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Matthew B. Laurens

Matthew B. Laurens M.D., M.P.H.

Academic Title: Associate Professor
Primary Appointment: Pediatrics
Secondary Appointments: Medicine
Location: HSF-I, 480
Phone: 410-706-5328
Phone: 410-706-8695
Fax: 410-706-1204

Personal History:

  • 1992: B.S. Biology, Oglethorpe University, Atlanta Georgia 
  • 1992-1994: Guinea Worm eradication, U.S. Peace Corps, Benin, West Africa 
  • 1994-1995: Project supervisor for hygiene behavior studies, UNICEF, Benin, West Africa 
  • 1996-1997: Instructor in Biostatistics and Epidemiology, Mercer University School of Medicine 
  • 2001: Doctor of Medicine, Mercer Unviersity School of Medicine, Macon, Georgia 
  • 2001-2004: Residency in Pediatrics, Tulane University School of Medicine 
  • 2004-2005: Chief Residency in Pediatrics, Tulane Unviersity School of Medicine 
  • 2005-2008: Fellowship in Pediatric Infectious Diseases and Tropical Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland
  • 2008-2009: Burroughs Wellcome Fund/American Society of Tropical Medicine and Hygiene Postdoctoral Fellowship in Tropical Infectious Diseases

Research Interests:

Dr. Laurens is a pediatric infectious disease specialist, with a primary research interest in malaria and antimalarial immunity. He conducts studies in Baltimore at the CVD and at international sites in Mali and Malawi to evaluate malaria vaccines and therapeutics, to study the interaction of HIV and malaria, and to investigate the acquisition of antimalarial immunity. The broad goal of Dr. Laurens’ research is to illuminate the mechanisms of immunity to malaria with the aim to inform development of malaria vaccines and therapeutics.

Clinical Speciality:

