Insults to the vasculature can cause a wide range of life threatening diseases that include: stroke, myocardial infarction, hypertension, diabetes and chronic kidney disease. Inflammation is emerging as a key contributor to many vascular diseases and further, plays a major role in autoimmune diseases, arthritis, allergic reactions and cancer. Tumor cells can induce the formation of new blood vessels through a process called angiogenesis and in concert with inflammation is thought to be critical in the transition from a benign to a malignant disease.
Research at the Center focuses on integrating molecular and cell biology with applied and clinical sciences specifically in the areas of biochemistry, vascular biology, immunology, cancer biology, hematopoiesis, stem cell biology and cardiology.
| CVID Fall 2009 Seminar Series Noon in room 309 of BioPark One Seminars in November & December |
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| November 4 - Charles L. Chaffin, Ph.D., Associate Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland, "Lipoprotein uptake as a mediator of the ovulatory cascade in primates"
Host: Toni M. Antalis, Ph.D. |
| November 11 - Silvia Montaner, Ph.D., M.P.H., Associate Professor, Department of Oncology and Diagnostic Sciences and Pathology and Greenebaum Cancer Center, University of Maryland, "KSHV vGPCR: Lessons on inflammation-mediated angiogenesis from a viral oncogene"
Host: Toni M. Antalis, Ph.D. |
| November 18 - No Seminar
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| December 2 - Kathleen P. Pratt, Ph.D., Assistant Member, Puget Sound Blood Center, Seattle, WA, "Mapping T-Cell and B-Cell Epitopes to Design Less Immunogenic Factor VIII Proteins"
Host: David Scott, Ph.D. |
| December 9 - Tami J Kingsbury, Ph.D., Assistant Professor, Department of Physiology, University of Maryland, "Cellular regulation of calcineurin phosphatase activity"
Host: Nancy Fossett, Ph.D. |
| December 16 - Joseph Craft, M.D., Professor of Medicine, Chief of Rheumatology, Professor of Immunobiology and Director of Investigative Medicine, Yale University School of Medicine, "New Insights into Effector CD4 T Cell Differentiation and Function"
Host: David Scott, Ph.D. |
| Cutting Edge Research at the CVID | |
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Nicola M. Heller Ph.D., Xiulan Qi and Achsah D. Keegan Ph.D. of the CVID published an article in the journal Science Signaling. "Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages" Nicola M. Heller, Xiulan Qi, Ilkka S. Junttila, Kari Ann Shirey, Stefanie N. Vogel, William E. Paul, and Achsah D. Keegan (23 December 2008)
The ability of IL-4, but not IL-13, to efficiently activate IRS-2 leads to the expression of a subset of genes in alternatively activated macrophages. |
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