancreas Transplantation. Transplantation  1996;61:974-977

Klassen AC, Klassen DK.  Who are the Donors in Organ Donation?  Annals Int. Med 1996;125:70-75.

Walker JA, Klassen DK, Hooper FJ, Hoehn-Saric EW, Schweitzer EJ, Johnson LB, Bartlett ST, Weir MR. Late Pancreas Allograft Rejection: Preliminary Experience With Factors Predisposing To Rejection.  Transplantation 1996;62:539-543.

Wong JJ, Krebs TL, Klassen DK, Daly B, Simon EM, Bartlett ST, Grumbach K, Drachenberg CB. Sonographic Evaluation Of Acute Pancreatic Transplant Rejection: Morphology/Doppler Analysis Versus Guided Percutaneous Biopsy. Am. J Roentology 1996;166(4):803-807.

Schweitzer EJ, Drachenberg CB, Anderson L, Papadimitriou JC, Johnson LB, Klassen DK, Hoehn-Saric EW, Weir MR, Bartlett ST.  Significance of the Baff Borderline Biopsy. Am J Kidney Dis 1996;28(4):585-588.

Drachenburg CB, Papadimitriou JC, Weir MR, Klassen DK, Hoehn-Saric EW, Bartlett ST. Histologic findings in islets of whole pancreas allografts: lack of evidence for recurrent cell-mediated diabetes mellitus. Transplantation 1996;62(12):1770-1772.

Malinow L, Walker J, Klassen DK , Oldach D, Schweitzer E, Bartlett ST, Weir MR. Antilymphocyte induction immunosuppression in the post-Minnesota anti-lymphocyte globulin era: incidence of renal dysfunction and delayed graft function. A single center experience.  Clinical Transplantation 1996;10(3):237-242.

Johnson LB, Kuo PC, Schweitzer EJ, Ratner LE, Klassen DK, Hoehn-Saric EW, de la Torre A, Weir MR, Strange J, Bartlett ST. Double renal allografts successfully increase utilization of kidneys from older donors within a single organ procurement organization. Transplantation 1996; 62(11):1581-1583.

Bartlett ST, Schweitzer EJ, Johnson LB, Kuo PC, Papadimitriou JC, Drachenburg CB, Klassen DK, Hoehn-Saric EW, Weir MR, Imbembo AL.  Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of tacrolimus immunosuppression with percutaneous biopsy. Annals of Surgery 1996;224(4):440-449; discussion 449-452.

Johnson LB, Kou PC, Dafoe DC, Schweitzer EJ, Alfrey EJ, Klassen DK, Hoehn-Saric EW, Weir MR, Bartlett ST. Double adult renal allografts: a technique for expansion of the cadaveric kidney donor pool.  Surgery 1996;120(4):580-583.

Drachenberg CB, Papadimitriou JC, Klassen DK, Racusen LC, Hoehn-Saric EW, Weir MR, Kuo PC, Schweitzer EJ, Johnson LB, Bartlett ST. Evaluation of Pancreas Transplant Needle Biopsy: Reproducibility and revision of histologic grading system. Transplantation 1997;63:1579-1586.

Klassen AC, Klassen DK. Ethics, mandated choice and organ donation. Annals of Int. Med. 1997;126:251-252. (Letter)

Schweitzer EJ, Anderson L, Kuo PC, Johnson LB, Klassen DK, Hoehn-Saric EW, Weir MR, Bartlett ST, Weir MR, Bartlett ST.  Safe pancreas transplantation in patients with coronary artery disease. Transplantation 1997;63:1294-1299.

Kuo PC, Johnson LB, Schweitzer EJ, Klassen DK, Hoehn-Saric EW, Weir MR, Drachenberg CB, Papadimitriou JC, Bartlett ST. Solitary pancreas allografts: the role of percutaneous biopsy and standardized histologic grading of rejection.  Archives Surg 1997;132:52-57.

Drachenberg CB, Steinberger E, Hoehn-Saric EW, Heffer A, Klassen DK, Bartlett ST, Papadimitriou JC. Specificity of intertubular capillary changes: comparative ultrastructural studies in renal allografts and native kidneys.  Ultrastructural path 1997;21:227-233.

Schweitzer EJ, Your S, Hart J, Anderson L, Barnes R, Evans D, Hartman K, Jaekels J, Johnson LB, Kuo PC, Hoehn-Saric E, Klassen DK, Weir MR, Bartlett ST.  Increased living donor volunteer rates with a formal recipient family education program. Am J. Kid Dis.1997;29:739-745.

Weir MR, Anderson L, Fink, JC, Gabregiorgish K, Schweitzer EJ, Hoehn-Saric E, Klassen, DK, Cangro CB, Johnson LB, Kuo PC, Lim JY, Bartlett ST. A novel approach to the treatment of chronic allograft nephropathy. Transplantation 1997;64:1706-10

Klassen DK. Chronic rejection in pancreas transplantation. Graft 1998; 1(Suppl II) 74-76

Drachenburg CB, Abruzzo, LV, Klassen DK, Bartlett, ST. Johnson, LB, Kuo, PC, Kumar D, Papadimitriou, JC, Epstein-Barr virus-related post-transplantation lymphoproliferative disorder involving pancreas allografts: Histological differential diagnosis from acute rejection. Human Pathol. 1998;29:569-77

Klassen AC, Klassen DK, Brookmeyer R, Frank RG, Marcani K. Factors influencing waiting time and successful receipt of cadaveric liver transplant in the United States: 1990-1992. Med Care 1998; 36:281-94

Keay S, Oldach D, Wiland A, Klassen DK, Schweitzer E, Abruzzo LV, Kumar D, Bartlett S. Posttransplantation lymphoproliferative disorder associated with OKT3 and decreased antiviral prophylaxis in pancreas transplant recipients.  Clin Infect Dis 1998;26(3):596-600.