  • Pediatrics
  • Pediatric Infectious Diseases


  1. Hoffman SL, Billingsley PF, James E, Richman A, Loyevsky M, Li T, Chakravarty S, Gunasekera A, Li M, Stafford R, Ahumada A, Epstein JE, Sedegah M, Reyes S, Richie TL, Lyke KE, Edelman R, Laurens MB, Plowe CV, Sim BKL. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Human Vaccines. 2010 Jan 21;6: 97-106.
  2. Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Kone AK, Guindo AB, Traore K, Sissoko M, Diallo DA, Diarra I, Kouriba B, Daou M, Dolo A, Baby M, Sissoko MS, Sagara I, Niangaly A, Traore I, Olotu A, Godeaux O, Leach A, Dubois M, Ballou WR, Cohen J, Thompson D, Dube T, Soisson L, Diggs CL, Takala SL, Lyke KE, House B, Lanar DE, Dutta S, Heppner DG, Plowe CV. Safety and Immunogenicity of an AMA1 Malaria Vaccine in Malian Children: Results of a Phase 1 Randomized Controlled Trial. PLoS One. 2010 Feb 04;5(2):e9041.
  3. Lyke KE, Laurens MB, Adams M, Billingsley PF, Richman A, Loyevsky M, Chakravarty S, Plowe CV, Sim KL, Edelman R, Hoffman SL. Plasmodium falciparum Malaria Challenge by the Bite of Aseptic Anopheles stephensi Mosquitoes: Results of a Randomized Infectivity Trial. PLoS One. 2010 Oct 21;5(10):e13490.
  4. Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Ouattara A, Kone AK, Guindo AB, Traore K, Traore I, Kouriba B, Diallo DA, Diarra I, Daou M, Dolo A, Tolo Y, Sissoko MS, Niangaly A, Sissoko M, Takala-Harrison S, Lyke KE, Wu Y, Blackwelder WC, Godeaux O, Vekemans J, Dubois MC, Ballou WR, Cohen J, Thompson D, Dube T, Soisson L, Diggs CL, House B, Lanar DE, Dutta S, Heppner DG Jr, Plowe CV. A field trial to assess a blood stage malaria vaccine. New England Journal of Medicine. 2011 Sep 14;365(11):1004-13.
  5. Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, Ockenhouse CF, Murphy JR, Komisar J, Thomas N, Loyevsky M, Birkett A, Plowe CV, Loucq C, Edelman R, Richie TL, Seder RA, Hoffman SL. Live Attenuated Malaria Vaccine Designed to Protect through Hepatic CD8+ T Cell Immunity. Science. 2011 Oct 28;334(6055): 475-480.
  6. Laurens MB*, Duncan CJ, Epstein JE, Hill AV, Komisar JL, Lyke KE, Ockenhouse CF, Richie TL, Roestenberg M, Sauerwein RW, Spring MD, Talley AK, Moorthy VS; The Consensus Group on Design of Clinical Trials of Controlled Human Malaria Infection. A consultation on the optimization of controlled human malaria infection by mosquito bite for the evaluation of candidate malaria vaccines. Vaccine. 2012 Aug 3;30(36):5302-5304.
  7. Shaukat AM, Gilliams EA, Kenefic LJ, Laurens MB, Dzinjalamala FK, Nyirenda OM, Thesing PC, Jacob CG, Molyneux ME, Taylor TE, Plowe CV, Laufer MK. Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment. Malaria Journal. 2012 Jun 18;11(1): 207.
  8. Laufer MK, Thesing PC, Dzinjalamala FK, Nyirenda OM, Masonga R, Laurens MB, Stokes-Riner A, Taylor TE, and Plowe CV. A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin, or atovaquone-proguanil to treat malaria. PLoS One. 2012 Aug 17;7(8):e42284.
  9. Boyd MA, Laurens MB, Fiorella PD, Mendley SR. Peritonitis and technique failure caused by Roseomonas mucosa in an adolescent with HIV on continuous cycling peritoneal dialysis. Journal of Clinical Microbiology. 2012 Nov;50(11):3801-4.
  10. Ouattara A, Takala-Harrison S, Thera MA, Coulibaly D, Niangaly A, Saye R, Tolo Y, Dutta S, Heppner DG, Soisson L, Diggs CL, Vekemans J, Cohen J, Blackwelder WC, Dube T, Laurens MB, Doumbo OK, and Plowe CV. Molecular Basis of Allele-Specific Efficacy of a Blood-Stage Malaria Vaccine: Vaccine Development Implications. The Journal of Infectious Diseases. 2013 Feb 1;207(3):511-9.
  11. Coulibaly D, Rebaudet S, Travassos M, Tolo Y, Laurens M, Kone AK, Traore K, Guindo A, Diarra I, Niangaly A, Daou M, Dembele A, Sissoko M, Kouriba B, Dessay N, Gaudart J, Piarroux R, Thera MA, Plowe CV, Doumbo OK. Spatio-temporal analysis of malaria within a transmission season in Bandiagara, Mali. Malaria Journal. 2013 Mar 1;12(1):82.
  12. Laurens MB*, Billingsley P, Richman A, Eappen AG, Adams M, Li T, Chakravarty S, Gunasekera A, Jacob CG, Sim BKL, Edelman R, Plowe CV, Hoffman SL, Lyke KE. Successful Human Infection with P. falciparum using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection. PLoS One. 2013 Jul 16;8(7):e68969.
  13. Travassos MA, Niangaly A, Bailey JA, Ouattara A, Coulibaly D, Laurens MB, Pablo J, Jasinskas A, Nakajima-Sasaki R, Berry AA, Takala-Harrison S, Kouriba B, Rowe JA, Lyke KE, Doumbo OK, Thera MA, Felgner PL, & Plowe CV. Seroreactivity to the PfEMP1 intracellular domain in malaria-exposed children and adults. The Journal of Infectious Diseases. 2013 Nov;208(9):1514-1519.
