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Steven J Kittner
 

Steven J Kittner M.D., M.P.H.

Academic Title: Professor
Primary Appointment: Neurology
Secondary Appointments: Epidemiology & Public Health
skittner@umaryland.edu
Location: Bressler Research Building, 12-006
Phone: (410) 328-6485 (office)
Phone: (410) 706-0414 (lab)
Fax: (410) 706-0816

Personal History:

Honors

  • 1975: Brown University Dean's Scholar, Phi Beta Kappa, Sigma XI
  • 1995: Elected to American Epidemiological Society
  • 1998: Golden Hammer Award for Dedication to Patient Care and Excellence in Neurologic Teaching
  • 2000: Elected to American Neurological Association 
  • 2003-2011: Selected annually by peers to be included in Best Doctors in America
  • 2007: E. David Gibbons Memorial Research Award from the American Heart Association

Other Experience and Professional Memberships

  • 1992, 2000: Invited Expert, FDA, Stroke Risk Associated with Phenylpropanolamine
  • 1995-1998: Epidemiology and Disease Control (EDC-2) Study Section Member (Acting Chair, 1996-1997)
  • 1996: Member, American Heart Association Consensus Panel on Stroke Risk Factors
  • 2000-11: Grant reviewer for American Federation of Aging Research (2000), American Heart Association (2000, 2011) & Wellcome Trust (2001), Veterans Affairs Administration (2002-06)
  • 2001-present: Stroke Statistics Committee of the Epidemiology and Prevention Council, American Heart Association (Chair 2009-11)
  • 2002: Co-Chair, Genetics and Vascular Biology Panel, NINDS Working Group on Racial and Ethnic Disparities in Stroke Risk
  • 2004-2005: Functional Genomics Interdisciplinary Working Group Steering Committee, American Heart Association
  • 2008: Founding Member, International Stroke Genetics Consortium

Research Interests:

Dr. Kittner’s clinical interests are cerebrovascular diseases, particularly stroke in young adults, and prevention of recurrent stroke in all age groups. Dr. Kittner’s research interests are the epidemiology of cerebrovascular disease, especially the study of genetic risk factors for ischemic stroke.

Clinical Speciality:

Neurology with a subspecialty in Vascular Neurology


Current Grant Support:

National Institute of Neurological Diseases and Stroke

1U01NS069208
3/2010 – 2/2014
Kittner (Administrative PI)
The NINDS Ischemic Stroke Genetics Consortium

The major goal of this project is to 1) establish a consortium to perform a large sample size genome-wide association study for ischemic stroke using both previously genotyped and samples that need genotyping 2) replicate and extend findings from discovery sample through international collaboration with other genome-wide association studies.

Department of Veterans Affairs

2007-2011
Merit Review Grant, Kittner (PI)
Genetic Susceptibility to Early-Onset Stroke

The major goals of this collaborative project with Morehouse University School of Medicine is to clone and characterize novel genes at the same genomic locus as the PDE4D7 gene, and to determine the effect of individual polymorphisms and common haplotypes of these new genes on stroke susceptibility in African-Americans and Caucasians.

National Human Genome Research Institute

1U01HG004436-01A1
09/20/2008 – 06/30/2011
Mitchell (PI), Kittner (Co-Investigator)
Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic Groups

The major goal of this project is to perform a genome-wide association study of early-onset ischemic stroke and to examine for gene-by-environment interactions with cigarette smoking.


Publications:

Search My Publications in Pub Med

Highlighted Publications

Hamedani AG, Cole JW, Mitchell BD, Kittner SJ. Meta-analysis of factor V Leiden and ischemic stroke in young adults: the importance of case ascertainment. Stroke. 2010;41:1599-603.

Wozniak MA, Kittner SJ, Tuhrim S, Cole JW, Stern B, Dobbins M, Grace ME, Nazarenko I, Dobrovolny R, McDade E, Desnick RJ. Frequency of Unrecognized Fabry Disease among Young European-American and African-American Men with First Ischemic Stroke. Stroke. 2010;41:78-81.

The International Stroke Genetics Consortium and the Wellcome Trust Case-Control Consortium 2. Failure to Validate Association between Variants on 12p13 and Ischemic Stroke. New England Journal of Medicine 362:1547-1550, 2010.

Gschwendtner S, Bevan S, Cole JW, Plourde A, Matarin, Ross-Adams H, Meitinger T, Wichmann E, Mitchell BD, Furie K, Slowik A, Rich SS, Syme PD, MacLeod MJ, Meschia JF, Rosand J, Kittner SJ, Markus HS, Müller-Myhsok B, Dichgans M on behalf of the Ischemic Stroke Genetics Consortium. Sequence variants on chromosome 9p21.3 confer risk of atherosclerotic stroke. Ann Neurol. 2009;65:531-9.

