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Cynthia F Bearer
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Cynthia F Bearer M.D., Ph.D., FAAP

Academic Title: Professor
Primary Appointment: Pediatrics
Administrative Title: Associate Chair For Research, Division Head
Additional Title(s): Mary Gray Cobey Professor of Neonatology
cbearer@peds.umaryland.edu
Location: 110 S. Paca Street, 8-N-165
Phone: (410) 328-6003
Fax: (410) 328-1076

Personal History:

EDUCATION

Degrees

1972: B.A., Smith College, Mathematics
1977: Ph.D., Case Western Reserve University, Biochemistry, Dr. Kenneth Neet
1982: M.D., The Johns Hopkins University, Medicine

Internship and Residency

1982-1983: Intern, Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland
1982-1984: Clinical Fellow in Pediatrics, The Johns Hopkins University School of
Medicine
1983-1984: Resident, Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland

Fellowships

1977-1978: Research Associate, Department of Cell Biology, Baylor College of Medicine, Dr. Lutz Birnbaumer
1978-1979: Postdoctoral Fellow, Department of Pharmacology, University of Texas Medical School at Houston, Dr. Joseph Thompson
1984-1986: Fellow, Joint Program in Neonatology, Harvard Medical School
1986-1987: Fellow, Division of Newborn Medicine, Washington University School of Medicine

Postgraduate Training

1990-1991: Postgraduate training, Occupational and Environmental Medicine, University of California San Francisco
1992: Executive Leadership in Medicine, Levinson Institute, Harvard University

EMPLOYMENT HISTORY

Academic Appointments

1987-1989: Instructor in Pediatrics, Washington University School of Medicine, St. Louis, Missouri
1990-1992: Assistant Adjunct Professor, School of Dentistry, University of California San Francisco, San Francisco, California
1990-1992: Assistant Clinical Professor, Dept. of Medicine, University of California San Francisco, San Francisco, California
1992-1994: Associate Professor, Dept. of Pediatrics, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio
1994-2001: Assistant Professor, Department of Pediatrics & Neurosciences, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio
2001-2008: Associate Professor, Department of Pediatrics & Neurosciences, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio
2003: Award of tenure, Case Western Reserve University
2008: Professor, Department of Pediatrics, Neurosciences and Environmental Health Sciences, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio
2008: Adjunct Professor, Department of Pediatrics, Neurosciences and Environmental Health Sciences, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio
2008: Mary Gray Cobey Professor of Neonatology; Chief, Division of Neonatology, Department of Pediatrics, University of Maryland Hospital for Children, Baltimore, Maryland
2008: Award of tenure, University of Maryland
2008: Chief, Division of Neonatology, University of Maryland Hospital for Children, Baltimore, Maryland

Other Employment

1987-1989: Assistant in Pediatrics, Children's Hospital, St. Louis, Missouri
1987-1989: Assistant in Pediatrics, Barnes Hospital, St. Louis, Missouri
1987-1989: Assistant in Pediatrics, Jewish Hospital, St. Louis, Missouri
1990-1992: Director, Division of Pediatric Environmental Health, Children's Hospital, Oakland Research Institute, Oakland, California
1990-1992: Associate Research Biochemist, Children's Hospital Oakland Research Institute, Oakland, California
1990-1992: Associate Neonatologist, Children's Hospital Oakland, Oakland, California
1992-1994: Director, Division of Neonatology, Tod Children's Hospital, Youngstown, Ohio
1992-1994: Director, Division of Pediatric Environmental Health, Tod Children's Hospital, Youngstown, Ohio
1999-2002: Co-Director, Neonatology Fellowship Training Program, Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio
2002-2008: Director, Neonatology Fellowship Training Program, Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio
2003-2008: Director of Medical Education, Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio
2006-2008: Associate Director, Medical Scientist Training Program, Case Western Reserve University, Cleveland, Ohio

Clinical Speciality:

Practice of Neonatology, including ECMO, ventilator management, pre-op cardiac management, intubation, chest tube placement, neonatal resuscitation, management of extremely premature infants, management of complex congenital malformations


Current Research Grant Support:

