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Personal History
Education
- Master of Science (1994-1996): Botany/Biochemistry -Dr. B.A. Marathawada University Aurangabad, Maharashtra, India
- Doctor of Philosophy (1998- 2003): Biotechnology- National Chemical laboratory (CSIR), University of Pune, Maharashtra, India
Post Doctoral Training
- April 2003-June 2007: Postdoctoral Research Associate School of Pharmacy Texas Tech University, Amarillo, TX USA
- July 2007 to June 2012: Postdoctoral fellow Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore, MD USA
Research Associate
- July 2012 to Present: Research Associate (Faculty) Department of Pharmacology and Experimental Therapeutics, University of Maryland, Baltimore
Research Interests
Currently I am working on Nrf2 and INrf2 signalling with following areas:
- To study the role of Nrf2 and INrf2 (Keap1) in the modulation of cell signalling in cancer.
- To study the Nrf2/INrf2 signalling in the tissue specific conditional knockout mouse model.
- To study the role of Nrf2/INrf2 in cancer prevention.
Publications
Niture, S. K. and Jaiswal A. K. (2012) Nrf2 up-regulates anti-apoptotic protein Bcl-2 and prevents cellular apoptosis J. Biol. Chemistry, 287(13) 9873-9886
Kaspar, J.W. Niture, S. K. and Jaiswal, A. K. (2012) INrf2 (Keap1) Anti-oxidant induced INrf2(Keap1) Tyrosine85 phosphorylation controls the nuclear export and degradation of the INrf2/Cul3-Rbx1 complex to allow normal Nrf2 activation/repression J. Cell Science, 125,(4)1027-1038.
Niture, S. K. and Jaiswal A. K. (2011) Inhibitor of Nrf2 (INrf2 or Keap1) degrades Bcl-xL via Phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chemistry, 286 (52) 44542-44556
Niture, S. K., Jain, A. K., Shelton, P.M., and Jaiswal, A.K. (2011) Src subfamily kinases regulate nuclear export and degradation of Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression. J. Biol. Chemistry, 286(33):28821-28832
Niture, S. K. and Jaiswal A. K. (2011) INrf2 (keap1) targets Bcl-2 degradation and controls cellular apoptosis, Cell Death & Differentiation, 18(3):439-451
Niture, S. K. and Jaiswal A. K. (2010) Hsp90 interaction with INrf2 (Keap1) mediates stress-induced Nrf2 activation J. Biol. Chemistry, 285(47):36865-36875
Niture, S.K., Kaspar, J. W., Shen, J., and Jaiswal, A.K. (2010) Nrf2 Signalling and Cell Survival. Toxicol. Appl. Phammacol. 244 (1): 37-42
Niture, S. K., Jain A. K. and Jaiswal A. K. (2009) Antioxidant-induced modification of INrf2C151 and PKC-delta-mediated phosphorylation of Nrf2S40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. J. Cell Science, 122 (24): 4452-4464.
Niture, S. K. and Jaiswal A.K (2009) Prothymosin-alpha mediates nuclear import of INrf2/Cul3-Rbx1 complex to degrade nuclear Nrf2, J. Biol. Chemistry, 284 (20):13856-13868.
Kasper J.W., Niture, S. K. and Jaiswal, A.K (2009) Nrf2/INrf2 (keap1) signalling in oxidative stress, Free Radical Biol. & Medicine 47(9) 1304-1309.
Velu, C.S., Niture, S. K., Doneanu, C., Pattabiraman N. and Srivenugopal, K.S. (2007) Oxidative stress inhibits human p53 by glutathionylation of cysteines in the proximal DNA-binding domain and disruption of dimerization, Biochemistry 46 (26): 7765-7780
Niture, S. K., Velu C. S., Smith, Q., Bhat G. J. & Srivenugopal K.S. (2007) Increased expression of the MGMT repair protein by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines, Carcinogenesis 28(2):378-389.
Niture, S. K., Rao U. S. and Srivenugopal, K.S. (2006) Chemopreventative strategies targeting the MGMT repair protein: Augmented expression in human lymphocytes and tumor cells by ethanolic and aqueous extracts of several Indian medicinal plants. International J. Oncology 29(5):1269-1278.
Niture, S.K., Velu, C.S., Bailey, N.I. & Srivenugopal, K.S. (2005) S-thiolation mimicry: quantitative and kinetic analyses of redox status of protein cysteines by glutathione-affinity chromatography. Arch. Biochem. Biophys. 444(2): 174-184.
Niture, S.K., Doneanu, C., Velu, C.S., Bailey, N.I. & Srivenugopal, K.S. (2005) Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry, Biochem. Biophys. Res. Commun. 337(4):1176-1184.
Niture, S. K. (2008) Comparative biochemical and structural characterizations of fungal polygalacturonases, Biologia: Cellu. & Mol. Biol. 63(1): 1-19.
Niture, S. K., Kumar, A. R., Parab, P. B. and Pant, A. (2008) Inactivation of polygalacturonase and pectate lyase produced by pH tolerant fungus Fusarium moniliforme NCIM 1276 in a liquid medium and in host tissue, Microbiol. Res. 163 (1): 51-62.
Niture, S. K., & Pant, A. (2007) Production of cell-wall degrading enzymes by a pH tolerant estuarine isolate Fusarium moniliforme NCIM1276 in different culture conditions, Word J. Microbiol. Biotechnol. 23 (8): 1169-1177.
Niture, S. K., Kumar, A., and Pant, A. (2006) Role of glucose in production and repression of polygalacturonase and petate lyase from phytopathogenic fungus Fusarium moniliforme NCIM 1276, Word J. Microbiol. Biotechnol. 22(9): 893-899.
Niture, S. K. & Pant, A. (2004) Purification and biochemical characterization of polygalacturonase II produced in semi-solid medium by a strain of Fusarium moniliforme, Microbiol. Res. 159(3): 305-314.
Niture, S. K., Pant, A. & Kumar, A. R. (2001) Active site characterization of the single endo-polygalacturonase produced by Fusarium moniliforme NCIM 1276. Eur. J. Biochem. 268(3): 832-840.
Niture, S. K. and Jaiswal A.K (2010), Antioxidant induction of gene expression. Comprehensive Toxicology 2: 523-528.
Oral and Poster Presentations:
Approximately 25 abstracts at National and International Scientific Meetings.