Lab Techniques and Equipment:
Flow Sorting Core Facility
Noriko Sato, Helen Sabzevari, Song Fu, Wei Ju, Michael N. Petrus, Richard N. Bamford, Thomas A. Waldmann and Yutaka Tagaya. Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15 transgenic mice requires the cis-expression of IL-15Ralpha. Blood (in press)
Fumi Miyagawa, Yutaka Tagaya, Brian S Kim, Hiral J Patel, Kazuto Ishida , Toshiaki Ohteki, Thomas A Waldmann , and Stephen I Katz. IL-15 serves as a co-stimulator in determining the activity of autoreactive CD8 Tcells in an experimental mouse model of graft vs. host like disease. J. Immunol. 2008 181: 1109-19
Noriko Sato, Hiral J. Patel, Thomas A. Waldmann, and Yutaka Tagaya The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 T cells. Proc. Natl. Acad. Sci. USA 2007 104: 588-593
Hisataka Kobayashi, Sigrid Dubois, Noriko Sato, Helen Sabzevari, Yoshio Sakai, Thomas A. Waldmann, and Yutaka Tagaya. The role of trans-cellular IL-15-presentation in the activation of NK-mediated killing, which leads to enhanced tumor immunesurveillance Blood, 2005 105: 721 - 727
Sigrid Dubois, Jennifer Mariner, Thomas A. Waldmann, and Yutaka Tagaya. IL-15Ralpha recycles and presents IL-15 in trans to neighboring cells. Immunity 2002 17: 537-547
Joanna Marks-Konczalik, Sigrid Dubois, Helen Sabzevari, Nobuo Yamada, Lionel Feigenbaum, Thomas A. Waldmann, and Yutaka Tagaya. IL-2 induced activation-induced cell death is inhibited in IL-15 Transgenic mice. Proc. Natl. Acad. Sci. 2000 97:11445-11450
Kouetsu Ogasawara, Shigeaki Hida, Nazli Azimi, Yutaka Tagaya, Takeo Sato, Taeko Yokochi-Fukuda, Thomas A. Waldmann, Tadatsugu Taniguchi, and Shinsuke Taki (1998) Requirement for IRF-1 in the microenvironment development of natural killer cells. Nature 391: 700-703
Yutaka Tagaya, Jack D. Burton, Yoshihisa Miyamoto, and Thomas A. Waldmann. (1996) Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells. EMBO J. 15: 4928-4939.
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