Macclellan L , Howard TD, Cole JW, Stine OC, Giles WH, O'Connell JR, Wozniak MA, Stern BJ, Mitchell BD, Kittner SJ. Relation of Candidate Genes that Encode for Endothelial Function to Migraine and Stroke. The Stroke Prevention in Young Women Study. Stroke. 2009;40:e550-7.

Helms A, Drogan O, Kittner SJ. First trimester stroke prophylaxis in pregnant women with a history of stroke. Stroke. 2009;40:1158-61.

Bhat JM, Cole JW, Sorkin JD, Wozniak MA, Malarcher AM, Giles WH, Stern BJ, Kittner SJ. Dose-response relationship between cigarette smoking and risk of ischemic stroke in young women. Stroke 2008.  Sep;39(9):2439-43.

Cole JW, Brown DW, Giles WH, Stine OC, O'Connell JR, Mitchell BD, Sorkin JD, Wozniak MA, Stern BJ, Sparks MJ, Dobbins MT, Shoffner LT, Zappala NK, Reinhart LJ and Kittner SJ. Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: The Stroke Prevention in Young Women Study. Thromb J. 2008 Aug 26;6:11.

Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008 Jan 29;117(4):e25-146. Epub 2007 Dec 17.

MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, Kittner SJ. Probable migraine with visual symptoms and risk of ischemic stroke: The Stroke Prevention in Young Women Study. Stroke. 2007;38(9):2438-45.

Song Q, Cole JW, O'Connell, JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdle PF, Naj AC, Qin Xu Q, Gibbons GH, Kittner SJ. Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: The Stroke Prevention in Young Women Study. Human Molecular Genetics. 2006, 15(16):2468-2478.

MacClellan LR, Mitchell BD, Cole JW, Wozniak MA, Stern BJ, Giles WH, Brown DW, Sparks MJ, Kittner SJ. Familial aggregation of ischemic stroke in young women: The Stroke Prevention in Young Women Study. Genet Epidemiol. 2006; 30:602-608.

Brown DW, Dueker N, Jamieson DJ, Cole JW, Wozniak MA, Stern BJ, Giles WH, Kittner SJ. Preeclampsia and the risk of ischemic stroke among young women. Results from the Stroke Prevention in Young Women Study. Stroke. 2006;37(4):1055-1059.

Howard TD, Giles WH, Xu J, Wozniak MA, Malarcher AM, Lange LA, Macko RF, Baschore MJ, Meyers DA, Cole JW, Kittner SJ. Promoter Polymorphisms in Endothelial Nitric Oxide Synthase and Risk of Ischemic Stroke: The Stroke Prevention in Young Women Study. Stroke 2005;36:1848-1853.

Cole JW, Pinto AN, Hebel JR, Buchholz DW, Earley CJ, Johnson CJ, Macko RF, Price TR, Sloan MA, Stern BJ, Wityk RJ, Wozniak MA, Kittner SJ. Acquired immunodeficiency syndrome and the risk of stroke. Stroke. 2004;35:51-6.

Gorelick PB, Richardson D, Kelly M, Ruland S, Hung E, Harris Y, Kittner S, Leurgans S. Aspirin and Ticlopidine for Prevention of Recurrent Stroke in Black Patients - A Randomized Trial. JAMA 2003: Vol. 289, 22:2947-2957.

Macko RF, Kittner SJ, Ivey FM, Epstein A, Sparks MJ, Hebel JR, Johnson CC, Wityk RJ, Ueland PM, Refsum H. Effects of vitamin therapy on plasma total homocysteine, endothelial injury markers, and endogenous fibrinolysis in stroke patients. Journal of Stroke and Cerebrovascular Diseases. 2002; 11:1-8.

Brey RL, Stallworth CL, McGlasson DL, Wozniak MA, Wityk RJ,Stern BJ, Sloan MA, Sherwin R, Price TR, Macko RF Johnson CJ, Earley CJ, Buchholz DW, Hebel JR, Kittner SJ. Antiphospholipid Antibodies and Stroke in Young Women. Stroke. 2002; 33:2396-401.

Ayala C, Greenlund KJ, Croft JB, Keenan NL, Donehoo RS, Giles WH, Kittner SJ, Marks JS. Racial/Ethnic Disparities in Mortality by Stroke Subtype in the United States, 1995-98. Am J Epidemiol. 2001;154:1057-1063.