2010
Title: Mercury in Donor Blood: A Possible Hazard for Preterm Infants
Position: Principle Investigator, 10% effort
Source: Gerber Foundation
Duration: 2 years, 7/1/10-6/30/12
Total Direct Costs: $100,000

2007
Title: The Role Of Lipid Rafts In Fetal Alcohol Spectrum Disorder.
Position: Principal Investigator, 25% effort
Source: NIH/NIAAA, 1 R01 AA016398-01A1
Duration: 5 years, 5/1/07 – 4/30/12
Total Direct Costs: $1,000,000


Publications:

PUBLICATIONS (Peer Reviewed)

Bearer CF, Neet KE.  Threonine inhibition of the aspartokinase-homoserine dehydrogenase I of E. coli:  Threonine binding studies. Biochemistry 1978; 17:3512-3516.

Bearer CF, Neet KE.  Threonine inhibition of the aspartokinase-homoserine dehydrogenase I of E. coli:  Stopped-flow kinetics and the cooperativity of inhibition of the homoserine dehydrogenase activity. Biochemistry 1978; 17:3517-3522.

Bearer CF, Neet KE.  Threonine inhibition of the aspartokinase-homoserine dehydrogenase I of E. coli:  A slow transient and cooperativity of inhibition of the aspartokinase activity.  Biochemistry 1978; 17:3523-3530

Birnbaumer L, Bearer C, and Iyengar R.  A two-state model of an enzyme with an allosteric regulatory site capable of metabolizing the regulatory ligand. Simplified mathematical treatments of transient and steady state kinetics of an activator and its competitive inhibition as applied to adenylyl cyclases. J Biol Chem 1980; 255:3552-3557.

Bearer CF, Knapp RD, Kaumann AJ, Swartz TL, and Birnbaumer L.  Iodohydroxybenzylpindolol: Preparation, purification, localization  of its iodine to the indole ring, and characterization as a partial agonist. Mol Pharmacol 1980; 17:328-338.

Rosenfeld GC, Strada SJ, Dial EJ, Bearer CF, and Thompson WJ.  Histamine, cyclic nucleotides, and gastric parietal cell secretion. Adv Cyclic Nucleotide Res 1980; 12:255-266.

Bearer CF, Chang K, Rosenfeld GC, and Thompson WJ. Histamine stimulation of rat gastric parietal cell adenyl cyclase: Modulation by guanine nucleotides.  Arch Biochem Biophys 1981; 207:325-336.

Gropper R, Brandt RA, Elias S, Bearer CF, Mayer A, Schwartz AL, and Ciechanover A. The ubiquitin-activating enzyme, El, is required for stress-induced lysosomal degradation of cellular proteins. J Biol Chem 1991; 266:3602-3610.

Bearer CF, Gould S, Emerson R, Kinnunen P, and Cook CS.  Fetal alcohol syndrome and fatty acid ethyl esters. Pediatr Res 1992; 31:492-495.

Warshaver Y, Bearer CF, and Belchis D.  Osteogenesis Imperfecta and Ebstein's Anomaly:  A case report with autopsy findings.  Pediatr Pathol 1992; 12:425-431.

Bearer CF and Phillips R. Pediatric environmental health training: Impact on resident behavior. Am J Dis Child 1992; 147:682-684.

Bearer CF. EMF and infant incubators. Arch Environ Health 1994; 49:352-354.

Bearer CF and Emerson RK. Fetal activity of fatty acid ethyl ester synthases. Research Communications in Alcohol and Substances of Abuse 1995; 16:189-194.

Crump C, Bearer CF, Paschal DC, Rodenbaugh D, and Etzel RA. Mercury exposure in high school chemistry teachers. Arch Environ Contam Toxicol 1996; 31:206-209.

Bearer CF, Emerson RK, Roitman ES, and Shackleton C.  Maternal tobacco smoke exposure and persistent pulmonary hypertension of the newborn. Environ Health Perspect 1997; 105:202-206.

Horowitz RS, Dart RC, Jarvie DR, Bearer CF, and Gupta U.  Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity.  J Toxicol Clin Toxicol 1997; 35:447-51.

Bearer CF, Lee S, Salvator AE, Minnes S, Swick A, Yamashita T and Singer L.  Ethyl linoleate in meconium: A biomarker for prenatal ethanol exposure. Alcohol Clin Exp Res 1999; 23:487-493.

