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Alan I. Faden
 

Alan I. Faden M.D.

Academic Title: Professor
Primary Appointment: Anesthesiology
Secondary Appointments: Anatomy and Neurobiology, Neurology, Neurosurgery, Psychiatry
afaden@anes.umm.edu
Location: HSF-II, S247
Phone: (410) 706-4205
Fax: (410) 706-1639
Lab: HSF II, Room 239, 241 and 263
 

Personal History:

Additional Titles

  • David S. Brown Professorship in Trauma
  • Director, Center for Shock, Trauma and Anesthesiology Research (STAR) & National Study Center for Trauma and EMS
  • Professor, Department of Organizational Systems & Adult Health, University of Maryland School of Nursing
  • Adjunct Professor of Neuroscience, Georgetown University Medical Center
  • Adjunct Professor of Pediatrics, George Washington University
  • Professor, (Affiliate) Department of Pharmaceutical Sciences

Education

  • 1962-1966: B.A. University of Pennsylvania, Physics (Honors)
  • 1966-1967: Graduate Studies, Indiana University, History & Philosophy of Science
  • 1967-1971: M.D. University of Chicago School of Medicine

Clinical Training

  • 1971-72: Intern in Medicine, Presbyterian-University of Pennsylvania Medical Center
  • 1972-74: Resident in Neurology, University of California, San Francisco (UCSF)
  • 1974-75: Chief Resident in Neurology, UCSF

Employment History

  • 1975: Instructor, Department of Neurology, University of California, San Francisco
  • 1975-1980: Research Neurologist, Walter Reed Army Institute of Research, Department of Medical Neurosciences, Washington, DC
  • 1977-1984: Uniformed Services University of the Health Sciences, Bethesda, MD
    Assistant Professor of Neurology (1977-78)
    Associate Professor of Neurology (1978-81) and Medicine (1980-81)
    Vice Chairman, Department of Neurology (1980-82)
    Professor of Neurology (1981-84) and Physiology (1983-84)
    Chief, Neurobiology Research Unit (1982-84)
  • 1984-1991: University of California, San Francisco
    Vice Chairman, Department of Neurology (1984-90)
    Chief, Neurology Service, Department of Veterans Affairs, San Francisco, CA(1984-90)
    Director, Center for Neural Injury (1984-91)
    Professor of Neurology in Residence (1984-91)
  • 1991-2009: Georgetown University, Washington, DC
    Dean of Research and Graduate Education, Medical Center (1991-96)
    Scientific Director, Medical Center (1991-96)
    Associate Dean for Biomedical Sciences, Graduate School (1991-96)
    Professor of Neurology and Pharmacology, Medical School(1991-2009)
    Director, Georgetown Institute for Cognitive and Computational Sciences (1995-98)
    Professor of Neuroscience (1999-2009)
  • 2009-present: University of Maryland School of Medicine, Baltimore, MD
    David S. Brown Professor in Trauma and Professor of Anesthesiology
    Director, Organized Research Center for Shock, Trauma and Anesthesiology Research (STAR Center)

Honors & Awards

  • 1975: Newman Award, San Francisco Neurological Society
  • 1979: Keynote Speaker, Infectious Disease Society of America
  • 1980: Outstanding Achievement Award for Research, United States Army Research and Development Command
  • 1982: 100 Top Young Leaders of Washington, Washingtonian Magazine
  • 1984: Exceptional Service Medal, Uniformed Services University of the Health Sciences
  • 1984: Keynote Address, Second International Symposium on the Spinal Cord
  • 1984: Keynote Address, American Osteopathic Association
  • 1986: Janssen Distinguished Lecturer, Society of Neurosurgical Anesthesia
  • 1987: Paralyzed Veterans of America Distinguished Lecturer, University of Washington
  • 1988-89: President, Neurotrauma Society
  • 1989, 2000: Knight Foundation Visiting Professor, University of Miami, School of Medicine
  • 1990-91: President, San Francisco Neurological Society
  • 1996: Faculty Convocation Address, Georgetown University
  • 2001: Distinguished Service Award, University of Chicago
  • 2002: Raine Lecturer, Sir Charles Gardner Hospital, Perth Australia
  • 2003: Editor-in-Chief, Neurotherapeutics
  • 2003: Research Award, Dion Johnson Spinal Cord Injury Foundation
  • 2003: Fogan Lecturer, University of Buffalo Medical School, SUNY
  • 2003: Dean's Distinguished Lecture, Georgetown University School of Medicine
  • 2005: Nimmo Visiting Professor, Royal Adelaide Hospital, Australia
  • 2005: Abbie Lecturer, University of Adelaide, Australia
  • 2006: President, American Society for Experimental NeuroTherapeutics (ASENT)
  • 2009: David S. Brown Professorship
  • 2012: Husman Lecture, University of Maryland, College Park