Brey RL, Abbott RD, Curb JD, Sharp DS, Ross GW. Stallworth CL, Kittner SJ. B2-Glycoprotein 1-Dependent Anticardiolipin Antibodies and Risk of Ischemic Stroke and Myocardial Infarction, Stroke 2001;32:1701-1706.

Malarcher AM, Giles WH, Croft JB, Wozniak MA, Wityk RJ, Stolley PD, Stern BJ, Sloan MA, Sherwin R, Price TR, Macko RF, Johnson CJ, Earley CJ, Buchholz DW, Kittner SJ. Alcohol intake, type of beverage, and the risk of cerebral infarction in young women. Stroke 2001;32:77-83.

Wityk RJ, Kittner SJ, Jenner JL, Hebel JR, Epstein A, Wozniak MA, Stolley PD, Stern BJ, Sloan MA, Price TR, McCarter RJ, Macko RF, Johnson CJ, Earley CJ, Buchholz DW, Schaefer EJ. Lipoprotein(a) and risk of ischemic stroke in young women. Atherosclerosis 2000; 150:389-396.

Magder LS, Sloan MA, Duh S, Abate J, Kittner SJ. Utilization of multiple sources of outcome information in logistic regression analysis. Statistics in Medicine 2000;19:99-111.

Macko RF, Kittner SJ, Epstein A, Cox DK, Wozniak MA, Wityk RJ, Stern BJ, Sloan MA, Sherwin R, Price TR, McCarter RJ, Johnson CJ, Earley CJ, Buchholz DW, Stolley, PD. Elevated tissue plasminogen activator antigen and stroke risk: the Stroke Prevention in Young Women Study. Stroke 1999;30:7-11.

Kittner SJ, Giles WH, Macko RF, Hebel JR, Wozniak MA, Wityk RJ, Stolley PD, Stern BJ, Sloan MA, Sherwin R, Price TR, McCarter RJ, Johnson CJ, Earley CJ, Buchholz DW, Malinow MR. Homocyst(e)ine and risk of cerebral infarction in a biracial population: The Stroke Prevention in Young Women Study. Stroke 1999 30:1554-60.

Kittner SJ, Stern BJ, Wozniak M, Buchholz DW, Earley CJ, Feeser BR, Johnson CJ, Macko RF, McCarter RJ, Price TR, Sherwin R, Sloan MA, Wityk RJ. Cerebral infarction in young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology 1998; 50:890-894.

Wagner KR, Giles WH, Johnson CJ, Ou C-Y, Bray PF, Goldschmidt-Clermont PJ, Croft JB, Brown VK, Stern BJ, Feeser BR, Buchholz DW, Earley CJ, Macko RF, McCarter RJ, Sloan MJ, Stolley PD, Wityk RJ, Wozniak MA, Price TR, Kittner SJ. Platelet glycoprotein receptor IIIa polymorphism P1A2 and ischemic stroke: the Stroke Prevention in Young Women Study. Stroke 1998;29:581-585.

Earley CJ, Kittner SJ, Feeser BR, Gardner J, Epstein A, Wozniak MA, Wityk R, Stern BJ, Price TR, Macko RF, Johnson C, Sloan MA, Buchholz D. Stroke in children - the importance of sickle cell disease: the Baltimore-Washington Cooperative Young Stroke Study. Neurology 1998;51:169-176.

Stewart A, Davis P, Kittner SJ, Langenberg P. The effect on risk estimates of excluding cases from a case-control study of ischemic stroke. Neuroepidemiology 1997;16:191-198.

Rohr J, Kittner SJ, Feeser B, Hebel JR, Whyte M, Weinstein A, Kanerak N, Buchholz D, Earley C, Johnson C, Macko R, Price T, Sloan M, Stern B, Wityk R, Wozniak M, Sherwin R. Traditional risk factors and ischemic stroke in young adults: The Baltimore-Washington Cooperative Young Stroke Study Arch Neur 1996;53:603-607.

Kittner SJ, Stern BS, Feeser BR, Hebel JR, Nagey DA, Buchholz DW, Earley CJ, Johnson CJ, Macko RF, Price TR, Sherwin R, Sloan MA, Wityk RJ, Wozniak MA. Pregnancy and the risk of stroke. New England Journal of Medicine 1996: 335:768-774.

Kittner SJ, White LR, Losonczy KG, Wolf PA, Hebel JR: Black-white differences in stroke incidence in a national sample: the contribution of hypertension and diabetes mellitus. JAMA 1990;264:1267-1270.

Kittner SJ, White L, Farmer ME, Wolz M, Kaplan E, Moes E, Brody JA, Feinleib M. Methodological issues in screening for dementia: the problem of education adjustment. Journal of Chronic Disease 1986; 3: 163 170.

UPDATED 1/22/2011