I completed undergraduate work at the University of California, Berkeley in 1972, and obtained my Ph.D. from Harvard University in 1977. My thesis was on extracellular electrophysiology in the rat hippocampal slice and included some of the early studies on LTP. My postdoctoral training was with Roger Nicoll at UCSF. In 1981, I became an Assistant Professor in Department of Physiology at UMAB and in 1992 was promoted to Professor with tenure. In 2014, I was promoted to Professor Emeritus.
Mattison HA, Bagal AA, Mohammadi M, Pulimood NS, Reich CG, Alger BE, Kao JP, Thompson SM. (2014). Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons. J Neurophysiol. 2014 Apr 23. [Epub ahead of print] PMCID: PMC4064414
Nagode DA, Tang AH, Yang K, Alger BE. (2014) Optogenetic identification of an intrinsic cholinergically driven inhibitory oscillator sensitive to cannabinoids and opioids in hippocampal CA1. J Physiol. 2014 Jan 1;592(Pt 1):103-23. doi: 10.1113/jphysiol.2013.257428. Epub 2013 Nov 4. PMCID: PMC3903354
Alger BE. (2013) Getting high on the endocannabinoid system. Cerebrum 2013:14. eCollection. PMCID: PMC3997295
Dean SL, Wright CL, Hoffman JF, Wang M, Alger BE, McCarthy MM. (2012) Prostaglandin E2 stimulates estradiol synthesis in the cerebellum postnatally with associated effects on Purkinje neuron dendritic arbor and electrophysiological properties. Endocrinology. Nov;153(11):5415-27. PMCID: PMC3473195
Santos MD, Mohammadi MH, Yang S, Liang CW, Kao JP, Alger BE, Thompson SM, Tang CM. (2012) Dendritic hold and read: a gated mechanism for short term information storage and retrieval. PLoS One. 7(5):e37542. PMCID: PMC3358290
Kim J, Tsien RW, Alger BE. (2012) An improved test for detecting multiplicative homeostatic synaptic scaling. PLoS One. 7(5):e37364. PMCID: PMC3355135
Alger BE, Tang AH. (2012) Do cannabinoids reduce brain power? Nat Neurosci. Mar 27;15(4):499-501. PMCID: PMC3388600
Alger BE. (2012) Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know. J Physiol. May 1;590(Pt 10):2203-12. PMCID: PMC3424745
Wang M, Hill MH, Zhang L, Gorzalka B, Hillard CJ, Alger BE (2012) Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. J Psychopharmacol (Sep 2011, ePUB on-line) 26:56-71. PMCID: PMC3373303
Nagode, DA, Tang AH, Karson, MA, Klugmann, M, Alger BE (2011) Optogenetic release of ACh induces rhythmic bursts of perisomatic IPSCs in hippocampus. PLoS ONE 6:e27691. PMCID: PMC3218010
Alger BE, Kim J (2011) Supply and demand for endocannabinoids. Trends Neurosci 34:304-15. PMCID: PMC3106144
Tang AH, Karson MA, Nagode DA, McIntosh JM, Uebele VN, Renger JJ, Klugmann M, Milner TA, Alger BE (2011) Nerve terminal nAChRs initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca2+ channels and Ca2+ release from stores. J Neurosci 31:13546-13561. PMCID: PMC3353409
Waddell J, Kim J, Alger BE, McCarthy MM (2011) The Depolarizing Action of GABA in Cultured Hippocampal Neurons Is Not Due to the Absence of Ketone Bodies. PLoS ONE 6(8):e23020. PMCID: PMC3158756
Zhang L, Wang M, Bisogno T, Di Marzo V, Alger BE (2011) Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase. PLoS ONE Jan 28; 6(1):e16305. PMCID: PMC3030617
Zhang L and Alger BE (2010) Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci 30:5724-5729. PMCID: PMC2906112
Kim J and Alger BE (2010) Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nature Neurosci 13:592-600. PMCID: PMC2860695