Research Interests:

Dr. Faden's research focuses on mechanisms and modulation of cell death and neuroinflammation after experimental brain or spinal cord injury, including molecular and cell biology, animal modeling, behavior and drug discovery. The program is highly interdisciplinary, utilizing molecular and cellular biology, biochemistry, electrophysiology, pharmacology, behavior, magnetic resonance imaging and spectroscopy, and quantitative histological analysis.

There are 4 major lines of investigation:

  1. examining mechanisms of cell death in CNS injury, using both in vivo and in vitro models with particular emphasis on caspase-dependent versus caspase-independent programmed cell-death;
  2. elucidating the role of metabotropic glutamate receptors (mGluR) in posttraumatic cell death and microglial modulation, and delineating the signal transduction pathways involved;
  3. investigating the role of cell cycle pathways in the pathobiology of traumatic brain and spinal cord injury; and
  4. developing novel neuroprotective treatment strategies, with particular focus on multifunctional targeting.

Active Research Grants:

1998 - 2020

Role: PI
"mGluR5 Inhibits Microglia Activation and Neuronal Cell Death After TBI"
NIH/NINDS Grant Number: 2R01NS0373313-15A1
Award Total: $1,344,240

1998 - 2020

Role: PI
"Role of Cell Cycle Pathways in Traumatic Brain Injury (TBI)"
NIH/NINDS Grant Number: 5R01NS052568
Award Total: $2,357,385

2012 - 2017

Role: MPI, (Dorsey/Faden)
"Spinal Mechanisms Underlying SCI-Induced Pain: Implications for Targeted Therapy."
NIH/NINR Grant Number: 1R01NR013601
Award Total: $3,541,219

2012 - 2017

Role: MPI, (Dorsey/Faden/Greenspan)
"Center for Genomics of Pain "
NIH/NINR Grant Number: 1P30NR014129
Award Total: $2,391,540

2015 - 2020

Role: Co-Investigator (Faden/Lipinski)
"Function and Mechanisms of Autophagy-Lysosomal Pathway in Traumatic Brain Injury"
NIH/NINDS Grant Number: 1R01NS091218
Award Total: $1,678,905

2015 - 2018

Role: PI
"Cell Cycle Pathway Mediates SCI-induced Cognitive Impairment and Depression "
Craig H. Neilsen Foundation Grant Number: 340442
Award Total: $599,999

2016 - 2018

Role: PI
"Hypobaria Exposure Timing After TBI: Targeted Modulation to Improve Outcomes"
Air Force - Expeditionary Medicine, Trauma, and En-route Care (EMTEC) Grant Number: DM150036
Award Total: $500,000

2016 - 2019

Role: MPI (Faden/Fang)
"Biomarkers and Treatment of Hypobaria-Exacerbated TBI "
Air Force Grant Number: 15-017
Award Total: $1,500,000

2020 - Present
Submitted: 2015

Role: PI
"Role of miR-23a/27 an in secondary injury after TBI"
NIH/NINDS R01 Grant Number: PA-13-302
Award Total: $1,687,000


Publications:

