Dr. Simon is head of the Antigen Purification Facility at the Center for Vaccine Development in the Division of Geographic Medicine. The focus of the work in his lab is on the development of polysaccharide:protein conjugate vaccine strategies for protection against invasive Salmonella bacterial infections. These efforts involve construction of novel glycoconjugates, and assays to determine immunogenicity and vaccine protective efficacy.
Lab Techniques and Equipment:
Protein and polysaccharide purification, conjugation and characterization using a variety of biochemical techniques including SEC, Ion exchange chromatography, and HPLC.