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W. Florian Fricke
Ph.D.
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| Academic Title:
Research Associate |
| Primary Appointment:
Microbiology and Immunology |
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wffricke@som.umaryland.edu |
| Location:
HSF-II,
S-431 |
| Phone:
(410) 706-7983 |
| Fax:
(410) 706-6785 |
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Personal History
* Dipl., 2000, Biology, University of Goettingen, Germany
* Ph.D., 2001-05, Microbial Genomics, University of Goettingen, Germany (Advisor: Dr. Gerhard Gottschalk)
* Post-doctoral fellow, 2005-06, Goettingen Genomics Laboratory, Germany
* Post-doctoral fellow, 2006-07, The Institute for Genomic Research (TIGR), Rockville, Maryland (Mentor: Dr. Jacques Ravel)
Research Interests
My research focuses on comparative microbial genome analysis as a means to understand the evolution and dissemination of virulence and antimicrobial resistance determinants from environmental and agricultural isolates (non-typhoidal Salmonella, E. coli, Bacilli) as well as their interaction with the human microbiome.
Publications
W.F. Fricke, B. Kusian and B. Bowien (2008). The genome organization of Ralstonia eutropha strain H16 and related species of the Burkholderiaceae. Journal of Molecular Microbiology and Biotechnology, in press.
D.A. Rasko, M.J. Rosovitz, G.S. Myers, E.F. Mongodin, W.F. Fricke, P. Gajer, J. Crabtree, V. Sperandio and J. Ravel (2008). The pan-genome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates. Journal of Bacteriology 190(20):6881-93.
W.F. Fricke, M.S. Wright, A.H. Lindell, D.M. Harkins, C. Baker-Austin, J. Ravel and R. Stepanauskas (2008). Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5. Journal of Bacteriology 190(20):6779-94.
H. Seedorf, W.F. Fricke, B. Veith, H. Bruggemann, H. Liesegang, A. Strittmatter, M. Miethke, W. Buckel, J. Hinderberger, F. Li, C. Hagemeier, R.K. Thauer and G. Gottschalk (2008). The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features. Proceedings of the National Academy of Sciences USA 105(6):2128-33.
T.J. Welch, W.F. Fricke, P.F. McDermott, D.G. White, M.L. Rosso, D.A. Rasko, M.K. Mammel, M. Eppinger, M.J. Rosovitz, D. Wagner, L. Rahalison, J.E. Leclerc, J.M. Hinshaw, L.E. Lindler, T.A. Cebula, E. Carniel and J. Ravel (2007). Multiple antimicrobial resistance in plague: an emerging public health risk. PLoS ONE 2(3):e309.
A. Pohlmann*, W.F. Fricke*, F. Reinecke*, B. Kusian, H. Liesegang, R. Cramm, T. Eitinger, C. Ewering, M. Potter, E. Schwartz, A. Strittmatter, I. Voss, G. Gottschalk, A. Steinbuchel, B. Friedrich and B. Bowien (2006). Genome sequence of the bioplastic-producing "Knallgas" bacterium Ralstonia eutropha H16. Nature Biotechnology 24(10):1257-62. (*contributed equally)
W.F. Fricke, H. Seedorf, A. Henne, M. Kruer, H. Liesegang, R. Hedderich, G. Gottschalk and R.K. Thauer (2006). The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesis. Journal of Bacteriology 188(2):642-58.
S. Waack, O. Keller, R. Asper, T. Brodag, C. Damm, W.F. Fricke, K. Surovcik, P. Meinicke and R. Merkl (2006). Score-based prediction of genomic islands in prokaryotic genomes using hidden Markov models. BMC Bioinformatics 7:142.
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