Karson MA, Tang AH, Milner TA, Alger BE (2009) Synaptic cross talk between perisomatic-targeting interneuron classes expressing cholecystokinin and parvalbumin in hippocampus. J Neurosci 29:4140-54. PMCID: PMC2853357
Lafourcade CA, Alger BE (2008) Distinctions among GABAA and GABAB responses revealed by calcium channel antagonists, cannabinoids, opioids and synaptic plasticity in rat hippocampus. Psychopharmacol, (Dec 2007; ePUB on-line) 198:539-549. PMCID: PMC2906116
Edwards DA, Zhang L, Alger BE (2008) Metaplastic control of hippocampal endocannabinoid responses. Proc Natl Acad Sci (USA), 105:8142-8147. PMCID: PMC2409138
Reich CG, Mohammadi M, Alger BE (2008) Endocannabinoid modulation of responses in multiple-trial trace and delay fear conditioning. J Psychopharmacol (Feb 2008; ePUB on-line) 22:769-77. PMCID: PMC2906780
Karson MA, Whittington KC, Alger BE (2008) Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others. Neuropharmacol (July 2007; ePUB on-line) 54:117-128. PMCID: PMC2242378
Edwards, D.A., Kim, J. and Alger, B.E. (2006) Multiple mechanisms of endocannabinoid response initiation in hippocampus. J. Neurophysiol. (ePUB online October 5, 2005) 95: 67-75.
Isokawa, M. and Alger, B.E. (2006) The ryanodine receptor regulates endogenous cannabinoid mobilization in the hippocampus. J. Neurophysiol. (ePUB online February 5, 2006) 95: 3001-3011.
Reich, C.G., Karson, M.A., Karnup, S.V., Jones, L.M. and Alger, B.E. (2005) Regulation of IPSP theta rhythm by muscarinic receptors and endocannabinoids in hippocampus. J. Neurophysiol. 94: 4290-4299.
Isokawa, M. and Alger, B.E. (2005) Retrograde endocannabinoid regulation of GABAergic inhibition in the rat dentate gyrus granule cell. J. Physiol. 567: 1001-1010.
Heinbockel, T., Brager, D.H., Reich, C.G., Zhao, J., Muralidharan, S., Alger, B.E. and Kao, J.P. (2005) Endocannabinoid signaling dynamics probed with optical tools. J. Neurosci. 25(41): 9449-9459.
Kim, J., and Alger, B.E. (2004) Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid signaling in hippocampus. Nature Neurosci. 7: 697-699.
Brager, D.H., Luther, P.W., Edrélyi, F., Szabó, G. and Alger, B.E. (2003) Regulation of exocytosis from single visualized GABAergic boutons in hippocampal slices. J. Neurosci. 23(33): 10475-10486.
Reich, C.G., Mason, S.E. and Alger, B.E. (2003) A novel form of LTD induced by transient, partial inhibition of the Na,K-pump in rat hippocampal CA1 cells. J. Neurophysiol. 91: 239-247.
Vaillend, C., Mason, S.E., Cuttle, M.F. and Alger, B.E. (2002) Mechanisms of neuronal hyperexcitability caused by partial inhibition of Na+, K+ -ATPases in the rat CA1 hippocampal region. J. Neurophysiol. 88: 2963-2978
Alger, B.E. (2002) Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids. Progress in Neurobiology. 68: 247–286
Kim, J., Isokawa, M., Ledent, C. and Alger, B.E. (2002) Activation of muscarinic acetylcholine receptors enhances the release of endocannabinoids in the hippocampus. J. Neurosci. 22: 10182-91
Varma, N., Brager, D.H., Morishita, W., Lenz, R.A., London, B. and Alger, B.E. (2002) Presynaptic factors in the regulation of DSI expression in hippocampus. Neuropharmacology. 43: 550-562.
Carlson, G., Wang, Y. and Alger, B.E. (2002) Endocannabinoids facilitate the induction of LTP in the hippocampus. Nature Neurosci. 5: 723-724.