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Joseph F. Cheer

Joseph F. Cheer Ph.D.

Academic Title: Associate Professor
Primary Appointment: Anatomy and Neurobiology
Secondary Appointments: Psychiatry
Location: HSF I, 280J
Phone: (410) 706-0112
Fax: (410) 706-2512

Research Interests:

Research in my lab is aimed at understanding the physiological function of the endogenous cannabinoid system with a particular emphasis on normal motivated behaviors as well as its potential therapeutic role in pathological states such as addiction.

Endogenous cannabinoids such as arachidonoylethanolamide (anandamide from the sanskrit word "ananda" meaning bliss) and 2-arachidonoylglycerol (2-AG) and their binding to central cannabinoid receptors (CB1) in the brain and spinal cord make up this recently described signaling system. These molecules have been involved in a wide spectrum of physiological states ranging from reinforcement processing to pain perception and executive function.

Our research employs state-of-the-art electrophysiological (ensemble recordings) and electrochemical (fast-scan cyclic voltammetry) techniques to extract neurobiological correlates of key aspects of behavior in real-time. We have also implemented the use of a microsensor that can simultaneously record extracellular single-unit activity and neurotransmitter release. These techniques are used in conjunction with tools such as systemic drug administration, cerebral microinjection, iontophoresis and optogenetics to examine how endogenous cannabinoids modulate the encoding of motivated behavior.

We are specifically interested in the dopaminergic projection from the ventral tegmental area to the nucleus accumbens. Dopaminergic neurons burst fire in response to rewards and play a key role in the prediction of the availability of reward. We have shown that exogenous cannabinoids potently modulate the activity of dopaminergic neurons, in particular their ability to burst fire and to produce transient increases in dopamine concentration in the nucleus accumbens, suggesting that endogenous cannabinoids are indeed important mediators of reward encoding in behaving animals. Thus, understanding the interactions between endogenous cannabinoid and dopaminergic signaling in the nucleus accumbens during reward-related behavior is likely to yield unprecedented insight on the pathogenesis of disorders of motivation such as addiction.


Lopatina N, MCdannald MA, Styer CV, Sadacca BF, Cheer JF and Schoenbaum G (2015) Lateral orbitofrontal neurons acquire responses to upshifted, downshifted or blocked cues during unblocking. E-Life, 4:e11299

Bagot RC, Parise EM, Maze I, Persaud B, Cachope R, Bolaños CA, Cheer JF, Deisseroth K and Nestler EJ (2015) Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression-like& behavior. Nat. Comm., 6: 7626-7631

Wang H, Treadway T, Covey DP, Cheer JF and Lupica CR (2015) Cocaine-mediated endocannabinoid mobilization in the ventral tegmental area regulates subsecond dopamine release in nucleus accumbens. Cell Rep., 12: 1997-2008

Hernandez G and Cheer JF (2015) To act or not to act: endocannabinoid/dopamine interactions in decision-making. Frontiers. Neurosci, invited review, 9: 1-10

Wenzel JM, Rauscher NA, Cheer JF and Oleson EB. (2015) A role for phasic dopamine release within the nucleus accumbens in encoding aversion: a review of the neurochemical literatureACS Chem. Neurosci.  6: 16-26.

Covey DP, Wenzel JM and Cheer JF. (2014) Cannabinoid modulation of drug reward and the implications of marijuana legalization.  Brain. Res. S0006-8993(14)01618-7 

Kashtelyan V, Lichtenberg NT, Chen ML, Cheer JF and Roesch MR. (2014) Observation of reward delivery to a conspecific modulates dopamine release in ventral striatum. Curr. Biol. 24: 2564-2568.

Covey DP and Cheer JF. (2014) Pick your poison: not all opioids are created equal in the eyes of dopamine (commentary on Vander Weele et al.). Eur. J. Neurosci. 40: 3040

Wenzel JM and Cheer JF. (2014) Endocannabinoid-dependent modulation of phasic dopamine signaling encodes external and internal reward-predictive cues. Front. Psychiatry. 5:118

Schluter EW, Mitz AR, Cheer JF and Averbeck BB. (2014) Real-time dopamine measurement in awake monkeys. PLoS One. 9:e98692

Cachope R and Cheer JF. (2014) Local control of striatal dopamine release. Front. Behav. Neurosci. 8:188

Hernandez G, Oleson EB, Gentry RN, Abbas Z, Bernstein DL, Arvanitogiannis A and Cheer JF. (2014) Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates. Biol. Psychiatry. 75: 487-498.

Oleson EB, Cachope R, Fitoussi A, Tsutsui K, Wu S, Gallegos JA and Cheer JF. (2014) Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. Neuropsychopharmacology. 39: 1441-1452.

Lobo MK, Zaman S, Damez-Werno DM, Koo JW, Bagot RC, DiNieri JA, Nugent A, Finkel E, Chaudhury D, Chandra R, Riberio E, Rabkin J, Mouzon E, Cachope R, Cheer JF, Han MH, Dietz DM, Self DW, Hurd YL, Vialou V and Nestler EJ. (2013) ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J. Neurosci. 33: 18381-18395.

