Bookmark and Share

Manjari G. Joshi M.B.B.S.

Academic Title: Associate Professor
Primary Appointment: Medicine
Location: R Adams Cowley Shock Trauma Center, Room T3R51
Phone: (410) 328-3656
Fax: (410) 328-6826

Research Interests:

A. Most of my research has been in collaboration with the trauma surgery and outcome research group at the Shock Trauma Center. For the last 5 years, I have been involved with developing a very elaborate and extensive infection database in the trauma population. This database is focused on the following areas:
     - Demographics and risk factors associated with infections in trauma patients.
     - Incidence and sites of infections in the trauma population. As various critical care, surgical modalities and radiological interventions evolve, there appears to be a change in the incidence, as well as the distribution of various infections.
     - Diagnosis of infections is being constantly evaluated and studied. The new lab tests and radiology studies are changing the diagnostic criteria of infection.
     - Management of infections is being assessed, which includes evaluation of new drugs, curtailing use of unnecessary antibiotics, shorter courses of treatment and novel use of older agents. Incorporating critical care concepts (glycemic control, protein depletion, steroid use, sedation and pneumonia rates etc.) which impact on management of infectious are also being evaluated by this database.
     - Prevention of infections has been an important aspect of the database.
          +Evaluation of the impact of various antibiotics on emergence of multiply resistant bacteria.
          +Risk factors for multiply resistant bacteria are being identified. Based on our observations, we will modify our practices. This would result in safer practices and lower rates of emergence of multiply resistant bacteria.

B. I have been working on several ID projects with 2nd/3rd/4th year medical students.

C. A project evaluating the thoracic infections is being conducted in conjunction with the Cardiothoracic surgery at the Shock trauma Center and a PHD nursing student.

D. New antibiotic trials for skin and soft tissue infections, nosocomial pneumonias and treatment of resistant bacteria are being conducted.

E. Infection Control Protocols to assess the incidence, risk factors, transmission and control of the multiply antibiotic resistant bacteria in trauma patients are being conducted.

F. Projects evaluating safe practices for use of  intravascular devices are being conducted.


Sung J, Bochicchio GV, Joshi M, Bochicchio K, Tracy K, Scalea TM: Admission  hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 59 (1): 80-83, 2005

Sung J, Bochicchio GV, Joshi M, Bochicchio K, Johnson SB, Meyer W, Scalea TM: Persistent  hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 58 (5), 921-924, 2005

Bochicchio GV, Salzano J, Joshi M, Bochicchio K, ScaleaTM: Admission preoperative glucose is predictive of outcome in critically ill trauma patients. Am Surg 71 (2): 171-174, 2005

Bochicchio GV, Joshi M, Bochicchio K, Shih D, Meyer W, Scalea TM: Incidence and impact of risk
factors in critically ill trauma patients. World J Surg 30 (1) :114- 118, 2006

Joshi M, Metzler M, McCarthy M, Olvey S, Kassira W, Cooper A: Comparison of  piparacillin/tazobactam and imipenem/cilastatin, both in combination with tobramycin, administered every 6 hours for treatment of nosocomial pneumonia. Accepted for publication - Respir Med 2006