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Yu-Ching  Cheng
 

Yu-Ching Cheng Ph.D.

Academic Title: Adjunct Assistant Professor
Primary Appointment: Medicine
ycheng@medicine.umaryland.edu
Location: MSTF, 300C
Phone: 410-706-2913

Personal History:

Dr. Cheng received her PhD degree in Epidemiology with a concentration in Genetic Epidemiology from the Johns Hopkins Bloomberg School of Public Health in 2008. She then came to University of Maryland and completed a two-year post-doctoral fellowship in Epidemiology of Aging under the mentorship of Dr. Braxton Mitchell. She joined the Department of Medicine faculty at the University of Maryland, Baltimore in 2010.

Research Interests:

My research focuses on utilizing a variety of statistical methods to identify genetic and environmental factors that predispose individuals to a variety of complex diseases, including stroke, type 2 diabetes and cardiovascular diseases. I am also interested in discerning the differential genetic effects on diseases among populations of different ethnicity and how environmental exposures may interact with genes to influence the disease risk. Genome-wide association study and admixture mapping are among the common approaches that I use to understand the genetic contributions to complex diseases.


Publications:

  1. Post W, Bielak LF, Ryan KA, Cheng Y-C, Shen H, Rumberger JA, Sheedy PF, Shuldiner AR, Peyser PA, Mitchell BD. Determinants of coronary artery and aortic calcification in the old order amish. Circulation. 2007;115:717-724.
  2. Cheng Y-C, Kao W-HL, Mitchell BD, O'Connell JR, Shen H, McArdle PF, Gibson Q, Ryan KA, Shuldiner AR, Pollin TI. Genome-wide association scan identifies variants near matrix metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum mmp-1 levels / clinical perspective. Circulation: Cardiovascular Genetics. 2009;2:329-337.
  3. Cheng Y-C, Kao W-HL, Mitchell BD, Sharrett AR, Ryan KA, Vogel RA, Shuldiner AR, Pollin TI. Genetic effects on postprandial variations of inflammatory markers in healthy individuals. Obesity. 2010;18:1417-1422.
  4. Cheng Y-C, O'Connell JR, Cole JW, Stine OC, Dueker N, McArdle PF, Sparks MJ, Shen J, Laurie CC, Nelson S, Doheny KF, Ling H, Pugh EW, Brott TG, Brown RD, Meschia JF, Nalls M, Rich SS, Worrall B, Anderson CD, Biffi A, Cortellini L, Furie KL, Rost NS, Rosand J, Manolio TA, Kittner SJ, Mitchell BD. Genome-wide association analysis of ischemic stroke in young adults. G3: Genes, Genomes, Genetics. 2011;1:505-514.
  5. Cheng Y-C, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, Rasheed A, Zeginigg M, Attia J, Baker R, Barlera S, Biffi A, Bookman E, Brott TG, Brown RD Jr., Chen F, Chen WM, Ciusani E, Cole JW, Cortellini L, Danesh J, Doheny K, Ferrucci L, Franzosi MG, Frossard P, Furie KL, Golledge J, Hankey GJ, Hernandez D, Holliday EG, Hsu F-C, Jannes J, Kamal A, Khan MS, Kittner SJ, Koblar SA, Lewis M, Lincz L, Lisa A, Matarin M, Moscato P, Mychaleckyj JC, Parati EA, Parolo S, Pugh E, Rost NS, Schallert M, Schmidt H, Scott RJ, Sturm JW, Yadav S, Zaidi M, GARNET Collaborative Research Group, GENEVA Consortium, Boncoraglio GB, Levi CR, Meschia JF, Rosand J, Sale M, Saleheen D, Schmidt R, Sharma P, Worrall B, Mitchell BD, on behalf of the International Stroke Genetics Consortium. Are myocardial infarction-associated single nucleotide polymorphisms associated with ischemic stroke? Stroke. 2012;43:980-986.
  6. Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M, Jackson CA, Traylor M, Strange A, Su Z, Band G, Syme PD, Malik R, Pera J, Norrving B, Lemmens R, Freeman C, Schanz R, James T, Poole D, Murphy L, Segal H, Cortellini L, Cheng Y-C, Woo D, Nalls MA, Muller-Myhsok B, Meisinger C, Seedorf U, Ross-Adams H, Boonen S, Wloch-Kopec D, Valant V, Slark J, Furie K, Delavaran H, Langford C, Deloukas P, Edkins S, Hunt S, Gray E, Dronov S, Peltonen L, Gretarsdottir S, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Boncoraglio GB, Parati EA, Attia J, Holliday E, Levi C, Franzosi M-G, Goel A, Helgadottir A, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Mathew CG, Palmer CNA, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Worrall BB, Kittner SJ, Mitchell BD, Kissela B, Meschia JF, Thijs V, Lindgren A, Macleod MJ, Slowik A, Walters M, Rosand J, Sharma P, Farrall M, Sudlow CLM, Rothwell PM, Dichgans M, Donnelly P, Markus HS. Genome-wide association study identifies a variant in hdac9 associated with large vessel ischemic stroke. Nat Genet. 2012;44:328-333.
