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George J Markelonis Ph.D.

Academic Title: Associate Professor (adjunct Faculty I I)
Primary Appointment: Anatomy and Neurobiology
gmarkelo@umaryland.edu
Location: HSF I, 280-E
Phone: (410) 706-3713
Fax: (410) 706-2512

Personal History:

  • University of Maryland, College Park, 1969, B.S., Zoology
  • Villanova University, 1972, M.S., Biology
  • University of Maryland, Baltimore, 1976, Ph.D., Pathology
  • Post-doctoral studies in Neurochemistry and Protein Isolation from 1976-1978 with Dr. T.H. Oh in Anatomy at the University of Maryland, Baltimore (UMB)
  • Muscular Dystrophy Association Post-doctoral Fellow, 1977-1978
  • Assistant Professor, Dept. of Anatomy, UMB, 1978-1984
  • Associate Professor, Dept. of Anatomy & Neurobiology, UMB, 1984-2007
  • Adjunct Associate Professor, Dept. of Anatomy & Neurobiology, UMB, 2007-Present

Research Interests:

Spinal cord regeneration; Factors affecting apoptosis after spinal cord traumatic injury; Isolation of protein factors promoting muscle regeneration; Roles of the protein, transferrin, in the nervous system; Models of cell culture used for screening drugs which promote neuronal growth and differentiation.


Publications:

Yune TY, Lee JY, Jung GY, Kim SJ, Jiang MH, Kim YC, Oh YJ, Markelonis GJ, Oh TH. Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury. J Neurosci. 2007 Jul 18;27(29):7751-61. PubMed PMID: 17634369.

Kim SJ, Yune TY, Han CT, Kim YC, Oh YJ, Markelonis GJ, Oh TH. Mitochondrial isocitrate dehydrogenase protects human neuroblastoma SH-SY5Y cells against oxidative stress. J Neurosci Res. 2007 Jan;85(1):139-52. PubMed PMID: 17075901.

Yune TY, Lee SM, Kim SJ, Park HK, Oh YJ, Kim YC, Markelonis GJ, Oh TH. Manganese superoxide dismutase induced by TNF-beta is regulated transcriptionally by NF-kappaB after spinal cord injury in rats. J Neurotrauma. 2004 Dec;21(12):1778-94. PubMed PMID: 15684769.

Lee SM, Yune TY, Kim SJ, Kim YC, Oh YJ, Markelonis GJ, Oh TH. Minocycline inhibits apoptotic cell death via attenuation of TNF-alpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures. J Neurochem. 2004 Nov;91(3):568-78. PubMed PMID: 15485488.

Yune TY, Kim SJ, Lee SM, Lee YK, Oh YJ, Kim YC, Markelonis GJ, Oh TH. Systemic administration of 17beta-estradiol reduces apoptotic cell death and improves functional recovery following traumatic spinal cord injury in rats. J Neurotrauma. 2004 Mar;21(3):293-306. PubMed PMID: 15115604.

Kim SR, Lee MK, Koo KA, Kim SH, Sung SH, Lee NG, Markelonis GJ, Oh TH, Yang JH, Kim YC.Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. J Neurosci Res. 2004 May 1;76(3):397-405. PubMed PMID: 15079869.

Lee SM, Yune TY, Kim SJ, Park DW, Lee YK, Kim YC, Oh YJ, Markelonis GJ, Oh TH. Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. J Neurotrauma. 2003 Oct;20(10):1017-27. PubMed PMID: 14588118.

Choi WS, Eom DS, Han BS, Kim WK, Han BH, Choi EJ, Oh TH, Markelonis GJ, Cho JW, Oh YJ. Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. J Biol Chem. 2004 May 7;279(19):20451-60. Epub 2004 Mar 1. PubMed PMID: 14993216.