701 W. Pratt St.,
1975: B.S. China Pharmaceutical University, Nanjing, P.R. China.
1987: Ph.D. "Mario Negri" Institute, Milan, Italy
The research projects are mainly focused on the mechanism of kynurenic acid, a broad spectrum antagonist at excitatory amino acid receptors and particularly at the strychnine-insensitive glycine site of NMDA receptors, involved in physiological modulation of the neurotransmitters and in the etiology of neurodegeneration, drug addiction, and epilepsy. Various animal models, mostly in vivo in freely moving animals, are used to monitor the endogenous levels of kynurenic acid by brain microdialysis, the electroencephalographic pattern and the histological changes with different pharmacological treatment. Studies on kynurenate-related agents which influence the kynurenine pathway and are shown potential effects of neuroprotection and anticonvulsion are also conducted.
Wu, Hui-Qiu and R. Schwarcz (1998). Focal mcroinjection of (g-acetylenic acid into the rat entorhinal cortex: behavioral and electroencephalographic abnormalities and preferential neuronal loss in layer III. Exp. Neurol. 153: 203-213.
Rassoulpour, A., H.-Q. Wu, B. Poeggeler and R. Schwarcz (1998). Systemic d-amphetamine administration causes a reduction of kynurenic acid levels in rat brain. Brain Res. 802:111-118.
Poeggleler, B., A. Rassoulpour. P. Guidetti, H.-Q. Wu and R. Schwarcz (1998). Dopaminergic control of kynurenate levels and N-methyl-D-aspartate toxicity in the developing rat striatum. Dev. Neurosci. 20:146-153.
Schwarcz R, H.-Q. Wu, A. Rassoulpour,C.A. Tamminga, D. R. Medoff and R.C. Roberts (1997). Posmortem determination of kynurenine and kynurenic acid levels in the brains of schzophrenic patients. Schzophrenia Res. 24:36.
Wu, H.-Q. and F. Salituro, R, Schwarcz (1997). Enzyme-catalyzed production of the neuroprotective NMDA receptor antagonist 7-chlorokynurenic acid in the rat brain in vivo. Eur. J. Pharmacol. 319:13-20.
Speciale, C., H.-Q. Wu, M. Cini, M. Marconi, M. Varasi and R. Schwarcz (1996). (R,S)-3,4-dichlorobenzoylalanine (FCE28833A) causes a large and persistent increase in brain kynurenic acid levels in rats. Eur. J. Pharmacol. 315:263-267.
Hokari, M., H.-Q. Wu, R. Schwarcz, and Q. R. Smith (1996). Facilitated brain uptake of 4-chlorokynurenine as a prodrug for 7-chlorokynurenic acid. NeuroReport. 8: 15-18.
Wu, H.-Q. and R, Schwarcz (1996). Seizure-related elevation of extracellular kynurenic acid in rat hippocampus. Brain Res Bull. 39:155-162.
Wu, H.-Q., A. Monno, R. Schwarcz and A Vezzani (1995). Electrical kindling is associated with a lasting increase in the extracellular levels of kynurenic acid in the rat hippocampus. Neusci. Lett. 198:91-94.
Wu, H.-Q., U Ungestedt and R. Schwarcz (1995). L-a-Aminoadipic acid reduces kynurenic acid production in hippocampus by microdialysis in freely moving rats. Eur. J. Pharmacol. 281:55-61.
Wu, H.-Q., R. Schwarcz and P. Shepard (1994). Excitatory amino acid-induced excitation of dopamine-containing neurons in the rat substantia nigra: modulation by kynurenic acid. Synapse 16:219-230.
Walsh, J., H.-Q. Wu, U. Ungestedt and R. Schwarcz (1994). 4-Chloro-3-hydroxyanthranilate inhibits the production of quinolinic acid from 3-hydroxyanthranilic acid in the rat hippocampus in vivo. Brain Res. Bull. 33: 513-516.
Salituro, F.G., R.C. Tomlinson, M.G. Palfreyman, W. Schmidt, H.-Q. Wu, P. Guidetti and Schwarcz (1994). Enzyme activated, strychnine insensitive glycine antagonists. J. Med. Chem. 37: 334-336.
McMaster, O., H. Baran, H.-Q. Wu, F. Du, E. French and R. Schwarcz (1993). Gamma acetylenic GABA produces axon-sparing neurodegeneration after focal injection into the rat hippocampus. Exp. Neurol. 124: 184-191.
Schwarcz, R., H.-Q. Wu, P.D. Shepard and R.C. Roberts (1993). Astrocytic kynurenines as modulators of dopaminergic function in the rat basal ganglia. in: Fuxe, K. ed, Trophic Regulation of the Basal Ganglia, pp 365-379, Pergamon Press, New York.
Wu, H.-Q., H. Baran, U. Ungestedt and R. Schwarcz (1992). Kynurenic acid in the quinolinate-lesioned rat hippocampus: studies in vitro and in vivo. Eur. J. Neurosci. 4: 1264-1270.
Wu, H.-Q., U. Ungestedt and R. Schwarcz (1992). Regulation of kynurenic acid synthesis studied in the dorsal hippocampus of unanesthetized rats. Eur. J. Pharmacol. 213:375-380.
Wu, H.-Q., W.A. Turski, U. Ungestedt and R. Schwarcz (1991). Systemic kainic acid administration in rats: effects on kynurenic acid production in vitro and in vivo. Exp. Neurol. 113:47-52.
Schwarcz, R., H. Baran, H.-Q. WU, F. Du and O. McMaster. The Neurochemistry of quinolinate and kynurenate: current concepts (1991). in F. Moroni et al eds. Excitatory Amino Acids; pp 367-375, Raven Press, New York.
Speciale, C., H.-Q. Wu, J.P. Gramsbergen, W.A. Turski, U. Ungestedt and R. Schwarcz (1990) Determination of extracellular kynurenic acid in striatum of unanesthetized rats: effects of aminooxyacetic acid. Neurosci. Lett. 116:119-203.
Wu, H.-Q., H.-X. Ping ,X.-N. Jing and G.-Q. Liu (1990) The effect of antiepilepsirine on the development of amygdala-kindling in rat. J. Chin. Pharm. Univ. 21(1): 59-61.
Ping, H.-X. and H.-Q. Wu (1990). Excitatory action on the unit activity of locus coeruleus induced by quinolinic acid in rats. Asia Pac. Pharmacol. 5(2):109-112.
Wu, H.-Q., H.-X. Ping, X.-M. Jia and G.-Q. Liu (1990). The Effect of antiepilepsirine on the amygdala kindling in rats. Chin. Pharmacol. Bullet. 6(2): 87-90.
Wu, H.-Q., X.-N. Jin, L. Xie and G.-Q. Liu (1990). An investigation of the release and metabolism of monoamine by striatal microdialysis. J. Chin. Pharmacol. Toxicol. 4: 9-13.