  7. Agrawal A, Freedman ND, Cheng Y-C, Lin P, Shaffer JR, Sun Q, Taylor K, Yaspan B, Cole JW, Cornelis MC, DeSensi RS, Fitzpatrick A, Heiss G, Kang JH, O'Connell J, Bennett S, Bookman E, Bucholz KK, Caporaso N, Crout R, Dick DM, Edenberg HJ, Goate A, Hesselbrock V, Kittner S, Kramer J, Nurnberger JI, Qi L, Rice JP, Schuckit M, van Dam RM, Boerwinkle E, Hu F, Levy S, Marazita M, Mitchell BD, Pasquale LR, Bierut LJ. Measuring alcohol consumption for genomic meta-analyses of alcohol intake: Opportunities and challenges. The American Journal of Clinical Nutrition. 2012;95:539-547.
  8. Cole JW, Stine OC, Liu X, Pratap A, Cheng Y, Tallon LJ, Sadzewicz LK, Dueker N, Wozniak MA, Stern BJ, Meschia JF, Mitchell BD, Kittner SJ, O'Connell JR. Rare variants in ischemic stroke: An exome pilot study. Plos One. 2012;7:e35591.
  9. Holliday EG, Maguire JM, Evans T-J, Koblar SA, Jannes J, Sturm JW, Hankey GJ, Baker R, Golledge J, Parsons MW, Malik R, McEvoy M, Biros E, Lewis MD, Lincz LF, Peel R, Oldmeadow C, Smith W, Moscato P, Barlera S, Bevan S, Bis JC, Boerwinkle E, Boncoraglio GB, Brott TG, Brown RD, Cheng Y-C, Cole JW, Cotlarciuc I, Devan WJ, Fornage M, Furie KL, Gretarsdottir S, Gschwendtner A, Ikram MA, Longstreth WT, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Parati EA, Psaty BM, Sharma P, Stefansson K, Thorleifsson G, Thorsteinsdottir U, Traylor M, Verhaaren BFJ, Wiggins KL, Worrall BB, Sudlow C, Rothwell PM, Farrall M, Dichgans M, Rosand J, Markus HS, Scott RJ, Levi C, Attia J. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet. 2012;44:1147-1151.
  10. Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng Y-C, Fornage M, Ikram MA, Malik R, Bevan S, Thorsteinsdottir U, Nalls MA, Longstreth WT, Wiggins KL, Yadav S, Parati EA, DeStefano AL, Worrall BB, Kittner SJ, Khan MS, Reiner AP, Helgadottir A, Achterberg S, Fernandez-Cadenas I, Abboud S, Schmidt R, Walters M, Chen W-M, Ringelstein EB, O'Donnell M, Ho WK, Pera J, Lemmens R, Norrving B, Higgins P, Benn M, Sale M, Kuhlenbäumer G, Doney ASF, Vicente AM, Delavaran H, Algra A, Davies G, Oliveira SA, Palmer CNA, Deary I, Schmidt H, Pandolfo M, Montaner J, Carty C, de Bakker PIW, Kostulas K, Ferro JM, van Zuydam NR, Valdimarsson E, Nordestgaard BG, Lindgren A, Thijs V, Slowik A, Saleheen D, Paré G, Berger K, Thorleifsson G, Hofman A, Mosley TH, Mitchell BD, Furie K, Clarke R, Levi C, Seshadri S, Gschwendtner A, Boncoraglio GB, Sharma P, Bis JC, Gretarsdottir S, Psaty BM, Rothwell PM, Rosand J, Meschia JF, Stefansson K, Dichgans M, Markus HS. Genetic risk factors for ischaemic stroke and its subtypes (the metastroke collaboration): A meta-analysis of genome-wide association studies. The Lancet Neurology. 2012;11:951-962.
  11. Harriott AM, Dueker N, Cheng YC, Ryan KA, O'Connell JR, Stine OC, McArdle PF, Wozniak MA, Stern BJ, Mitchell BD, Kittner SJ, Cole JW. Polymorphisms in migraine-associated gene, and ischemic stroke risk in a biracial population: The genetics of early onset stroke study. SpringerPlus. 2013;2:46.
  12. Hamedani AG, Cole JW, Cheng Y, Sparks MJ, O'Connell JR, Stine OC, Wozniak MA, Stern BJ, Mitchell BD, Kittner SJ. Factor v leiden and ischemic stroke risk: The genetics of early onset stroke (geos) study. Journal of Stroke and Cerebrovascular Diseases. 2013;22:419-423.
  13. Ryan KA, Cole JW, Saslow K, Mitchell BD, McArdle PF, Sparks MJ, Cheng YC, Kittner SJ. Prevention opportunities for oral contraceptive-associated ischemic stroke. Stroke. 2014;45:893-5.
  14. Prokopenko I, Poon W, Mägi R, Prasad B R, Salehi SA, Almgren P, Osmark P, Bouatia-Naji N, Wierup N, Fall T, Stančáková A, Barker A, Lagou V, Osmond C, Xie W, Lahti J, Jackson AU, Cheng YC, Liu J, O'Connell JR, Blomstedt PA, Fadista J, Alkayyali S, Dayeh T, Ahlqvist E, Taneera J, Lecoeur C, Kumar A, Hansson O, Hansson K, Voight BF, Kang HM, Levy-Marchal C, Vatin V, Palotie A, Syvänen AC, Mari A, Weedon MN, Loos RJ, Ong KK, Nilsson P, Isomaa B, Tuomi T, Wareham NJ, Stumvoll M, Widen E, Lakka TA, Langenberg C, Tönjes A, Rauramaa R, Kuusisto J, Frayling TM, Froguel P, Walker M, Eriksson JG, Ling C, Kovacs P, Ingelsson E, McCarthy MI, Shuldiner AR, Silver KD, Laakso M, Groop L, Lyssenko V. A Central Role for GRB10 in Regulation of Islet Function in Man. PLoS Genet. 2014;10:e1004235.
  15. Cheng YC, Cole JW, Kittner SJ, Mitchell BD. Genetics of Ischemic Stroke in Young Adults. Circulation: Cardiovascular Genetics (Accepted in March 2014).