2001: Ph.D. - Biomedical Engineering, Zhejiang University, P.R.China
Dr. Chen's long-term interest is to use chemical, biological and genetic tools to identify and manipulate signaling pathways that regulate normal hematopoietic stem cell (HSC)/leukemia stem cell (LSC) proliferation/differentiation/apoptosis and to discover new drugs for clinics as well. Related ongoing projects include screening compounds:
- regulating tumor suppressive or oncogenic microRNA function,
- expanding HSC ex vivo,
- inhibiting LSC and leukemia progression by using both in vitro cell culture and our recently developed ex vivo and in vivo mice model.
In addition to the hope of identifying novel target/strategy for leukemia treatment, chemical tools are developed to study how particular microRNA can be regulated in normal HSC and leukemia cells.
Chen X, Chong C. R., Shi L., Yoshimoto T., Sullivan D. J. Jr., Liu J.O. From the Cover: Inhibitors of Plasmodium falciparum Methionine Aminopeptidase 1b Possess Antimalarial Activity. Proceedings of the National Academy of Sciences of U.S.A. 2006;103(39):14548-14553. PMID:16983082
Chong C. R., Chen X, Shi L., Liu J.O. Sullivan D. J. Jr., A clinical drug library screen identifies astemizole as an antimalarial agent. Nature Chemical Biology 2006;2(8):415-416. PMID:16816845
Hu X.V., Chen X, Han K.C., Mildvan A.S., Liu J.O. Kinetic and Mutational Studies of the Number of Interacting Divalent Cations Required by Bacterial and Human Methionine Aminopeptidases. Biochemistry. 2007; 46(44):12833-12843. PMID:17929833
Chen X, Xie S, Kumar N, Shapiro T.A., Liu J.O. Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth in vitro and in vivo. Chemistry and Biology 2009;16(2):193-202. PMID:19246010
Scheibner KA, Teaboldt B, Hauer MC, Chen X, Cherukuri S, Guo Y, Kelley SM, Liu Z, Baer MR, Heimfeld S, Civin CI. MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3theta. PLOS ONE, 2012;7(12):e50895 PMID: 23236401