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CTSI: Global Health

Bidirectional Community Engagement from West Baltimore to West Africa

The Global Resource is an innovative component of the CTSI bridging the CERR and the PCIR, expanding further the concept of “PCIR without walls” to “PCIR without borders”. It builds upon a 38 year track record of international clinical and translational research and community engagement developed by Dr. Myron Levine, the Founding Director of the Center for Vaccine Development (CVD), an internationally acclaimed research center responsible for major advances in vaccine and therapy research targeting major health threats worldwide. The CVD paradigm follows a systematic process that identifies problems through epidemiologic field studies, addresses them with laboratory bench research, introduces them in clinical trials, integrates new basic science insights gained from results of clinical trials and returns to the field for larger scale clinical trials with improved products. The strategy is also guided by the West Baltimore – West Africa Research Framework that provides investigators access to populations with shared risk for diseases of disparity among underserved minority populations that account for major morbidity and mortality among the African American population of Baltimore and among citizens of West Africa (Nigeria and Mali) who share a common genetic pool.  Diseases such as diabetes, hypertension, prostate, cervical and breast cancer are important targets whose pathogenesis research is enriched by this Global Resource interface. The CTSI Global Resource is innovative in that this is a public health focused agenda by virtue of a basic science emphasis targeting translation of research discovery, and is heavily reliant on creative approaches to community engagement.
 
The objective of the CTSI Global Health Resource is to harness our established strong international health and community engagement programs as a platform for translation of basic discovery to populations impacted by diseases of local and global impact. We will implement clinical trials of innovative interventions developed and piloted in Baltimore in international populations experiencing high burden of diseases of interest, and conduct translational research among populations in West Africa genetically related to underserved minorities in Baltimore to gain fundamental insights at the genomic, cellular, individual, and population level to address diseases of disparity, the so called West Baltimore – West Africa Initiative.

Leadership

William Blatner
 

William Blattner M.D.Professor of Medicine and Epidemiology & Public Health
Co-Founder; Institute of Human Virology
wblattner@ihv.umaryland.edu
Location: Institute of Human Virology, Room N449
Phone: (410) 706-1941

 
Christopher Plowe
 

Christopher Plowe M.D., M.P.H.Professor OF Medicine and Epidemiology & Public Health, Microbiology and Immunology
Leader, Malaria Group; Associate Director for Research Training, Center for Vaccine Development; Investigator, Howard Hughes Medical Institute
cplowe@medicine.umaryland.edu
Phone: (410) 706-2491

 
Robert Redfield
 

Robert Redfield M.D.Professor of Medicine and Microbiology and Immunology
Medical Director of the Institute of Human Virology
Chief of Infectious Diseases and Director of the HIV program, UMMC
rredfield@ihv.umaryland.edu
Phone: (410) 706-4613

 
Meriam Laufer
 

Miriam K Laufer M.D.Associate Professor of Pediatrics and Eidemiology & Public Health and Medicine
mlaufer@medicine.umaryland.edu
Location: HSF1, Room 480
Phone: (410) 706-8695

Key Faculty

Other key faculty include Myron M. Levine MD, DTPH the father of global translational research at UM, and a member of the Institute of Medicine of the National Academy of Sciences.  Clement A Adebamowo D.Sc., MD, FWACS, FACS, Associate Professor UMSOM, directs research in the IHV Nigeria with expertise in human genomics among African populations and in studies of diseases that disproportionately impact underserved minorities. Samer El-Kamary, MBChB, MS, MPH, Assistant Professor UMSOM, Director of the UM Egypt Center, undertakes fundamental studies of acute and chronic hepatitis in Egypt.  Joseph F O'Neill M.D., M.P.H., Director of the UM Global Program provides linkages to all schools at UMB and UMCP