  • Stoica BA, Loane DJ, Zhao Z, Kabadi SV, Hanscom M, Byrnes KR, FADEN, A.I. PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury. Journal of Neurotrauma. 2014. 15;31(8):758-72. doi: 10.1089/neu.2013.3194. Epub 2014 Jan 29.
  • Loane DJ, Kumar A, Stoica BA, Cabatbat R, FADEN, A.I. Progressive neurodegeneration after experimental brain trauma; association with chronic microglial activation.  Journal of Neuropathology and Experimental Neurology. 2014;73(1):14-29. doi: 10.1097/NEN.0000000000000021
  • Sun, X., Rai, R., Deschamps, J.R., MacKerell, A.D., FADEN, A.I., Xue, F.  Boc-protected 1-(3-oxocycloalkyl)ureas via a one-step Curtius rearrangement: mechanism and scope.  Tetrahedron Letters.  2014. 22; 55(4):842-844.
  • S.V. Kabadi, FADEN, A.I.  Review: Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation.  International Journal of Molecular Sciences. 2014 Jan 17;15(1):1216-36. doi: 10.3390/ijms15011216.
  • Kabadi SV, Stoica BA, Loane DJ, Luo T, FADEN, A.I. Cell cycle inhibition limits microglial activation, astrocytosis, neuronal loss and neurological dysfunction after experimental traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism. (in press).
  • Sarkar, C., Zhao, Z., Aungst S, Sabirzhanov B, FADEN, A.I., Lipinski MM.  Impaired autophagy flux is associated with neuronal cell death after TBI. Autophagy. 2014 Nov 11:0. [Epub ahead of print].
  • Wu, J., Stoica, BA., Luo, T., Sabirzhanova,  B., Zhao, Z., Guanciale, K., Nayar, S,K, Foss, C.A., Pomper, M.G., FADEN, A.I. Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration and cognitive impairment: involvement of cell cycle activation.  Cell Cycle, 13(15).  [Epub ahead of print]
  • Sabirzhanov, B., Zhao, Z., Stoica, B.A., Loane D.J., Wu, J., Borroto, C., Dorsey, S., and FADEN, A.I. (2014). Down-regulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of pro-apoptotic Bcl-2 proteins.  Journal of Neuroscience; 34 (30):10055-71.
  •  Wu J, Zhao Z, Sabirzhanov B, Stoica BA, Kumar A, Luo T, Skovira J, FADEN, A.I. Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci, 34(33):10989-11006, 2014.
  • Loane, D. J., Stoica, B. A., Tchantchou, F., Kumar, A., Barrett, J. P., Akintola, T., FADEN, A.I. (2014). Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury.  Neurotherapeutics, 2014 Oct;11(4):857-69.
  • Kabadi S.V, FADEN, A.I. (2014). Selective CDK inhibitors: promising candidates for future clinical TBI trials. Neural Regeneration Research 2014 Sep 1;9(17):1578-80.
  • Skopin, M. D., Kabadi, S. V., Viechweg, S. S., Mong, J. A., FADEN, A.I. (2014). Chronic decrease in wakefulness and disruption of sleep-wake behavior after experimental traumatic brain injury. Journal of Neurotrauma 2014 Sep 22. [Epub ahead of print].
  • Lipinski, M. M., Liu, S., Sarkar, C., Dinizo, M., FADEN, A.I., Koh, E., & Wu, J. (2014). Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death.  Cell Death and Disease 2014 Nov 11:0. [Epub ahead of print].
  • FADEN, A.I., Loane DJ. Chronic Neurodegeneration after Traumatic Brain Injury: Alzheimer Disease, Chronic Traumatic Encephalopath or Persistent Neuroinflammation.  Neurotherapeutics. 2015 Jan; 12(1):143-50. doi: 10.1007/s13311-014-0319-5. PMID: 25421001