Claudio L, Bearer CF, Wallinga D.  Assessment of the U.S. Environmental Protection Agency methods for identification of hazards to developing organisms. Part I: The reproductive and fertility testing guidelines. Am J Ind Med 1999; 35:543-553.

Claudio L, Bearer CF, Wallinga D.  Assessment of the U.S. Environmental Protection Agency methods for identification of hazards to developing organisms. Part II: The developmental toxicity testing guidelines. Am J Ind Med 1999; 35:554-563.

Bearer CF, Swick AR, O’Riordan MA and Cheng G.  Ethanol inhibits L1 mediated neurite outgrowth in postnatal day 6 cerebellar granule cells.  J Biol Chem 1999; 274:13264-13270.

Bearer CF, O’Riordan MA, and Powers R.  Lead exposure from blood transfusion to premature infants. J Pediatr 2000; 137:549-54.

Bearer CF. The special and unique vulnerability of children to environmental hazards. Neurotoxicology 2000: 21:925-934.

Bearer CF.  L1 Cell Adhesion Molecule Signal Cascades: Targets for Ethanol Developmental Neurotoxicity.  Neurotoxicology 2001;22:625-33.

Nagy LE, Lakshman MR, Casey CA, Bearer CF. Ethanol and membrane protein trafficking: diverse mechanisms of ethanol action. Alcohol Clin Exp Res. 2002 Feb;26(2):287-93.

Bearer CF. Meconium as a biological marker of prenatal exposure. Ambulatory Pediatrics, 2003;3:40-43.

Noland JS, Singer LT, Arendt RE, Minnes S, Short EJ, Bearer CF.  Executive functioning in preschool-age children prenatally exposed to alcohol, cocaine, and marijuana. Alcohol Clin Exp Res. 2003 Apr;27(4):647-56.

Bearer CF, Linsalata N, Yomtovian R, Walsh M, Singer L  Blood transfusions: a hidden source of lead exposure. Lancet 2003;362(9380):332.

Bearer CF, Jacobson JL, Jacobson SW, Barr D, Croxford J, Molteno CD, Viljoen DL, Marais AS, Chiodo LM, Cwik AS. Validation of a new biomarker of fetal exposure to alcohol. J Pediatr 2003 Oct;143(4):463-9. 

Moya J, Bearer CF, Etzel R.  Children’s behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics  2004;113(4 Suppl):996-1006. 

Bearer CF, Santiago LM, O’Riordan MA, Buck K, Lee S, Singer LT.  Fatty acid ethyl esters: Quantitative biomarkers for maternal alcohol consumption. J Pediatr 2005; 146:824-830.

Lanphear B, Bearer CF.  Biomarkers in paediatric research and practice. Archives of Disease in Childhood, 2005;90:594-600.

Noland JS, Singer LT, Short EJ, Minnes S, Arendt RE, Krichner HL, Bearer CF.  Prenatal drug exposure and selective attention in preschoolers.  Neurotoxicology and Teratology 2005;27:429-438.

Bearer CF, Stoler JM, Cook JD.  Biomarkers of  alcohol use in pregnancy.  Alcohol Research and Health, NIAAA publications 2005;28:38-43 (pubs.niaaa.nih.gov/publications/arh28-1/38-43.pdf).

Tang, N, O’Riordan MA, Farkas C, Lemmon V, Bearer CF.  Ethanol inhibits L1 cell adhesion molecule activation of mitogen activated protein kinases.  J Neurochem 2006; 96:1480-90.

Nock ML, O'Riordan MA, Tang N and Bearer CF. L1 cell adhesion molecule found in human CSF varies as a function of age. Experimental Neurology 2006;202:262-265.

Lindsley T, Miller MW, Littner Y, Bearer CF.  Signaling pathways regulating cell motility:  A role in ethanol teratogenicity?  Alcohol Clin Exp Res 2006;30(8):1445-50.

Littner Y, Bearer CF.  Detection of alcohol consumption during pregnancy-Current and future biomarkers. Neurosci Biobehav Rev. 2007;31(2):261-9.

