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Laure  Aurelian
 

Laure Aurelian Ph.D.

Academic Title: Professor
Primary Appointment: Pharmacology
Secondary Appointments: Microbiology and Immunology
laurelia@umaryland.edu
Location: MSTF 500F
Phone: (410) 706-3895

Research Interests:

Our laboratory studies signaling pathways involved in cell proliferation and apoptosis and has pioneered the application of antisense chemotherapy to the control of virus infections. Current studies focus on the use of a HSV-2 gene with serine-threonine protein kinase function (ICP10 PK) that activates the ERK signaling pathway in gene therapy of neurological disorders that involve apoptosis. We cloned a cellular gene (H11) homologous to ICP10 PK that codes for a heat shock protein and showed that its overexpression causes apoptosis in melanoma cells. Ongoing studies are focused on understanding the molecular mechanism of H11 induced apoptosis, its regulation and its role in melanoma development. Additional interests are in the molecular and immunological aspects of HSV-associated erythema multiforme, a recurrent cutaneous disease that follows HSV recurrences. Our laboratory developed an immunotherapeutic vaccine that prevents HSV recurrences and is currently in clinical trials.

Lab Techniques and Equipment:

We utilize a wide spectrum of molecular and cellular biology, virology and immunology techniques, including gene cloning, site-directed, deletion and insertion mutagenesis, gene expression, gene arrays, differential gene expression, yeast-two hybrid assays, promoter studies, cell proliferation and apoptosis assays, development of virus vectors and vaccines and T cell assays.

Recent Trainees:

Recent Ph.D. Students
Samantha Wells
Michael Gober
Dana Perkins
John Nelson
Tao Peng

Recent Postdoctoral Trainees
Fumitake Ono
Kaori Ueda
Rui He
Yanxing Yu
Takahiro Gyotoku
Hisashi Kokuba
Shinichiri Imafuku
Jia Zhu


Training History:

* M. Sc., Tel-Aviv University, Israel
* PhD., Johns Hopkins University, USA

Publications:

Li B, Smith CC, Laing JM, Gober MD, Liu L, Aurelian L. Overload of the heat-shock protein H11/HspB8 triggers melanoma cell apoptosis through activation of transforming growth factor-beta-activated kinase 1.Oncogene. 2006 Dec 18; [Epub ahead of print] PMID: 17173073 [PubMed - as supplied by publisher]
 
Golembewski EK, Wales SQ, Aurelian L, Yarowsky PJ. The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity. Exp Neurol. 2007 Feb;203(2):381-93. Epub 2006 Oct 16. PMID: 17046754 [PubMed - in process]
 
Sharma BK, Smith CC, Laing JM, Rucker DA, Burnett JW, Aurelian L. Aberrant DNA methylation silences the novel heat shock protein H11 in melanoma but not benign melanocytic lesions. Dermatology. 2006;213(3):192-9. PMID: 17033167 [PubMed - indexed for MEDLINE]
 
Gober MD, Laing JM, Thompson SM, Aurelian L. The growth compromised HSV-2 mutant DeltaRR prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures. Brain Res. 2006 Nov 13;1119(1):26-39. Epub 2006 Oct 3. PMID: 17020750 [PubMed - indexed for MEDLINE]
 
Laing JM, Gober MD, Golembewski EK, Thompson SM, Gyure KA, Yarowsky PJ, Aurelian L. Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice. Mol Ther. 2006 May;13(5):870-81. Epub 2006 Feb 24. PMID: 16500153 [PubMed - indexed for MEDLINE]
 
Wales, S., Smith C.C. and Aurelian, L. The herpes simplex virus type 2 (HSV-2) gene ICP10PK has a wide neuroprotective spectrum through activation of survival signaling pathways. Revista Brasileira de Neurologia pp 113-126, 2006.
Wales, S.Q. and Aurelian, L. Neuroprotection by the herpes simplex virus type 2 protein ICP10PK Following loss of trophic growth support – signaling molecules and survival pathways.  J. Neurochem. Submitted.