Publications - Schizophrenia
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A novel, primate-sepecific brain isoform of KCNH2 impacts cortical physiology, cognition, neuronal repolarization, and risk for schizophrenia. Huffaker, S.J., Chen, J., Nicodemus, K.K., Sambataro, F., Yang, F., Mattay, V., Lipska, B.K., Hyde, T.M., Song, J., Rujescu, D., Giegling, I., Mayilyan, K., Soghoyan, A., Caforio, G., Bertolino, A., Chang, J., Egan, M. and Kleinman, J.E. Nature Medicine 15: 509-518, 2009. [paper]
Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correleation with polymorpshism SERTLPR. Lim, J., Pinsonneault, J., Sadee, W. and Saffen, D. Molecular Psychiatry 1-14, 2006. [paper]
Cingulate white matter neurons in bipolar disorder and schizophrenia. Connor, C.M., Guo, Y., and Akbarian, S. Biological Psychiatry 66(5): 486-493, 2009 [paper]
Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expresssion in human brain. Kao, W.-T., Wang, Y., Kleinman, J.E., Lipska, B.K., Hyde, T.M., Weinberger, D.R. and Law, A.J. www.pnas.org/cgi/doi/10.1073/pnas.1005410107 [paper]
DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. Nakata, K., Lipska, B.K., Hyde, T.M., Ye, T., Newburn, E.N., Morita, Y., Vakkalank, R., Bernboim, M., Sei, Y., Weinberger, D.R. and Kleinman, J.E. Proc. Natl. Acad. Sci. USA 106: 15873-15878, 2009. [paper]
Developmental regulation of NCAM in human frontal cortex. Jarskog, L., Maness, P., Gable, K., LaMantia, A., Lieberman, J. and Gilmore, J. Amer. College of Neuropshchopharmacolog, 2005. [abstract]
Developmental regulation of NRG1 and erbB4 expression in human prefronal cortex. Gilmore, J., Glantz, L., Vadlamudi, S. and Jarskog, L. Biological Psychiatry Meeting, 2005. [abstract]
Developmental regulation of PSA-NCAM in human frontal cortex. Cox, E., Maness, P., Gilmore, J. and Jarskog, L. Bio. Psychiatry Meeting, 2006. [abstract]
Developmental regulation of the NMDA receptorsSubunits, NR3A and NR1, in human prefrontal cortex. Henson, M., Roberts, A., Salimi, K., Vadlamudi, S., Hamer, R. Gilmore, J., Jarskog, L. and Philpot, B.` Cerebral Cortex 18:2560-2573, 2008. [paper]
Epigenetic determinants of GAD1/GAD67 (2q31.1) expression in human prefrontal cortex. Huang, H. and Akbarian, S. Neuropsychopharmacology 30: S112, 2005, Suppl. 1. [abstract]
Expression of the cannabinoid receptor CNR1 in schizophrenia and across life span in postmortem human cortex. Kleinman, J., Joseph, A., Joseph, L., Hyde, T., Mitkus, S., Ye, T., Herman, M., Kolachana, B. and Lipska, B. SFN, 2007: 706-13/Y11. [abstract]
Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia. Harris, L.W., Lockstone, H.E., Khaitovich, P., Weickert, C.S., Webster, M.J., Bahn, S. BMC Medical Genomics 2:28, 2009. [paper]
Genectic variants modulating dopamine D2 expression in human brain are associated with schizophrenia. Zhang, Y., Papp, A. and Sadee, W. Presented 2006. [abstract]
Genetic and epigenetic modulation of dopamine D2 and nicotinic alpha 4 subunit activity in human brain. Zhang, Y., Papp, A. and Sadee, W. Presented 2006. [abstract]
Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain. Stadler, F., Kolb, G., Rubusch, L., Baker, S., Jones, E. and Akbarian, S. J. Neurochem. 94: 324-336, 2005. [paper]
Molecular neurocytogenetics demonstrates oncogenic parallels in schizophrenia: implications for neuroprotection and neuroregeneration. Iourov, I., Vorsanova, S. and Yorov, Y. IJNN 2:212-214, 2006. [paper]
Prefrontal Dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters Huang, H., Matevossian, A., Whttle, C., Kim, S., Schumacher, A., Baker, S. and Akbarian, S. J. Neurosci. 24:11254-11262, 2007. [paper]
Synaptophysin in the human prefrontal cortex from birth through adulthood. Glantz, L., Gilmore, J., Lieberman, J. and Jarskog, L. Biological Psychiatry, 2005. [abstract]
The effect of genetic polymorphisms on the expression of serotonin transporter (SERT) mRNA in the raphe nuclei of human pons. Lim, J., Saffen, D. and Sadee, W. Presented 2006. [abstract]
Typtophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Lim, J., Pinsonneault, J., Sadee, W. and Saffen, D. Molecular Psychiatry 1-11, 2006. [paper]
Ultrastructural localization of reelin in the cortex in post-mortem human brain. Roberts, R., Xu, L., Roches, J. and Kirkpatrick, B. J. Comparative Neurology 482: 294-308, 2005. [paper]