Gubitosi-Klug R, Larimer CG, Bearer CF. L1 cell adhesion molecule is neuroprotective of alcohol induced cell death. Neurotoxicology, 2007;28:457-462.

Littner Y, Cudd TA, O'Riordan MA, Cwik A, Bearer CF.  Elevated Fatty Acid Ethyl Esters in Meconium of Sheep Fetuses Exposed In Utero to Ethanol - A New Animal Model. Pediatr Res. 2008 Feb;63(2):164-8. Epub 2007 Dec 10.

Lai TT, Bearer CF. Iatrogenic environmental hazards in the neonatal intensive care unit. Clin Perinatol. 2008 Mar;35(1):163-81.

Peterson J, Kirchner HL, Xue W, Minnes S, Singer LT, Bearer CF. Fatty acid ethyl esters in meconium are associated with poorer neurodevelopmental outcomes to two years of age. J Pediatr. 2008 Jun;152(6):788-92. Epub 2008 Jan 10.

Bearer CF, Stefanak MA.  Looking Ahead to a Tobacco Free Future (editorial). J Pediatr. 2009 Jan;154(1):4-5. Epub 2008 Nov 5.

Yeaney N, He M, Tang N, Malouf A, O'Riordan M, Lemmon V, Bearer CF. Ethanol inhibits L1 cell adhesion molecule tyrosine phosphorylation and dephosphorylation and activation of pp60src. J Neurochem 2009 Aug;110(3):779-90. Epub 2009 May 3.

Bearer C, Bailey S, Hoek J.  Advancing alcohol biomarkers research. Alcohol Clin Exp Res 2010, Jun;34(6):941-5. Epub 2010 Apr 5.

Gifford AE, Farkas KJ, Jackson LW, Molteno CD, Jacobson JL, Jacobson SW, Bearer CF. Assessment of benefits of a universal screen for maternal alcohol use during pregnancy. Birth Defects Res A Clin Mol Teratol 2010, Oct;88(10):838-46.

Braun JM, Daniels JL, Poole C, Olshan AF, Hornung R, Bernert JT, Xia Y, Bearer C, Barr DB, Lanphear BP.  A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight. Environ Health. 2010 Aug 27;9(1):53.

Gifford AE, Farkas KJ, Jackson LW, Molteno CD, Jacobson JL, Jacobson SW, Bearer CF. Assessment of benefits of a universal screen for maternal alcohol use during pregnancy.  Birth Defects Res A Clin Mol Teratol 2010, Oct;88(10):838-46.

Tang N, Farah B, He M, Fox S, Malouf A, Littner Y, Bearer CF.  Ethanol causes the redistribution of L1 cell adhesion molecule in lipid rafts.  J Neurochem 2011 Sep 2. doi: 10.1111/j.1471-4159.2011.07467.x. [Epub ahead of print]

BOOKS

National Research Council and Institute of Medicine (2004). Children’s Health, the Nation’s Wealth: Assessing and Improving Child Health.  Committee on Evaluation of Children’s Health. NAS/NRC/IOM. Committee to Evaluate Children’s Health. Children’s Health. Board on Children, Youth, and Families, Division of Behavioral and Social Sciences and Education. Washington, DC:  The National Academies Press. 

BOOK CHAPTERS

Bearer CF. Commentator, IN:  Klaus, M. and Fanaroff, A. Care of the High Risk Neonate, 4th edition, WB Saunders Company, Philadelphia, 1993.

Bearer, C.F.  Reviewer, IN:  Klaus, M. Yearbook of Neonatology, Mosby-Yearbook, St. Louis, 1991, 1992, 1993, 1994, 1995, 1996, 1998, 2000, 2001, 2002.

Bearer CF:  Developmental toxicology.  IN: Brooks S (ed)  Comprehensive Textbook of Environmental Medicine, Mosby-Yearbook, St. Louis, 1995.

Bearer CF. Occupational and environmental risks to the fetus.  IN: Martin R, Fanaroff A (eds)  Neonatal-Perinatal Medicine, 6th edition, Mosby-Yearbook, St. Louis, 1997.

