Personal History:I received my PhD from University of Delhi, India. My PhD work was on the cholinesterase inhibitory and neuromuscular modulatory effects of beta-adrenergic blockers. I joined the research group of Dr. Albuquerque as a postdoctoral fellow and continued my research interests using electrophysiological techniques on muscle nicotinic receptors. As an assistant professor in the department of Pharmacology and Experimental Therapeutics I continue to work with Dr. Albuquerque on brain nicotinic receptor electrophysiology.
Lab Techniques and Equipment:
Alkondon, M., Rao, K.S. and Albuquerque, E.X. Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel. J. Pharmacol. Exp. Ther. 245: 543-556, 1988.
Alkondon, M., Costa, A.C.S., Radhakrishnan, V., Aronstam, R.S. and Albuquerque, E.X. Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead. FEBS Lett., 261: 124-130, 1990.
Alkondon, M., Pereira, E.F.R., Wonnacott, S. and Albuqueruqe, E.X. Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist. Mol. Pharmacol. 41: 802-808, 1992.
Alkondon, M. and Albuquerque, E.X. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther. 265: 1455-1473, 1993.
Alkondon, M., Pereira, E.F.R. and Albuquerque, E.X. Mapping the location of functional nicotinic and γ-aminobytyric acidA receptors on hippocampal neurons. J. Pharmacol. Exp. Ther. 279: 1491-1506, 1996.
Alkondon, M., Pereira, E.F.R., Cortes, W.S., Maelicke, A. and Albuquerque, E.X. Choline is a selective agonist of α7 nicotinic acetylcholine receptors in rat brain neurons. Eur. J. Neurosci. 9: 101-109, 1997.
Alkondon, M., Pereira, E.F.R., Eisenberg, H.M. and Albuquerque, E.X. Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. J. Neuroscience 19: 2693-2705, 1999.
Alkondon, M., Pereira, E.F.R., Eisenberg, H.M. and Albuquerque, E.X. Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks. J. Neuroscience 20: 66-75, 2000.
Alkondon, M, and Albuquerque, E.X. The nicotinic receptor α7 and α4β2 subtypes differentially control gabaergic input to CA1neurons in rat hippocampus. J. Neurophysiol. 86(6): 3043 -3055, 2001.
Alkondon, M and Albuquerque, EX. Nicotinic receptor subtypes in rat hippocampal slices are differentially sensitive to desensitization and early in vivo functional up-regulation by nicotine and to block by bupropion. J Pharmacol Exp Ther. 313(2):740-750, 2005
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