Research

Research Projects

• Protective immune mechanisms to S. dysenteriae 1 vaccines in macaques and humans
• Local and systemic specific immunity, microbiome and H. pylori infection in children, adults and the elderly
• Effect of oral immunization with the Ty21a typhoid vaccine on local and systemic immune responses and the gut microbiota in children, adults and the elderly
• Intestinal mucosal immune and functional response to gastric and enteric pathogens

Technology Developmental Projects

• A novel ORFeome approach to identify CD8+ T cell responses to S. Typhi proteins in humans
• Peptide conformation constrainment technology and novel mucosal adjuvants to advance H. pylori vaccine development

Pilot Projects

The CCHI Pilot Projects Core is designed to incorporate new projects, new investigators and new institutions into the existing CCHI program. Pilot projects will focus on human mucosal immunology and Category A, B, or C Priority Pathogens, their toxins, or other emerging or re-emerging infectious diseases on the NIAID list. Specifically, applicants must propose work in the area of mucosal immunity relating to the gastrointestinal tract in order to synergize with the goals of the UMB-CCHI. Any current solicitations for proposals can be found on the Opportunites page. 

• Development of advanced proteomic methods to monitor baseline and postimmunization mucosal immunological profiles of the human gastrointestinal tract via stool samples  
• Vascularized organotype model of the human intestinal mucosa  
• The role of sIgA B memory cells in mucosal mechanisms of protection in Shigella challenge studies