Bearer CF.  Contributor, Committee on Environmental Health, American Academy of Pediatrics. Handbook of Pediatric Environmental Health.  Etzel RA, Balk SJ (eds).  American Academy of Pediatrics, Elk Grove Village, IL, 1999.

Bearer CF. Occupational and environmental risks to the fetus.  IN: Martin R, Fanaroff A (eds)  Neonatal-Perinatal Medicine, 7th edition, Mosby-Yearbook, St. Louis, 2001.

Bearer CF.  Developmental neurotoxicity, IN:  Paulson J (ed), Pediatric Clinics of North America, W.B. Saunders Company, Philadelphia, 2001,48:1199-1213.

Bearer CF.  Mechanisms of brain injury, IN:  Bodensteiner JB (ed)  Seminars in Pediatric Neurology, Scher M (guest ed) Fetal and Neonatal Brain Disorders, W.B. Saunders Company, Philadelphia, 2001; 8:100-107.

Gitterman BA, Bearer CF. A developmental approach to pediatric environmental health, IN: Pediatr Clin North Am. 2001 Oct;48(5):1071-83.

Bearer CF.  Contributor, Committee on Environmental Health, American Academy of Pediatrics. Handbook of Pediatric Environmental Health, 2nd edition. Etzel RA, Balk SJ (eds).  American Academy of Pediatrics, Elk Grove Village, IL, 2003.

Bearer CF. Occupational and environmental risks to the fetus.  IN: Martin R, Fanaroff A (eds)  Neonatal-Perinatal Medicine, 8th edition, Mosby-Yearbook, St. Louis, 2005.

Bearer CF. Occupational and environmental risks to the fetus. IN: Martin R, Fanaroff A, Walsh, M (eds) Neonatal-Perinatal Medicine, 9th edition, Mosby-Yearbook, St. Louis, 2010.



Other Publications

Bearer CF.  How are school aged children and adolescents different from adults? 1994, Office of Technology Assessments, Congress of the United States

Bearer CF.  Environmental health hazards:  How children are different from adults.  The Future of Children 1995; 4:11-26.

Bearer CF.  How are children different from adults?  Environ Health Perspect 1995; 103 (Suppl 6):7-12.

American Academy of Pediatrics Committee on Environmental Health.  ETS - A Hazard to Children.  Pediatrics 1997; 99:639-642.

American Academy of  Pediatrics Committee on Environmental Health. (Bearer CF - primary author).  Noise - hazard for the fetus and newborn.  Pediatrics 1997; 100:724-727.

Child Health Workgroup.  Healthy children - toxic environments.  (1997).  U.S. Department of Health and Human Services, Agency for Toxic Substance and Disease Registry, Atlanta, GA.

Bearer CF. Book Review:  Abel EL (ed) “Fetal Alcohol syndrome:  From Mechanism to Prevention.” J Studies Alcohol 1997; 59:350-351.

Bearer CF. Biomarkers in pediatric environmental health: A cross-cutting issue.  Environ Health Perspect 1998; 106 (Suppl 3):813-816.

Landrigan PJ, Carlson JE, Bearer CF, Cranmer JS, Bullard RD, Etzel RA, Groopman J, McLachlan JA, Perera FP, Reigart JR, Robison L, Schell L, and Suk WA.  Children’s health and the environment: A new agenda for prevention research.  Environ Health Perspect 1998; 106 (Suppl 3):787-794.

Bearer CF.  Commentary:  Pediatricians urged to support tougher new food safety law.  AAP News 1999; 15:30.

Bearer CF. Markers to detect drinking during pregnancy.  Alcohol Research & Health. 2001;25(3):210-8.

Bearer CF. Book Review:  Fleming TP (ed) “Cell-Cell Interactions.”  Quarterly Review of Biology, 2003;78(2):222.

Chronicle Guidance Publications, Inc.  Neonatologists, 2004, Moravia, NY.

Needleman HL, Reigart JR, Landrigan P, Sass J, Bearer C. Benefits and risks of pesticide testing on humans. Environ Health Perspect. 2005 Dec;113(12):A804-5. Commentary.

Farah B, Chang C, Bearer C, editors.  Ethical Issues in Children's Environmental Health Research. Mini-monograph. Environ Health Perspect. 114:1603-1629.