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Rebecca M Brotman
Ph.D., M.P.H.
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| Academic Title:
Assistant Professor |
| Primary Appointment:
Epidemiology and Preventive Medicine |
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rbrotman@som.umaryland.edu |
| Location:
Institute for Genome Sciences, BioPark II,
801 W. Baltimore Street, Room 626 |
| Phone:
(410) 706-6767 |
| Fax:
(410) 706-1482 |
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Personal History
Education
Ph.D., 2007, Johns Hopkins University School of Public Health, Baltimore, MD; Department of Epidemiology; Infectious Diseases Program
M.P.H., 2001, Johns Hopkins University School of Public Health, Baltimore, MD; Concentration: Reproductive Epidemiology
B.A., 1996, Washington University, St. Louis, MO; Major: Political Science, Minor: Biology
Graduate Education and Training:
2007 - 2008: Postdoctoral fellow, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD
2005 - 2007: Predoctoral fellow; Intramural Research Training Award (IRTA), Longitudinal Study of Vaginal Flora, National Institutes of Health, National Institute of Child Health and Human Development, Division of Epidemiology, Statistics and Prevention Research (DESPR), Rockville, MD
Research Interests
My research interests span a broad range of topics in Reproductive and Infectious Diseases Epidemiology. I am currently developing a research program in the epidemiology of bacterial vaginosis (BV). BV is a disruption of the vaginal microbiota which is associated with adverse obstetric and gynecologic outcomes. National surveys indicate the prevalence of BV among U.S. women is 29%, and yet, despite considerable effort, the etiology of BV remains unknown. We recently completed a study which suggested that vaginal douching cessation may reduce the risk for BV. Specimens collected in the study also revealed surprising observations on the fluctuation of BV and are now the focus of my current research. Future work will involve studies of the pathophysiology of BV, including the various behavioral and biological factors associated with the acquisition, remission and recurrence of BV.
Grants and Contracts:
Maryland Cigarette Restitution Fund Program: Effects of smoking on women's reproductive health
Role: Co-investigator
The study will investigate the hypothesis that smoking induces changes in the vaginal microbiota that lead to an increase in risk for bacterial vaginosis (BV). The study will compare the structure (species composition and rank abundance) of vaginal microbial communities between smokers and non-smokers.
Publications
Stekler J, Bachmann L, Brotman RM, Erbelding EJ, Lloyd LV, Rietmeijer CA, Handsfield HH, Holmes KK, Golden MR: Concurrent sexually transmitted infections (STIs) in sex partners of patients with selected STIs: implications for patient-delivered partner therapy. Clin Infect Dis 40:787-793, 2005.
Klebanoff MA, Andrews WW, Yu KF, Brotman RM, Nansel TR, Zhang J, Cliver SP, Schwebke JR: A pilot study of vaginal flora changes with randomization to cessation of douching. Sex Transm Dis 33:610-613, 2006.
Brotman RM, Erbelding EJ, Jamshidi RM, Klebanoff MA, Zenilman JM, Ghanem KG: Findings Associated with Recurrence of Bacterial Vaginosis among Adolescents Attending Sexually Transmitted Diseases Clinics. Journal of pediatric and adolescent gynecology 20:225-231, 2007.
Brotman RM, Klebanoff MA, Nansel T, Zhang J, Schwebke JR, Yu KF, Zenilman JM, Andrews WW: Why Do Women Douche? A Longitudinal Study with Two Analytic Approaches. Ann Epidemiol 18:65-73, 2008.
Brotman RM, Ghanem KG, Klebanoff MA, Taha TE, Scharfstein DO, Zenilman JM. The Effect of Vaginal Douching Cessation on Bacterial Vaginosis: A Pilot Study. Am. J. Obstet. Gynecol. 2008 Jun;198(6):628.e1-7
Brotman RM, Ravel J. [Invited Commentary] Ready or not: The molecular diagnosis of bacterial vaginosis. Clin Infect Dis. 2008 Jul 1;47(1):44-6.
Brotman RM, Klebanoff MA, Nansel TR, Andrews WW, Schwebke JR, Zhang J, Yu KF, Zenilman JM, Scharfstein DO. A longitudinal study of vaginal douching and bacterial vaginosis -- A marginal structural modeling analysis. Am J Epidemiol. 2008 Jul 15;168(2):188-96.
Rifkin SB, Smith MR, Brotman RM, Gindi RM, Erbelding, EJ. Hormonal contraception and risk of bacterial vaginosis diagnosis in an observational study of women attending STD clinics in Baltimore, MD. Contraception 80:63-67, 2009. PMID: 19501217
Brotman RM, Melendez JH, Galai N, Zenilman JM. Effect of Menses on Clearance of Y-Chromosome in Vaginal Fluid: Implications for a Biomarker of Recent Sexual Activity, Sex Transm Dis, in press.
Klebanoff MA, Nansel TR, Brotman RM, Zhang J, Yu K, Schwebke JR, Andrews WW. Personal hygienic behaviors and bacterial vaginosis, Sex Transm Dis, in press.
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