  • Zhao Z, Sabirzhanov B, Wu J, FADEN, A.I., Stoica BA. Voluntary exercise pre-conditioning activates multiple anti-apoptotic mechanisms and improves recovery after experimental traumatic brain injury. J Neurotrauma. 2015 Sep 1;32(17):1347-60. doi: 10.1089/neu.2014.3739. Epub 2015 May 7. PMID: 25419789
  • FADEN, A.I., Wu J, Stoica BA, Loane DJ. (2015). Progressive inflammatory-mediated neurodegeneration after traumatic brain or spinal cord injury.  British Journal of Pharmacology. 2016 Feb;173(4):681-91.  doi: 10.1111/bph.13179. [Epub ahead of print] PMID: 25939377.
  •  Lakkarajua, S.K., Mbatiaa, H., Hanscomb, M., Zhao, Z., Junfang Wu, J., Stoica, B., MacKerell Jr., A.D., FADEN, A.I., Xue, F. (2015). Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5.  Bioorganic & Medicinal Chemistry Letters. 2015 Jun 1;25(11):2275-9. doi: 10.1016/j.bmcl.2015.04.042. Epub 2015 Apr 20. PMID: 25801156.
  • Stocchetti, N., Taccone, F.S., Citerio, G., Pepe, P.E., Le Roux, P.D. Oddo, M., Polderman, K.H., Stevens, R.D., Barsan, W., Maas, A.I.R., Meyfroidt, G., Bell, M.J., Silbergleit, R., Vespa, P.M., FADEN, A.I., Helbok, R., Tisherman, S., Zanier, E.R., Valenzuela, T., Wendon,  J., Menon, D.K., & Vincent, J.L. (2015). Neuroprotection in acute brain injury: an up-to-date review. Critical Care 19, p. 186. DOI 10.1186/s13054-015-0887-8
  • Sabirzhanov B, Stoica BA, Zhao Z, Loane DJ, Wu J, Dorsey SG, FADEN, A.I. (2015). miR-711 upregulation induces neuronal cell death after traumatic brain injury. Cell Death Differ. 2016 Apr;23(4):654-68. doi: 10.1038/cdd.2015.132. [Epub ahead of print] PMID: 26470728.
  • Lipinski MM, Wu J, FADEN, A.I., Sarkar C. Function and mechanisms of autophagy in brain and spinal cord trauma. Antioxid Redox Signal. 2015 Aug 20;23(6):565-77. doi: 10.1089/ars.2015.6306. Epub 2015 Apr 28. PMID: 25808205.
  • Wu J, Sabirzhanov B, Stoica BA, Lipinski MM, Zhao Z, Zhao S, Ward N, Yang D, FADEN, A.I. Ablation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injury. Cell Cycle. 2015 Dec 2;14(23):3698-712. doi: 10.1080/15384101.2015.1104436. PMID:26505089.
  • Kabadi SV, Stoica BA, Zimmer DB, Afanador L, Duffy KB, Loane DJ, FADEN, A.I. S100B inhibition reduces behavioral and pathological changesin experimental traumatic brain injury. J Cereb Blood Flow Metab. 2015 Dec;35(12):2010-20. doi: 10.1038/jcbfm.2015.165. Epub 2015 Jul 8. PMID: 26154869.
  • He X, Lakkaraju SK, Hanscom M, Zhao Z, Wu J, Stoica B, MacKerell AD Jr, FADEN, A.I., Xue F. Acyl-aminobenzamidazoles: a novel class of neuroprotective agents targeting mGluR5. Bioorg Med Chem. 2015 May 1; 23(9):2211-20. doi: 10.1016/j.bmc.2015.02.054. Epub 2015 Mar 6. PMID: 25801156
  • Loane DJ, Stoica BA, FADEN, A.I. Neuroprotection for traumatic brain injury. Handb Clin Neurol. 2015; 127:343-66. doi: 10.1016/B978-0-444-52892-6.00022-2. PMID: 25702227.
  • Wu J, Zhao Z, Zhu X, Renn CL, Dorsey SG, FADEN, A.I. Cell cycle inhibition limits development and maintenance of neuropathic pain following spinal cord injury. Pain. 2016 Feb; 157(2):488-503. doi: 10.1097/j.pain.0000000000000393. PMID: 26797506
  • Skovira JW, Kabadi SV, Wu J, Zhao Z, DuBose J, Rosenthal R,E Fiskum G, FADEN, A.I. (2016). Simulated Aeromedical Evacuation Exacerbates Experimental Brain Injury. Journal of Neurotrauma. 2016 Jan 7. [Epub ahead of print] PMID: 26593382

Links of Interest:

Dr. Faden's Lab