Vinish M, Elnabawi A, Milstein JA, Burke JS, Kallevang JK, Turek KC, Lansink CS, Merchenthaler I, Bailey AM, Kolb B, Cheer JF and Frost DO. (2013) Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function. Int J Neuropsychopharmacol. 16: 1599-5609

Wang B, You ZB, Oleson EB, Cheer JF, Myal S and Wise RA. (2013) Conditioned contribution of peripheral cocaine actions to cocaine reward and cocaine-seeking. Neuropsychopharmacology. 38: 1763-1769

Chandra R, Lenz JD, Gancarz AM, Chaudhury D, Schroeder GL, Han MH, Cheer JF, Dietz DM and Lobo MK. (2013) Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. Front Mol Neurosci. 6:13

Oleson EB and Cheer JF. (2013) On the role of subsecond dopamine release in conditioned avoidance. Front Neurosci. 7: 96

Loewinger GC, Oleson EB and Cheer JF. (2013) Using dopamine research to generate rational cannabinoid drug policy. Drug Testing and Analysis 5: 22-26

Oleson EB, Gentry RN, Chioma VC, Cheer JF. (2012) Subsecond dopamine release in the nucleus accumbens predicts conditioned punishment and its successful avoidance. Journal of Neuroscience, 32: 14804-14808

Lee AM, Oleson EB, Diergaarde L, Cheer JF* and Pattij T*. (2012) Cannabinoids and value-based decision making: Implications for neurodegenerative disorders. Basal Ganglia 2: 131-138. Invited Review, * equal contribution

Oleson EB, Cheer JF. (2012) Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues. Synapse. 66: 984-988

Hernandez G and Cheer JF. (2012)  Effect of CB1 Receptor Blockade on Food-Reinforced Responding and Associated Nucleus AccumbensNeuronal Activity in Rats. Journal of Neuroscience. 32: 11467-11477.

Oleson EB and Cheer JF. (2012) A brain on cannabinoids: the role of dopamine release in reward seeking. Cold Spring Harbor Perspectives in Medicine. 1;2(8)

Loewinger G; Beckert MV; Tejeda H and Cheer JF. (2012) Enduring methamphetamine-induced dopaminergic effects in the nucleus accumbens are exacerbated by reward associated cues and attenuated by CB1 receptor antagonism. Neuropharmacology 62: 2191-2200.

Morra JT; Glick SD and Cheer JF. (2012) Cannabinoid receptors mediate methamphetamine induction of gamma oscillations in the nucleus accumbens. Neuropharmacology 63: 565-574.

Cachope R; Mateo Y; Mathur BN; Irving J; Wang HL; Morales M; Lovinger DM and Cheer JF. (2012) Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing. Cell Reports 2: 33-41.

Oleson EB, Beckert MV, Morra JT, Lansink CS, Cachope R, Abdullah R, Loriaux Al, Schetters D, Pattij T, Roitman MF, Lichtman AH and Cheer JF. (2012) Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum. Neuron 73: 360-373.

Mazei-Robison MS, Koo JW, Lansink CS, Han MH, Robison AJ, Krishnan V, Kim S, Siuta MA, Galli A, Neve RL, Snyder SH, Cheer JF, Russo S and EJ. Nestler. (2011) Morphine-induced changes in dopamine ventral tegmental area neuronal morphology are dependent on mTOR signaling and neuronal activity. Neuron 72: 977-990.

Hernandez G, Bernstein D, Schoenbaum G and Cheer JF. (2011) Contrasting Effects of Lithium Chloride and CB1 Receptor Blockade on Enduring Changes in the Valuation of Reward. Frontiers in Behavioral Neuroscience. 5: 53

Hernandez G and Cheer JF. (2011) Extinction learning of rewards in the rat: is there a role for CB1 receptors? Psychopharmacology (Berl). 217: 189-197

Trujillo-Pisanty I, Hernandez G, Moreau-Debord I, Cossette MP, Conover K, Cheer JF and Shizgal P. (2011) Cannabinoid receptor blockade reduces the opportunity cost at which rats maintain operant performance for rewarding brain stimulation. Journal of Neuroscience. 31: 5426-5435

Morra JT, Glick SD and Cheer JF. (2010) Neural encoding of psychomotor activation in the nucleus accumbens core, but not the shell, requires cannabinoid receptor signaling. Journal of Neuroscience. 30: 5102-5107

Mason R and Cheer JF. (2009) Cannabinoid receptor activation reverses kainate-induced synchronized population burst firing in rat hippocampus. Frontiers in Integrative Neuroscience. 3:13.

Villanueva A; Yilmaz MS; Millington WR; Cutrera RA; Stouffer DG; Parsons LH; Cheer JF* and Feleder C*. (2009) Central Cannabinoid-1 Receptor Antagonist Administration Prevents Endotoxic Hypotension Affecting Norepinephrine Release in the Preoptic Anterior Hypothalamic Area. Shock. 32: 514-620. (* Equal contribution)

Cheer JF; Heien MLAV; Ariansen JL; Aragona BJ, Carelli RM and Wightman RM. (2007) Coordinated accumbal dopamine release and neural activity drive goal-directed behavior. Neuron 54: 237-244

Cheer JF; Wassum KM; Sombers LA; Heien MLAV; Ariansen JL; Aragona BJ; Phillips PEM and Wightman RM (2007) Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. Journal of Neuroscience 27: 791-795

Cheer JF*; Heien MLAV*; Garris PA; Carelli RM and Wightman RM (2005) Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation. Proceedings of the National Academy of Sciences of the United States of America 102: 19150-19155 * These authors contributed equally

Heien MLAV; Khan AS; Ariansen JL; Cheer JF; Phillips PEM; Wassum KM and Wightman RM (2005) Principal component regression resolves dopamine fluctuations in the brain of behaving rats revealed from in vivo voltammetry. Proceedings of the National Academy of Sciences of the United States of America 102: 10023-10028

Cheer JF; Wassum K; Heien MLAV; Phillips PEM and Wightman RM (2004) Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. Journal of Neuroscience 24: 4393-4400

Links of Interest:

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