Papadimitriou JC, Drachenberg CB, Wiland A, Klassen DK, Fink J, Weir MR, Cangro C, Schweitzer EJ, Bartlett ST.  Histological grading of acute allograft rejection in pancreas needle biopsy: correlation to serum enzymes, glycemia, and response to immunosuppressive treatment. Transplantation 1998;66(12):1741-5.

Drachenberg CB, Klassen DK, Weir MR, Wiland A, Fink JC, Bartlett ST, Cangro CB, Blahut S, Papadimitriou JC. Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 1999;68(3):396-402.

Drachenberg CB, Beskow CO, Cangro CB, Bourquin PM, Simsir A, Fink J, Weir MR, Klassen DK, Bartlett ST, Papadimitriou JC.  Human polyoma virus in renal allograft biopsies: morphological findings and correlation with urine cytology. Hum Pathol 1999;30(8):970-7.

Nogueira JM, Cangro CB, Fink JC, Schweitzer E, Wiland E, Klassen DK, Gardner J, Flowers J, Jacobs S, Cho E, Philosophe B, Bartlett ST, Weir MR.  A comparison of recipient renal outcomes with laparoscopic versus open live donor nephrectomy. Transplantation 1999;67(5):722-8.

Klassen AC, Klassen DK, Aronoff R, Hall AG, Braslow J. Organizational characteristics of solid-organ donor hospitals and nondonor hospitals. J Transplant Coord. 1999;9:87-96.

Klassen DK, Drachenberg CB, Papadimitriou JC, Cangro CB, Fink JC, Bartlett ST, Weir MR. CMV allograft pancreatitis: diagnosis, treatment, and histological features.  Transplantation 2000; 69: 1968-1979

Oh JM, Wiland AM, Klassen DK, Weidle PJ, Bartlett ST. Comparison of Azathioprine and Mycophenolate Mofetil for the Prevention of Acute Rejection in Recipients of Pancreas Transplantation. J Clin Pharmacol 2001;41:1-9.

Weir MR, Ward MT, Blahut SA, Klassen DK, Cangro CB, Bartlett ST, Fink JC. Long-Term Impact Of Discontinued Or Reduced Calcineurin Inhibitor In Patients With Chronic Allograft Nephropathy. Kidney Int. 2001; 59: 1567 – 1573.

Drachenberg RC, Drachenberg CB, Papadimitriou JC, Ramos E, Fink JC, Wali R, Cangro CB, Klassen, DK, Khaled A, Cunningham R, Bartlett ST. Morphological Spectrum of Polyoma Virus Disease In Renal Allografts: Diagnostic accuracy of urine cytology. Am J. Transplantation 2001; 1:373-381.

Hankey KG, Drachenberg CB, Papadimitriou JC, Klassen DK, Philosophe B, Bartlett ST, Groh, V, Spies T, Mann DL, MICA/MICB Expression in Renal and Pancreatic Allografts. Transplantation 2002; 73:304-306.

Klassen DK, Weir MR, Cangro CB, Bartlett ST, Papadimitriou JC, Drachenberg CB. Pancreas Allograft Biopsy: Safety of Percutaneous Biopsy, Results of a Large Experience. Transplantation 2002; 73:553-555.

Klassen AC, Hall AG, Saksvig B, Curbow B, Klassen DK. The relationship between patients perspective on disadvantage and discrimination and listing for kidney transplant. Am J Public Health 2002; 92:811-817.

Haririan A, Ramos ER, Drachenberg CB, Weir MR, Klassen DK. Polyomavirus Nephropathy in Native Kidneys of a Solitary Pancreas Transplant Recipient. Transplantation 2002; 73:1350-1353.

Onuigbo M, Haririan A, Ramos ER, Klassen DK, Wali R, Drachenberg CB. Cytomegalovirus - induced glomerular vasculopathy in renal allografts. Am J. Transplantation 2002; 7:684-688.

Ramos E, Drachenberg CB, Papadimitriou JC, Hamze O, Fink JC, Klassen DK, Drachenberg RC, Wiland A, Wali R, Cangro CB, Schweitzer E, Bartlett ST, Weir MR. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J Am Soc Nephrol 2002; 8:2145-2151.

Haririan A, Klassen DK. BK virus infection after nonrenal transplantation. Graft 2002; 5:S58-S64.

Haririan A, Hamze O, Drachenberg CB, Ramos E, Weir MR, Klassen DK. Polyomavirus reactivation in native kidneys of pancreas alone allograft recipients. Transplantation 2003; 75(8):1186-1190

Papadimitriou JC, Drachenberg CB, Klassen DK, Gaber L, Racusen LC, Voska L, Cangro CB, Ramos E, Wali R, Weir MR, Bartlett ST. Histological grading of chronic pancreas allograft rejection/graft sclerosis. Am J Transplant 2003; 3(5):599-605.

Papadimitriou JC; Cangro CB, Lustberg A; Khaled A; Nogueira J; Wiland A; Ramos E; Klassen DK; Drachenberg CB. Histologic features of mycophenolate mofetil-related colitis: a graft-versus-host disease-like pattern. Int J Surg Pathol 2003; 11(4):295-302.

Weir MR, Blahut S, Drachenberg CB, Young C, Papadimitriou J, Klassen DK, Cangro CB, Bartlett ST, Fink JC. Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant function. Am J Nephrol 2004 24 (4): 379-386.