Chronic Kidney Disease (CKD) is an increasingly important cause of morbidity and mortality among all racial groups but particularly Native and African Americans. The rising incidence of the metabolic syndrome plays an important role in this increase. In vulnerable populations such as the elderly, vaccines reduce the rates of hospitalization, all cause mortality and interestingly cardiovascular events. One of my current interests is the mechanism through which these benefits accrue and how they might be best used as a therapeutic tool.
A second interest of mine is the role of exercise in reducing cardiovascular events in patients with CKD. It is well known that exercise reduces all-cause mortality and cardiovascular events. Interestingly, recent prospective studies have demonstrated that exercise also reduces the progression of mental deterioration in the elderly. Although cardiovascular events occur with increasing frequency in patients with CKD, the role of exercise as a treatment of these patients has not be adequately addressed.
Dinits-Pensy M, Forrest GN, Cross AS, Hise MK: The use of vaccines in adult patients with renal disease. Am J Kidney Dis 46:997-1011, 2005.
Palmer BF and Hise MK. Management of Chronic Kidney Disease. In ACP Medicine. American College of Physicians. David C. Dale and Daniel D. Federman editors. WebMD Professional Publishing New York, pp 2008-2018, 2006.
Finkelstein J, Joshi A, Mann D, Hise MK. Association of physical activity and renal function in subjects with and without the metabolic syndrome: A review of the Third National Health and Nutritional Examination Survey (NHANES). In review.