  14. Seder RA, Chang L, Enama ME, Zephir KL, Sarwar UN, Gordon IL, Holman LA, James ER, Billingsley PF, Gunasekera A, Richman A, Chakravarty S, Manoj A, Velmurugan S, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, Plummer SH, Hendel CS, Novik L, Costner PJM, Mendoza FH, Saunders JG, Nason MC, Richardson JH, Murphy J, Davidson SA, Richie TL, Sedegah M, Sutamihardja MA, Fahle GA, Lyke KE, Laurens MB, Roederer M, Tewari K, Epstein JE, Sim BKL, Ledgerwood JE, Graham BS, Hoffman SL. Protection against malaria by intravenous immunization with a non-replicating sporozoite vaccine. Science. 2013 Sep 20;341(6152):1359-65.
  15. Laurens MB*, Thera MA, Coulibaly D, Ouattara A, Kone AK, Guindo AB, Traore K, Traore I, Kouriba B, Diallo DA, Diarra I, Daou M, Dolo A, Tolo Y, Sissoko MS, Niangaly A, Sissoko M, Takala-Harrison S, Lyke KE, Wu Y, Blackwelder WC, Godeaux O, Vekemans J, Dubois MC, Ballou WR, Cohen J, Dube T, Soisson L, Diggs CL, House B, Bennett JW, Lanar DE, Dutta S, Heppner DG Jr, Plowe CV, Doumbo OK. Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in Malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial. PLoS One. 2013 Nov 18;8(11):e79323.
  16. Murphy SC, Hermsen CC, Douglas AD, Edwards NJ, Petersen I, Fahle GA, Adams M, Berry AA, Billman ZP, Gilbert SC, Laurens MB, Leroy O, Lyke KE, Plowe CV, Seilie AM, Strauss KA, Teelen K, Hill AV, Sauerwein RW. External quality assurance of malaria nucleic Acid testing for clinical trials and eradication surveillance. PLoS One. 2014 May 16;9(5):e97398.
  17. Coulibaly D, Travassos MA, Kone AK, Tolo Y, Laurens MB, Traore K, Diarra I, Niangaly A, Daou M, Dembele A,  Sissoko M, Guindo B, Douyon R, Guindo A, Kouriba B, Sissoko MS, Sagara I, Plowe CV, Doumbo OK, Thera MA. Stable malaria incidence despite scaling up control strategies in a malaria vaccine testing site in Mali. Malaria Journal. 2014 Sep 19;13:374.
  18. Bailey JA, Pablo J, Niangaly A, Travassos MA, Ouattara A, Coulibaly D, Laurens MB, Takala-Harrison S, Lyke KE, Skinner J, Berry AA, Jasinskas A, Nakajima R, Kouriba B, Thera MA, Felgner PA, Doumbo OK, Plowe CV. Seroreactivity to a large panel of field-derived Plasmodium falciparum AMA1 and MSP1 antigen variants reflects seasonal and lifetime acquired antibody responses to malaria. American Journal of Tropical Medicine and Hygiene. 2015 Jan;92(1):9-12. Epub 2014 Oct 6.
  19. Travassos MA, Coulibaly D, Bailey JA, Niangaly A, Adams M, Nyunt MM, Ouattara A, Lyke K, Laurens MB, Pablo J, Jasinkskas A, Nakajima-Sasaki R, Berry AA, Takala-Harrison S, Kone AK, Kouriba B, Rowe A, Doumbo OK, Thera MA, Laufer MK, Felgner PL, Plowe CV. Differential recognition of terminal extracellular Plasmodium falciparum VAR2CSA domains by sera from multigravida, malaria-exposed Malian women. American Journal of Tropical Medicine and Hygiene. Epub 2015 Apr 27.
  20. Travassos MA, Coulibaly D, Laurens MB, Dembélé A, Tolo Y, Koné AK, Traoré K, Niangaly A, Guindo A, Wu Y, Berry AA, Jacobs CG, Harrison ST, Adams M, Shrestha B, Wu AZ, Kouriba B, Lyke KE, Diallo DA, Doumbo OK, Plowe CV, Thera MA. Hemoglobin C trait provides protection from clinical falciparum malaria in Malian children. American Journal of Tropical Medicine and Hygiene. 2015 Jun 3;92(6):1190-4. Epub 2015 May 27.
  21. Ockenhouse CF, Regules J, Tosh D, Cowden J, Kathcart A, Cummings J, Paolino K, Moon J, Komisar J, Kamau E, Oliver T, Chhoeu A, Murphy J, Lyke K, Laurens M, Birkett A, Lee C, Weltzin R, Wille-Reece U, Sedegah M, Hendriks J, Versteege I, Pau MG, Sadoff J, Vanloubbeeck Y, Lievens M, Heerwegh D, Moris P, Guerra Mendoza Y, Jongert E, Cohen J, Voss G, Ballou WR, Vekemans J. Ad35.CS.01 -  RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy Against Sporozoite Challenge in Healthy Malaria-naïve Adults. PLoS One. 2015 Jul 6;10(7):e0131571.
  22. Lyke KE, Laurens MB, Strauss K, Adams M, Billingsley PF, James E, Manoj A, Chakravarty S, Plowe CV, Li ML, Ruben A, Edelman R, Green M, Sim BKL, Hoffman SL. Optimizing Intradermal Administration of Cryopreserved Plasmodium falciparum Sporozoites in Controlled Human Malaria Infection. American Journal of Tropical Medicine and Hygiene. 2015 Sep 28. pii: 15-0341. [Epub ahead of print]
  23. Laurens MB. The Immunologic complexity of growing up with malaria is scientific understanding coming of age? Clinical and Vaccine Immunology. 2015 Dec 16. pii: CVI.00697-15.