Our laboratory is focused on the study of bacterial pathogenesis. We use combined molecular biology, cell biology, biochemical, biophysical and structural biology approaches to gain insight into the processes by pathogens including E. coli and Clostridium difficile cause disease. The goal is to identify and characterize bacterial factors that are involved in interactions with host cells and to identify cellular mechanisms triggered by interactions with bacteria. We are also interested in novel approaches to prevent and treat bacterial infections. It is anticipated that these studies will impact not only our understanding and approach to infectious diseases, but also our appreciation for normal and abnormal cellular physiology.
Links of Interest:The Donnenberg Lab
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