Jacques Ravel
 

Jacques Ravel Ph.D.
Academic Title: Associate Professor
Primary Appointment: Microbiology and Immunology
Additional Title(s): Associate Professor, Institute for Genome Sciences
jravel@som.umaryland.edu
Location: HSF-II S-451
Phone: (410) 706-5674

Personal History

  • B.Sc., 1990, Biology and Chemistry, University of Nancy I, France
  • M.Sc., 1992, Microbiology, University of Nancy I, France
  • Ph.D., 1994-99, Microbial Ecology, University of Maryland at College Park (Dr. Russell Hill, advisor)
  • Post-doctoral fellow, 1999-2002, The Johns Hopkins University, Chemistry Department (Dr. Craig Townsend)
  • Assistant Investigator, 2002-2007, The Institute for Genomic Research (TIGR), Rockville, MD

Research Interests

My research focuses on the application of microbial genomics to three main topics: Exploring the human microbiome: ecology and metagenomics, Microbial genome sequence comparative analyses: the making of a genome with a special emphasis on human microbial pathogens, including Bacillus anthracis, Bacillus cereus, Yersinia pestis, Yersinia pseudotuberculosis, Enteropathogenic Escherichia coli (including E. coli 0157:H7 from contaminated food), Shigella spp., and Salmonella sp.; and Chemical genomics: from genes to structure with a emhphasis on the development of novel bioinformatics tools for the analysis of the secondary metabolic potential of microbes. These are being integrated into 2METDB: a knowledge-based predictive tools for secondary metabolism.

My research activities are funded through grants from NIH, NSF, USDA and DoJ.

Publications

M. Eppinger, MJ Rosovitz, W.F. Fricke, D.A. Rask, G. Korkorina, C. Fayolle, L.E. Lindler, E. Carniel, J. Ravel. 2007. Genome Sequence of Y. pseudotuberculosis IP31758, the causative agent of Far East Scarlet Like Fever (FESLF): Linking Genomic Plasticity to Pathogenicity. 2007. PLoS Genetics. 3(8): e142.

T.J. Welch, W.F. Fricke, M.-L. Rosso, D.A. Rasko, M.K. Mammel, M. Eppinger, MJ Rosovitz, D.G. White, P.F. McDermott, D. Wagner, L. Rahalison, J.E. LeClerc, J.M. Hinshaw, L.E. Lindler, T.A. Cebula, E. Carniel and J. Ravel. 2007. Multiple antimicrobial resistance in Plague: an emerging risk. PLoS ONE. 2(3): e309.

Rasko DA, Rosovitz MJ, Okstad OA, Fouts DE, Jiang L, Cer RZ, Kolsto AB, Gill SR, Ravel J. 2007. Complete sequence analysis of novel plasmids from emetic and periodontal Bacillus cereus isolates reveals a common evolutionary history among the B. cereus group plasmids including B. anthracis pXO1. Journal of Bacteriology 189:52-64.

R. Auerbach, A. Tuanyok, W. Probert, L. Kenefic, A. Vogler, D. Bruce, C. Munk, T. Brettin, M. Eppinger, J. Ravel, D. Wagner and P.l Keim. 2007. Yersinia pestis Evolution on a Small Timescale: Comparison of Whole Genome Sequences from North America. PLoS ONE. 2(8): e770.

K. Lee, D.N. Barker, J. Ravel, R. Auerbach, D. Wagner, P. Keim and J.G. Leid. 2007. Phenotypic and functional characterization of Bacillus anthracis biofilms. Microbiology. 153(6):1693-701.

M.N. Van Ert, W.R. Easterday, L.Y. Huynh, M.E. Hugh-Jones, J. Ravel, S.R. Zanecki, T. Pearson, T.S. Simonson, J.M. U'ren, S.M. Kachur, R.R. Leadem, S.D. Rhoton, G. Zinser, J. Farlow, P.R. Coker, K.L. Smith, B. Wang, L.J. Kenefic, C.M. Fraser, D.M. Wagner, and P. Keim. 2007. Global Genetic Population Structure of Bacillus anthracis. PLoS ONE. 2(5):e461.

Van Ert MN, Easterday WR, Simonson TS, U'ren JM, Pearson T, Kenefic LJ, Busch JD, Huynh LY, Dukerich M, Trim CB, Beaudry J, Welty-Bernard A, Read T, Fraser CM, Ravel J, Keim P. 2007. Strain-specific single nucleotide polymorphism assays for the Bacillus anthracis Ames strain. Journal of Clinical Microbiology. 45(1):47-53.

Donia M., Hathaway B.J., Sudek S., Haygood M.G., Rosovitz M.J., Ravel J., and Schmidt E.W. 2006. Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nature Chemical Biology. 2(12):729-35.

Paulsen I.T., Press C., Ravel J., Kobayashi D.Y., Myers G.S.A., Mavrodi D.V., DeBoy R.T., Seshadri R., Ren Q., Madupu R., Dodson R.J., Durkin A.S., Brinkac L.M., Daugherty S.C., Sullivan S.A., Rosovitz M.J., Gwinn M.L., Zhou L., Nelson W.C., Weidman J., Watkins K., Tran K., Khouri H., Pierson E.A., Pierson L.S. III, Thomashow L.S., and Loper J.E. 2006. Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5: insights into the biological control of plant disease. Nature Biotechnology. 23:873-878.

Schmidt E.W., Nelson J.T., Rasko D,A., Sudek S., Eisen, J.A., Haygood, M.G. and Ravel J. 2005. Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proceedings of the National Academy of Sciences USA. 102(20):7315-7320.

Rasko D.A., Myers G.S., Ravel J. 2005. Visualization of comparative genomic analyses by BLAST score ratio. BMC Bioinformatics. 6(1):2.

Ravel J. and C.M. Fraser. 2005. Genomics at the genus scale. Trends in Microbiology. 13(3)94-96.

T. Pearson, J. Busch, J. Ravel, T.D. Read, S. Rhoton, J. U'ren, T. Simonson, S. Kachur, R. Leadem, M. Cardon, M. Van Ert, L. Huynh, C.M. Fraser and P. Keim. 2004. Phylogenetic discovery bias in Bacillus anthracis using single nucleotide polymorphisms from whole genome sequencing. Proceedings of the National Academy of Sciences USA. 101(37):13536-13541.

Hoffmaster, A.R., J. Ravel, D.A. Rasko, G.D. Chapman, M. Chute C.K. Marston, B.K. De, C.T. Sachhi, C. Fitzgerald, L.W. Mayer, M.C.J. Maiden, F.G. Priest, M. Barker, Lingxia Jiang, R.Z. Cer, J. Rilstone, S.N. Peterson, R.S. Weyant, R. Galloway, T.D. Read, T. Popovic and C.M. Fraser. 2004. Discovery of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax: public health challenges in the age of bioterrorism. Proceedings of the National Academy of Sciences USA. 101(22):8449:8454.




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