Alan R. Shuldiner, M.D.
Professor of Medicine
Head, Division of Endocrinology, Diabetes & Nutrition

M.D.: Harvard Medical School

Clinical and Research Interests: Alan R. Shuldiner, M.D. studies the genetics of complex disorders including type 2 diabetes, insulin resistance and obesity. Identification of susceptibility genes for these disorders will provide novel avenues for therapy and prevention. Utilizing candidate gene and positional cloning approaches, he searches for susceptibility genes for diabetes and obesity, as well as gene variants that may predict responsivity to medications used to treat diabetes (pharmacogenomics). These studies have led to the identification of genetic variants in the beta-3-adrenergic receptor and peroxisome proliferator activated receptor-gamma (PPAR-gamma), which are susceptibility genes for obesity and/or type 2 diabetes. Collaborations with investigators throughout the world provide access to thousands of DNA samples from diverse populations for these studies including Pima Indians, Mexican Americans and African Americans. In addition, in his Amish Research Clinic in Strasburg, PA, Dr. Shuldiner has recruited and studied over 2,500 Old Order Amish subjects for a genome-wide scan and positional cloning of susceptibility genes for complex diseases including type 2 diabetes, obesity, osteoporosis, hypertension and longevity, as well as to dissect gene-environment interactions in shaping the risk of cardiovascular disease.

Academic Office:  410-706-1623
Fax:  410-706-1622
E-mail:  shuldin@medicine.umaryland.edu

Address:
University of Maryland, School of Medicine
Department of Medicine
Division of Endocrinology, Diabetes and Nutrtion
660 W. Redwood Street, HH - Room 494
Baltimore, Maryland  21201

Key Papers

  1. Hsueh W.-C., Mitchell B.D., Schneider J.L., St. Jean P.L., Pollin T.I., Ehm M.G., Wagner M.J., Burns D.K., Sakul H., Bell C.J., Shuldiner A.R. Genome-wide scan of obesity in the Old Order Amish (2001) J. Clin. Endocrinol. Metab. 86, 1199-1205.

  2. Mitchell B.D., Hsueh W.-C., King T.M., Pollin T.I., Sorkin J., Agarwala R., Schaffer A.A., Shuldiner A.R. Familial contributions to life span in the Old Order Amish (2001) Am. J. Med. Genet. 102, 346-352.

  3. Nicklas B.J., van Rossum E.F.C., Berman D.M., Ryan A.S., Dennis K.E., Shuldiner A.R. Genetic variation in the peroxisome proliferator-activated receptor-g2 gene (Pro12Ala) affects metabolic responses to weight loss and subsequent weight gain (2001) Diabetes 50, 2172-2176.

  4. Mentuccia D., Proietti-:annunzi L., Tanner K., Bacci V., Pollin T.I., Poehlman E.T., Shuldiner A.R., Celi F.S. Association between a novel variant of the human type 2 deiodinase (DIO2) gene, Thr92Ala and insulin resistance: Evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor (ADRB3) (2002) Diabetes 51, 880-883.

  5. Garant M.J., Kao W.H.L., Brancati F., Coresh J., Rami T.M., Hanis C.L., Boerwinkle E., Shuldiner A.R. SNP43 of the calcium-activated neutral protease (CAPN10) and the risk of type 2 diabetes in African-Americans: The atherosclerosis risk in communities (ARIC) study (2002) Diabetes 51, 231-237.

  6. Steinle N., Hsueh W.-C., Snitker S., Mitchell B.D., Pollin T.I., Sakul H., St. Jean P.S., Bell C.J., Shuldiner A.R. Genetics of eating behavior in the Amish: Evidence for linkage to regions of chromosomes 3, 6, 7 and 17 (2002) Am. J. Clin. Nutr. 75, 1098-1106.
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