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Guofeng  Xie

Guofeng Xie M.B.B.S., Ph.D.

Academic Title: Assistant Professor
Primary Appointment: Medicine
Location: UMMC, N3W62
Phone: (410) 328-5780
Fax: (410) 328-8315

Research Interests:

The role of matrix metalloproteinases in mediating muscarinic receptor-dependent intestinal epithelial cell proliferation and colon neoplasia.

Clinical Speciality:

Board certified in Internal Medicine and Gastroenterology


Xie, G., Y. Jia and E. Aamodt. A C. elegans mutant screen based on antibody or histochemical staining. Genetic analysis: Biomolecular Engineering 12:95-100, 1995.

Jia, Y., Xie, G., Aamodt, E. pag 3, a C. elegans gene involved in touch neuron gene expression and coordinated movement. Genetics 142:141-147, 1996.

Jia, Y*., Xie, G*., McDermott, J., Aamodt, E. The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1. *The first two authors contributed equally. Development 124:2063-2073, 1997.

Xie, G., Habbersett, R., Jia, Y., Peterson, S., Lehnert, B., Bradbury, M., D'Anna, J. Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints. Oncogene 16:721-736, 1998.

Sandeep, B., Kurimasa, A., Xie, G., Taya, Y., Araki, R., Abe, M, Crissman, H., Ouyang, H., Li, G., Chen, D. DNA-dependent protein kinase-independent activation of p53 in response to DNA damage. J Biol Chem 274:17139-17143,1999.

Xie, G., Raufman, J-P. Association of protein kinase A with A-kinase anchoring protein150 facilitates pepsinogen secretion from gastric chief cells. Am. J. Physiol. 281:G1051-G1058, 2001.

Khurana, S., Chacon, I., Xie, G., Yamada, M., Wess, J., Raufman, J-P., Kennedy, R. Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-/- mice. Eur. J. Pharmacol. 493:127-132, 2004.

Xie, G., Drachenberg, C., Yamada, M., Wess, J., Raufman, J-P. Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated y M1 and M3 muscarinic receptors. Am. J. Physiol. 289:G521-G529, 2005.

Cheng, K., Xie, G., Raufman, J-P. Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line. Biochem. Pharmacol. 73:1001-1012, 2007.

Hamilton J.P., Xie, G., Raufman, J-P., Hogan, S., Griffin, T.L., Packard, C.A., Chatfield, D.A., Hagey, L.R., Steinbach, J.H., Hofmann, A.F. Human cecal bile acids: concentration and spectrum. Am. J. Physiol. 293(1):G256-63. 2007.

Raufman, J-P., Samimi, R., Shah, N., Khurana, S., Shant, J., Drachenberg, C., Xie, G., Wess, J., Cheng K. Genetic ablation of M3 muscarinic receptors attenuates murine colon neoplasia. Cancer Res. 68(10), May 15, 2008.

Cheng, K., Samimi, R., Xie, G., Shant, J., Drachenberg., Wade, M., Davis, R., Nomikos, G., Raufman, J-P. Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am. J. Physiol. 295(3):G591-7, 2008.

Xie, G., Cheng, K., Shant, J., Raufman, J-P. Acetylcholine-Induced Activation of M3 Muscarinic Receptors Stimulates Robust Matrix Metalloproteinase Gene Expression in Human Colon Cancer Cells. Am. J. Physiol. 2009.