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Violeta  Rus
 

Violeta Rus M.D., Ph.D.

Academic Title: Associate Professor
Primary Appointment: Medicine
VRUS@UMARYLAND.EDU
Location: MSTF Room 8-34
Phone: (410) 706-8456
Fax: (410) 706-0231
Lab: (410) 706-3205

Research Interests:

Dr Rus’ lab objective is to define the mechanisms that regulate (auto) ab mediated responses in lupus with the goal of developing immune based therapy which can modulate these responses. Research is performed in both the human system and in the well characterized chronic graft-versus –host disease model of lupus like disease. Currrent studies are aimed at defining the in vivo role of TNF Related Apoptosis Inducing Ligand (TRAIL) in the development of the (auto)ab mediated immune response. The focus of the research is on the role of TRAIL in (auto) atg specific clonal expansion, the persistence of the autoimmune response and on the in vivo manipulation of TRAIL-TRAIL R system as a potential therapeutic tool in lupus.

Publications:

Via CS, Shustov A, Rus V, Lang T, Nguyen P, Finkelman FD. In vivo neutralization of TNF-alpha promotes humoral autoimmunity by preventing the induction of CTL. J Immunol 2001;167:6821-6

Rus V, Atamas SP, Shustova V, Luzina IG, Selaru F, Magder LS, Via CS. Expression of cytokine- and chemokine-related genes in peripheral blood mononuclear cells from lupus patients by cDNA array. Clin Immunol 2002; 102:283-90

Keiser RE, Rus V,Todd CW, Kalappa N, Flores R.  Evidence for Aerobic insufficiency in  Women with Systemic Lupus Erythematosus .Arthritis Rheum ; Arthritis Care & Research 2003, 49:16-22   

Niculescu, F., Nguyen P., Niculescu F., Rus H., Rus V. and Via, C.S. Signal transduction pathways activated in acute and chronic graft versus host disease (GVHD) in the parent-into-F1 mouse model (P->F1). Arthritis Rheum. 2003, 48:1071-1079

Niculescu T, Weerth S, Soane L, Niculescu F, Rus V, Raine CS, Shin ML, Rus H. Effects
of membrane attack complex of complement on apoptosis in experimental autoimmune    encephalomyelitis. Ann N Y Acad Sci. 2003 Dec;1010:530-3.

Rus V, Chen H, Zernetkina V, Magder LS, Mathai S, Hochberg MC, Via CS. Gene expression profiling in peripheral blood mononuclear cells from lupus patients with active and inactive disease. Clin Immunol. 2004,112, 231-234  

Rus V, Zernetkina V, Puliaev R, Cudrici C,  Mathai S, Via CS. Increased Expression and Release of Functional Tumor Necrosis Factor–Related Apoptosis- Inducing Ligand   (TRAIL) by T Cells from Lupus Patients with Active Disease.  Clin Immunol 2005, 117, 48-56.

Krishnan Sandeep, Kiang JG, Fisher CU, Nambiar MP, Nguyen HT, Kyttaris VC, Chowdhury B, Rus V, Tsokos GC. Increased Caspase-e Expression and Activity    Contributes to Reduced CD3¿ Expression in Systemic Lupus Erythematosus T cells. J Immunol. 2005;175(5):3417-23